223117

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-higA/HigB-HigA
Location 3053501..3054340 Replicon chromosome
Accession NZ_CP086369
Organism Pectobacterium versatile strain A73-S18-O15

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag LLE50_RS13835 Protein ID WP_130621309.1
Coordinates 3053978..3054340 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag LLE50_RS13830 Protein ID WP_039470394.1
Coordinates 3053501..3053974 (-) Length 158 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LLE50_RS13810 (LLE50_13805) 3048606..3049529 - 924 WP_103942115.1 aminoimidazole riboside kinase -
LLE50_RS13815 (LLE50_13810) 3049853..3050041 + 189 WP_039482134.1 hypothetical protein -
LLE50_RS13820 (LLE50_13815) 3050211..3050762 + 552 WP_130621311.1 polymer-forming cytoskeletal protein -
LLE50_RS13825 (LLE50_13820) 3050794..3053511 + 2718 WP_130621310.1 CRISPR-associated helicase Cas3' -
LLE50_RS13830 (LLE50_13825) 3053501..3053974 - 474 WP_039470394.1 helix-turn-helix domain-containing protein Antitoxin
LLE50_RS13835 (LLE50_13830) 3053978..3054340 - 363 WP_130621309.1 type II toxin-antitoxin system HigB family toxin Toxin
LLE50_RS13840 (LLE50_13835) 3054954..3056522 + 1569 WP_130621308.1 type I-E CRISPR-associated protein Cse1/CasA -
LLE50_RS13845 (LLE50_13840) 3056506..3057153 + 648 WP_107332210.1 type I-E CRISPR-associated protein Cse2/CasB -
LLE50_RS13850 (LLE50_13845) 3057157..3058221 + 1065 WP_130621307.1 type I-E CRISPR-associated protein Cas7/Cse4/CasC -
LLE50_RS13855 (LLE50_13850) 3058231..3058965 + 735 WP_103971370.1 type I-E CRISPR-associated protein Cas5/CasD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(73-111)

Antitoxin

Antitoxin HigA

(43-157)


Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 14147.36 Da        Isoelectric Point: 9.7305

>T223117 WP_130621309.1 NZ_CP086369:c3054340-3053978 [Pectobacterium versatile]
MRVISAKAITDAMKKHAKWKVGLKLWLDVFDKPSLRFESYEQLCHVWRNTSCWNVDRIPFGLLENESRKGPLDIYVFDIN
GNNCRIIAWLNPNTGSLYVKDVCSHAEYDKWWKAQTKTKR

Download         Length: 363 bp

>T223117 NZ_CP118532:c1731152-1730862 [Vibrio harveyi]
ATGACCTATAAACTCGACTTTAAAAAGAGCGCCCTCAAAGAGTGGAAAAAGCTTGGTTCTACTCTGCAACAACAATTTAA
GAAAAAGCTAATCGAGCGCTTAGATAACCCACATGTTCCGGCTTCAAAATTGTCTGGAGCTGACAACATGTATAAAATTA
AGTTGCGTCAATCGGGCTACCGTCTCGTCTACAAAGTTGAAGACGATGTGATCATTGTAACCGTCCTAGCAGTTGGAAAG
CGCGAACGTAGCGATGTTTACCGTAAAGCCATGAAAAGGTTAGATGACTGA

Antitoxin


Download         Length: 158 a.a.        Molecular weight: 17763.02 Da        Isoelectric Point: 4.2043

>AT223117 WP_039470394.1 NZ_CP086369:c3053974-3053501 [Pectobacterium versatile]
MRNTSLGSNSSVGISGLIENLPLLLQEASEQLNSLSVLLSACMEPIEDDNDLQERMECINQLYLYSSDVNDIPATFAELI
ADRVYEYEKKHRDVPHVSQAEALAFFIEERGLKQSDLKQIATQSVISDIINGKRTMTLQQVKDFSRYFNVPVETFID

Download         Length: 474 bp

>AT223117 NZ_CP118532:c1731390-1731142 [Vibrio harveyi]
ATGACCACTAGAATTTTAGCCGATGTTGCTGCAAGCATTACTGAGTTGAAAGCTAACCCTATGAAAGTTGCAACTAGTGC
TTACGGCGAACCTGTAGCTGTATTAAACCGAAATGAACCAGCATTTTATTGCGTACCTGCCGAAGCGTACGAAATGATGA
TGGACAGACTCGAAGATCTTGAACTACTCGCTATCGCTAAAGAGCGTGAATCTGAAGAGAGCATTTCGGTAAATATTGAT
GACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References