Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 2435975..2436510 Replicon chromosome
Accession NZ_CP086369
Organism Pectobacterium versatile strain A73-S18-O15

Toxin (Protein)


Gene name relE Uniprot ID C6DJA0
Locus tag LLE50_RS11030 Protein ID WP_015842269.1
Coordinates 2436223..2436510 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q6DB37
Locus tag LLE50_RS11025 Protein ID WP_010281712.1
Coordinates 2435975..2436226 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LLE50_RS10995 (LLE50_10990) 2431402..2431728 + 327 WP_130621235.1 helix-turn-helix domain-containing protein -
LLE50_RS11000 (LLE50_10995) 2431713..2432027 + 315 WP_130621236.1 HipA N-terminal domain-containing protein -
LLE50_RS11005 (LLE50_11000) 2432024..2433064 + 1041 WP_125232112.1 HipA domain-containing protein -
LLE50_RS11010 (LLE50_11005) 2433125..2433748 - 624 WP_039474438.1 LysE family translocator -
LLE50_RS11015 (LLE50_11010) 2434026..2434781 + 756 WP_130621237.1 thiol:disulfide interchange protein DsbG -
LLE50_RS11020 (LLE50_11015) 2434815..2435720 - 906 WP_130621238.1 siderophore-interacting protein -
LLE50_RS11025 (LLE50_11020) 2435975..2436226 + 252 WP_010281712.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LLE50_RS11030 (LLE50_11025) 2436223..2436510 + 288 WP_015842269.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LLE50_RS11035 (LLE50_11030) 2436702..2437661 - 960 WP_103943153.1 bacteriophage abortive infection AbiH family protein -
LLE50_RS11040 (LLE50_11035) 2437663..2438763 - 1101 WP_103943155.1 PIN domain-containing protein -
LLE50_RS11045 (LLE50_11040) 2439040..2440392 - 1353 WP_010296544.1 glutathione-disulfide reductase -
LLE50_RS11050 (LLE50_11045) 2440521..2441363 - 843 WP_103160431.1 23S rRNA (adenine(2030)-N(6))-methyltransferase RlmJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11074.15 Da        Isoelectric Point: 10.3527

>T223113 WP_015842269.1 NZ_CP086369:2436223-2436510 [Pectobacterium versatile]
MSYSVKFREDALKEWLKLDKTIQQQFAKKLKKCCENPHIPSAKLRGMKDCYKIKLRASGFRLVYEVIDDVLIIAVVAVGK
RERSGVYHLASERMR

Download         Length: 288 bp

>T223113 NZ_CP118530:c1387671-1387381 [Vibrio harveyi]
ATGACCTATAAACTCGACTTTAAAAAGAGCGCCCTCAAAGAGTGGAAAAAGCTTGGTTCTACTCTGCAACAACAATTTAA
GAAAAAGCTAATCGAGCGCTTAGATAACCCACATGTTCCGGCTTCAAAATTGTCTGGAGCTGACAACATGTATAAAATTA
AGTTGCGTCAATCGGGCTACCGTCTCGTCTACAAAGTTGAAGACGATGTGATCATTGTAACCGTCCTAGCAGTTGGAAAG
CGCGAACGTAGCGATGTTTACCGTAAAGCCATGAAAAGGTTAGATGACTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9117.47 Da        Isoelectric Point: 4.0637

>AT223113 WP_010281712.1 NZ_CP086369:2435975-2436226 [Pectobacterium versatile]
MPNIILSDTSASVSELKKNPMATVNAGDGLPVAILNRNQPAFYCIPADLYEKMLDALDDQELVKLIGERKNQPLVDVDLD
SFL

Download         Length: 252 bp

>AT223113 NZ_CP118530:c1387909-1387661 [Vibrio harveyi]
ATGACCACTAGAATTTTAGCCGATGTTGCTGCAAGCATTACTGAGTTGAAAGCTAACCCTATGAAAGTTGCAACTAGTGC
TTACGGCGAACCTGTAGCTGTATTAAACCGAAATGAACCAGCATTTTATTGCGTACCTGCCGAAGCGTACGAAATGATGA
TGGACAGACTCGAAGATCTTGAACTACTCGCTATCGCTAAAGAGCGTGAATCTGAAGAGAGCATTTCGGTAAATATTGAT
GACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S0XQ75

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2EZP0

References