Detailed information of TA system TA223108

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 3125681..3127280
• Replicon: chromosome
• Accession: NZ_CP086368
• Organism: Bordetella pertussis CS

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: Q7VVM6
• Locus tag: LMF30_RS15110
• Protein ID: WP_003816876.1
• Coordinates: 3125681..3127021 (-)
• Length: 447 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: LMF30_RS15115
• Protein ID: WP_019247974.1
• Coordinates: 3127023..3127280 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LMF30_RS15090 (LMF30_15095)	3120907..3121710	-	804	WP_019248072.1	IclR family transcriptional regulator	-
LMF30_RS15095 (LMF30_15100)	3122143..3123221	-	1079	Protein_2969	tellurite resistance/C4-dicarboxylate transporter family protein	-
LMF30_RS15100 (LMF30_15105)	3123453..3124883	-	1431	WP_019247976.1	MFS transporter	-
LMF30_RS15105 (LMF30_15110)	3124896..3125585	+	690	WP_010931038.1	TetR/AcrR family transcriptional regulator	-
LMF30_RS15110 (LMF30_15115)	3125681..3127021	-	1341	WP_003816876.1	type II toxin-antitoxin system HipA family toxin	Toxin
LMF30_RS15115 (LMF30_15120)	3127023..3127280	-	258	WP_019247974.1	helix-turn-helix transcriptional regulator	Antitoxin
LMF30_RS15120 (LMF30_15125)	3127634..3129226	-	1593	WP_010931040.1	glutamine-hydrolyzing GMP synthase	-
LMF30_RS15125 (LMF30_15130)	3129323..3130783	-	1461	WP_003812368.1	IMP dehydrogenase	-
LMF30_RS15130 (LMF30_15135)	3131006..3131617	+	612	WP_010931041.1	DUF2239 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (10-112)

Antitoxin

• Cro/C1-type helix-turn-helix domain (18-70)

Sequences

Toxin

Protein

• Length: 447 a.a.
• Molecular weight: 49632.79 Da
• Isoelectric Point: 7.4158

>T223108 WP_003816876.1 NZ_CP086368:c3127021-3125681 [Bordetella pertussis CS]
MGRRSHSRSLSIWTNGVRVGRWTVPARGEMELQYDVDWVRADVGRPLSLSLPFNLQNLPLKGERVANYFDNLLPDSDAIR
RRVAERFRTGSVDPFDLLKAIGRDCVGAVQILEDEEIPEGFDRIEGVPLSEEDIERHLIETVTPRAFAAGRDPDADFRIS
LAGAQEKTAFLWWGGQWLAPRGATSTSHIFKLPLGLVGGRRADFSTSVDNEWLCLKLLKAYGLDVAEASIATFGQQRVLV
VERFDRRVAPNGQWLMRLPQEDFCQVEGCSPLRKYENEGGPGLKALFATLRQSVNAAVDMRTLMAAQILFWLLRAPDGHA
KNFSIQLLPRGRFQLTRLYDVMSAYPVLGDGANQWSPFEIKLAMALIGKNRHYEMHGIQRRHFNSTAQKVGYGPTAEPII
EDLLARTPAIIAAVQADLPQDFSPRVADSVLGGLAQAAKSLGAMMP

Nucleotide

• Length: 1341 bp

>T223108 NZ_CP118496:c4722482-4722183 [Pseudoalteromonas rhizosphaerae]
ATGGCTGAAATGATCTGGACAAATCCTGCTCTGGAAGATTTAAACGATATCGCTGAATATATTGCATTGAGTAACTTGCT
GTCAGCTAAAAAGTTGGTGGTGAAAATCATTGCTAAAGTTGAACGCCTTGAAGAGTTCCCTGAATCAGGGAAAACACCGA
TTGAACTATCAAATCTGAATTATCGTGAAGTGATAGTTAATCCTTGTCGTATATTTTACAAAATAGACAATGATAAGGTT
TTTATTTTACACATAATGAGACAAGAGCGTGATTTACGTAAGTTCTTGTTGCAAATGTAG

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 8815.04 Da
• Isoelectric Point: 7.1642

>AT223108 WP_019247974.1 NZ_CP086368:c3127280-3127023 [Bordetella pertussis CS]
MPPPSQPLLTTGQLGAVLQAARKAQGLTQSALASRIGLSQSRVSHLELNAHQLSVEQLLAWCAALGLELTIATRGSPAGS
SDADW

Nucleotide

• Length: 258 bp

>AT223108 NZ_CP118496:c4722727-4722470 [Pseudoalteromonas rhizosphaerae]
ATGAGAGTAGAGTTAGTAACAACATTGAAACGCCAAGCGACGAAAATATTATCTGAACTGCATTTAACTAAAGAGCCCGT
ATTAATCACCGAACATGGGCAACCGTCAGCGTATCTTGTTGATGTTGATGACTTCGAATTCATGCAAAAACGTATGCAAA
TCCTTGAGGCGTTAGCTAAAGGCGAGCAGGCAATAAGTAGAGGAGAAACTACGTCAAATATTGAAGCTAAAGAGAAAATG
AATAAATGGCTGAAATGA

Structures

Toxin

• AlphaFold DB: Q7VVM6