Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2568483..2570068 Replicon chromosome
Accession NZ_CP086369
Organism Pectobacterium versatile strain A73-S18-O15

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag LLE50_RS11615 Protein ID WP_130621335.1
Coordinates 2568749..2570068 (+) Length 440 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag LLE50_RS11610 Protein ID WP_010302402.1
Coordinates 2568483..2568749 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LLE50_RS11580 (LLE50_11575) 2563554..2564105 + 552 WP_107333668.1 TetR/AcrR family transcriptional regulator -
LLE50_RS11585 (LLE50_11580) 2564155..2564565 - 411 WP_103862408.1 helix-turn-helix domain-containing protein -
LLE50_RS11590 (LLE50_11585) 2564680..2565531 + 852 WP_130621337.1 SDR family oxidoreductase -
LLE50_RS11595 (LLE50_11590) 2565681..2566505 - 825 WP_130621336.1 HNH endonuclease signature motif containing protein -
LLE50_RS11600 (LLE50_11595) 2566602..2567627 + 1026 WP_127032198.1 IS630 family transposase -
LLE50_RS11605 (LLE50_11600) 2567756..2568322 - 567 WP_103862406.1 hypothetical protein -
LLE50_RS11610 (LLE50_11605) 2568483..2568749 + 267 WP_010302402.1 helix-turn-helix domain-containing protein Antitoxin
LLE50_RS11615 (LLE50_11610) 2568749..2570068 + 1320 WP_130621335.1 type II toxin-antitoxin system HipA family toxin Toxin
LLE50_RS11620 (LLE50_11615) 2570225..2571589 - 1365 WP_130621334.1 tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE -
LLE50_RS11625 (LLE50_11620) 2571719..2573353 - 1635 WP_039485128.1 membrane protein insertase YidC -
LLE50_RS11630 (LLE50_11625) 2573356..2573613 - 258 WP_010302384.1 membrane protein insertion efficiency factor YidD -
LLE50_RS11635 (LLE50_11630) 2573577..2573936 - 360 WP_010302382.1 ribonuclease P protein component -
LLE50_RS11640 (LLE50_11635) 2573955..2574095 - 141 WP_005976668.1 50S ribosomal protein L34 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2566602..2567627 1025


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 440 a.a.        Molecular weight: 49283.40 Da        Isoelectric Point: 6.5030

>T223114 WP_130621335.1 NZ_CP086369:2568749-2570068 [Pectobacterium versatile]
MAALDVYMNGYRVGILTKTGSGAHHFSYDANWLGLPGSRPISLSMPLRHQSYQGDEVYNFFDNLLPDNPDIRRRIVARHH
ADSTQPFDLLDKVGKDSVGALQIVPQGTPVHDIKKIEYKTLSEQQLENILTGYLSDAPLGMIDTEDDFRISIAGAQEKTA
LLYLDDHWCLPFSTTPTTHIIKLPIGKIESHSYSIDMSDSVENEYLCLLIAKAFGLPVPHCFMINAGKIKALAVERFDRK
YASDVSWIMRLPQEDFCQVLNVPSALKYENHGGPGISAIMSFLLGSVDPERDRYRFMQAQVLFWLLAATDGHAKNFSLFI
ESEGRYRLTPFYDILSMYPAMGGRGIDRREAKLAMGLTGSRGKKYAIEQIFPRHFFQTAKAVGFARESMENILVEFSNTV
ETVMTTVGSQLPVDFPTHISEAILAGLQARSRRLMSGWE

Download         Length: 1320 bp

>T223114 NZ_CP118530:1408082-1408384 [Vibrio harveyi]
ATGGCTGAAATAATCTGGACTGAGCCAGCGTTATCTGACCTCAACGATATCGCTGAATACATCGCACTTGAAAATATCGT
AGCTGCAAAGCAGTTAGTGCAAACGATCTTCTCCAAAGTCGAACGTTTACAAACTTTCCCAGAGTCAGGTCGTATTCCAC
CCGATCTAAAACATTTAAGTTATCGTGAAGTTGTCGTTAATCCATGTCGTGTTTTCTATAAACAAGACGGTGACAAAGTG
TTTATTTTGTTTGTTATGCGCGCAGAGAGAGGTTTGCGTAAGTTCTTGTTAAATAAGCAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9887.16 Da        Isoelectric Point: 9.7281

>AT223114 WP_010302402.1 NZ_CP086369:2568483-2568749 [Pectobacterium versatile]
MKVTNSKQLSSYLKDVRITQKLSQGKVASKVGIRQDTVSSFEQHPDSTKLETFFKILSALNLELTVTPRNVDTANNEASV
ASSWKEEW

Download         Length: 267 bp

>AT223114 NZ_CP118530:1407837-1408094 [Vibrio harveyi]
ATGAAAGTAGAACTAGTTACATCACTCAAACGTCAAGCAACTAAGATTCTCGCCGATCTCCACGACACCAAAGAACCAGT
GTTAATTACTGAGCATGGTAAGCCATCCGCGTATCTCGTTGATGTTGATGACTACGAGTTTATGCAAAATCGTTTAGCTA
TTCTTGAGGGTATTGCACGAGGTGAGCGTGCACTAGCTGACGGTAAAGTGGTAAGTCATGATGAAGCCAAGGTCAAAATG
TCAAAATGGCTGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References