223116

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-DnaT
Location 3007063..3007594 Replicon chromosome
Accession NZ_CP086369
Organism Pectobacterium versatile strain A73-S18-O15

Toxin (Protein)


Gene name stbE Uniprot ID A0A249QBN7
Locus tag LLE50_RS13630 Protein ID WP_039493031.1
Coordinates 3007307..3007594 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID A0A3R8PFZ6
Locus tag LLE50_RS13625 Protein ID WP_039470361.1
Coordinates 3007063..3007317 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LLE50_RS13605 (LLE50_13600) 3002207..3004225 - 2019 WP_130621508.1 penicillin-binding protein activator -
LLE50_RS13610 (LLE50_13605) 3004287..3005174 + 888 WP_116586249.1 16S rRNA (cytidine(1402)-2'-O)-methyltransferase -
LLE50_RS13620 (LLE50_13615) 3005626..3006818 - 1193 Protein_2651 IS4 family transposase -
LLE50_RS13625 (LLE50_13620) 3007063..3007317 + 255 WP_039470361.1 plasmid stabilization protein Antitoxin
LLE50_RS13630 (LLE50_13625) 3007307..3007594 + 288 WP_039493031.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LLE50_RS13635 (LLE50_13630) 3007770..3008555 + 786 WP_103861632.1 4,5-DOPA dioxygenase extradiol -
LLE50_RS13640 (LLE50_13635) 3008742..3009902 - 1161 WP_010297418.1 glutathionylspermidine synthase family protein -
LLE50_RS13645 (LLE50_13640) 3009913..3010587 - 675 WP_103861630.1 DUF1190 family protein -
LLE50_RS13650 (LLE50_13645) 3010853..3012247 - 1395 WP_103861629.1 outer membrane channel protein TolC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 3005626..3005982 356


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10993.93 Da        Isoelectric Point: 10.7694

>T223116 WP_039493031.1 NZ_CP086369:3007307-3007594 [Pectobacterium versatile]
MTYKLKFVPSALKEWKKLGHPVREQFKKKLVERLENPRVPSAQLHGRKDQYKIKLKSAGYRLVYLVQDETITVMVMGVGK
REGSQIYSDTKGRSA

Download         Length: 288 bp

>T223116 NZ_CP118532:c1720669-1720391 [Vibrio harveyi]
ATGATTTTATGGGAAGAAGAGTCACTTAATGATCGTGAAAAGATCTTCGAGTTTCTCTATGACTTTAACCCTGATGCGGC
AGAAAAAACTGACAACCTCATTGAAGCAAAAGTAGAAAACTTGCTTGAACAACCTTTAATGGGTGTACAACGCGATGGCA
TCCGCGGACGATTGCTCATTATTCCTGAGATTTCGATGATTGTGTCTTACTGGCTCGAGGGCGATATCATCCGAGTTATG
CGTGTACTCCACCAGAAACAAAAATTCCCTACAGATTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9192.34 Da        Isoelectric Point: 3.7947

>AT223116 WP_039470361.1 NZ_CP086369:3007063-3007317 [Pectobacterium versatile]
MAFNILTNTAASITELKRDPMGTVRAAEGETIAILNRNEPAFYCVPPAVFAYLMELAEDAELGRTVDDRMSELADAEEIS
PDDL

Download         Length: 255 bp

>AT223116 NZ_CP118532:c1720950-1720666 [Vibrio harveyi]
ATGGACACTAGAATTCAATTTCGTGTTGATGAAGAAACAAAACGCCTAGCTCAACAAATGGCTGAGAGCCAAGGTCGAAC
TTTAAGTGATGCTTGCCGTGAACTTACTGAGCAACTCGCTGAACAACAAAGAAAAACATTATCTCACGATGCATGGCTAA
CTGAACAAGTAAACCTAGCATTTGAGAAGTTTGACTCAGGAAAATCCGTTTTCGTTGAGCACCAAACTGCTAAATCTCGA
ATGGAAGAGCGCAAAGCCAGAATCCGTAATCGAGGTAAGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A249QBN7

Antitoxin

Source ID Structure
AlphaFold DB A0A3R8PFZ6

References