Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 2776663..2777183 Replicon chromosome
Accession NZ_CP086349
Organism Clavibacter michiganensis subsp. nebraskensis strain CIBA

Toxin (Protein)


Gene name parE Uniprot ID M5BDX6
Locus tag LIX19_RS13130 Protein ID WP_015491236.1
Coordinates 2776663..2776953 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A399PXI2
Locus tag LIX19_RS13135 Protein ID WP_041465310.1
Coordinates 2776950..2777183 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LIX19_RS13120 (LIX19_002622) 2774612..2776210 + 1599 WP_015491235.1 class I SAM-dependent methyltransferase -
LIX19_RS13125 (LIX19_002624) 2776369..2776623 + 255 Protein_2579 helix-turn-helix transcriptional regulator -
LIX19_RS13130 (LIX19_002625) 2776663..2776953 - 291 WP_015491236.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LIX19_RS13135 (LIX19_002626) 2776950..2777183 - 234 WP_041465310.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
LIX19_RS13140 (LIX19_002627) 2777295..2777495 - 201 WP_015491238.1 hypothetical protein -
LIX19_RS13145 (LIX19_002628) 2777511..2777822 - 312 WP_236685126.1 antitoxin VbhA family protein -
LIX19_RS13150 (LIX19_002629) 2777830..2778894 + 1065 WP_045929310.1 LD-carboxypeptidase -
LIX19_RS13155 (LIX19_002630) 2779071..2779430 + 360 WP_045929311.1 hypothetical protein -
LIX19_RS13160 (LIX19_002631) 2779591..2780106 + 516 WP_041465311.1 hypothetical protein -
LIX19_RS13165 (LIX19_002632) 2780253..2781290 + 1038 WP_045929312.1 DUF1266 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-92)

Antitoxin

Antitoxin ParD

(4-72)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11338.63 Da        Isoelectric Point: 6.4832

>T223104 WP_015491236.1 NZ_CP086349:c2776953-2776663 [Clavibacter michiganensis subsp. nebraskensis]
VKPHRLTPAATKDLSEIWDYTEERWDADQAETYVREIGAAIRRVAEDPTRGRDCGDIRPGYRRYSIESHTVYYVDRPETV
DVIRILHQRMDPSRHL

Download         Length: 291 bp

>T223104 NZ_CP118495:c1274499-1273753 [Bacillus velezensis]
ATGCTTTTGTTTTTTCAGATCATGGTGTGGACGATGGCGGCCGCACTCATTTTATATGTGTACGCATCCTGGCGGTATGA
AGCAAAGGTAAAAGAAAAAATGTTTGCCATCCGTAAAACGTGGTATTTACTATTTGTAGTAGGCGCCATGGTCTATTGGA
CATATGATCCCGAATCGCTCTTTGCCGCATGGAGACAATATTTGATTGTTGCCGTCTGCTTTGCCCTTATTGATGCGTTT
ATCTTTTTGAGCGCGTATATCAAAAAGCTCGCCGGCAATGAATTAGAGACGGATACGCGGGAAATTTTAGAAGAAAATAA
CGAAATGCTTCACTCCTATCTTGAAAAACTGAAAACCTATCAATATCTGTTGAAAAATGAACCGATCCATGTATATTATG
GAAGTACAGAAGCTTATGCGGAAGGCATCAGCAGACTGCTGGCCGCTTATGGAGAAAAAATGAATGTCACGGCTTCCTTG
TGCGACTATTCCGCACAATCGGATAAGGACCGCTTGACGGAGCATATGCCTGATGCGGCGGACGTTCAGTCCCGTCTTAA
CCGTAAAGACGTCTACTATGATCAAAAAGGCAGGCTTGTGCTTATTCCGTTTACAGTCCAGGACCGCCATTACGTGATCA
AACTCACGTCGGAAAACCTGTTGACGGAATTCGATTATTTGCTTTTCACATCGCTAACGAGCATTTATGATTTAATGCTG
CCAATAGAAGAGGAAGGTGACGGTTAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8268.18 Da        Isoelectric Point: 4.4000

>AT223104 WP_041465310.1 NZ_CP086349:c2777183-2776950 [Clavibacter michiganensis subsp. nebraskensis]
MAQNTSISLDGHFTGFLAREVESGRYRSASEVVRAGLRLLEDQETQLEALRAALVAGEASGEAAPFDLDAFIADKRA

Download         Length: 234 bp

>AT223104 NZ_CP118495:c1273752-1273582 [Bacillus velezensis]
ATGGAGCAGGCATTTCAAAACGGGCAGCCGGAACAAAGAGCGAAACCGTTCAAAATGTTTAAAAAACGTTCAATGACAAG
TATCGCAAGTTACCAGGTCAGCCCTCATACCGCCAGAATTTTCAAAGAAAACGAGCGGCTGATTGACAAGTATAAACAAA
AAAAAGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB M5BDX6

Antitoxin

Source ID Structure
AlphaFold DB A0A399PXI2

References