Detailed information of TA system TA022310

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /ElaA(toxin)
• Location: 37893..38742
• Replicon: plasmid pS18501
• Accession: NC_009661
• Organism: Shewanella baltica OS185

Toxin (Protein)

• Gene name: -
• Uniprot ID: B8EFS1
• Locus tag: SHEW185_RS22880
• Protein ID: WP_011979514.1
• Coordinates: 37893..38402 (+)
• Length: 170 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: SHEW185_RS22885
• Protein ID: WP_011979515.1
• Coordinates: 38515..38742 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SHEW185_RS22850	34350..34805	+	456	WP_011979508.1	type II toxin-antitoxin system HicB family antitoxin	-
SHEW185_RS22855	34807..35295	+	489	WP_011979509.1	hypothetical protein	-
SHEW185_RS22860	35326..35547	+	222	WP_011979510.1	hypothetical protein	-
SHEW185_RS22865	36223..36846	+	624	WP_012589009.1	hypothetical protein	-
SHEW185_RS22870	36848..37249	+	402	WP_011979512.1	hypothetical protein	-
SHEW185_RS22875	37619..37912	+	294	WP_011979513.1	DUF1778 domain-containing protein	-
SHEW185_RS22880	37893..38402	+	510	WP_011979514.1	GNAT family N-acetyltransferase	Toxin
SHEW185_RS22885	38515..38742	+	228	WP_011979515.1	hypothetical protein	Antitoxin
SHEW185_RS22890	39317..40315	+	999	WP_011979516.1	DUF1738 domain-containing protein	-
SHEW185_RS22895	40364..40663	+	300	WP_011979517.1	hypothetical protein	-
SHEW185_RS22900	41221..41580	+	360	WP_006087379.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..83224	83224

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (80-143)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 170 a.a.
• Molecular weight: 19129.15 Da
• Isoelectric Point: 8.3399

>T22310 WP_011979514.1 NC_009661:37893-38402 [Shewanella baltica OS185]
MKITQFDKNEHDRKSFDCGNTELNNYLKCISGQHEKKDISRTYVLTSELNPSHIKGYYSIAVAQVSLCELPTEIAKKYPS
EITCSLIGRMAVNHTCQRQGLGSILLIDAIKRIIQASSAIPIPMIIVQAKNEDARRFYSEFGFVSFPDNYLKLMMTLAHA
KAMLKEAEH

Nucleotide

• Length: 510 bp

>T22310 NC_009661:37893-38402 [Shewanella baltica OS185]
ATGAAAATTACCCAATTTGATAAAAATGAGCATGACCGTAAGAGTTTTGATTGTGGGAATACAGAGCTAAACAATTACCT
GAAATGCATTTCAGGTCAGCATGAAAAGAAAGATATTTCAAGAACATATGTTCTTACTTCAGAGTTAAATCCTTCACACA
TAAAAGGTTATTACTCTATTGCGGTAGCTCAGGTATCACTTTGTGAGTTACCAACCGAAATAGCTAAAAAATATCCATCT
GAAATAACGTGTAGCTTGATAGGTCGAATGGCTGTTAACCATACCTGTCAAAGACAAGGGCTTGGCTCAATATTGCTTAT
AGACGCAATCAAACGAATTATCCAAGCTTCCAGTGCTATCCCCATCCCTATGATTATTGTTCAAGCAAAGAACGAAGATG
CTAGACGTTTTTATAGTGAGTTTGGTTTTGTATCCTTTCCTGATAATTATTTGAAACTCATGATGACACTGGCCCATGCT
AAAGCGATGTTGAAAGAAGCCGAACATTAA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8335.43 Da
• Isoelectric Point: 3.8074

>AT22310 WP_011979515.1 NC_009661:38515-38742 [Shewanella baltica OS185]
MMQNAMTFKGYHGSVEISPEDNILFGQVLFISPLINYEAETAKELEQAFQEAINAYLADCVQQDIPPEKALEGIA

Nucleotide

• Length: 228 bp

>AT22310 NC_009661:38515-38742 [Shewanella baltica OS185]
ATGATGCAAAATGCAATGACATTTAAGGGTTATCACGGCTCTGTAGAAATCAGCCCAGAGGATAATATTCTGTTTGGGCA
GGTGTTATTCATTTCACCGTTGATCAACTATGAGGCCGAAACCGCCAAAGAGTTAGAGCAAGCATTTCAAGAGGCGATTA
ACGCTTATCTTGCTGATTGTGTTCAACAGGACATTCCGCCAGAGAAAGCCTTGGAAGGGATAGCTTAA

Structures

Toxin

• AlphaFold DB: A9L6I1