Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /ElaA-DUF1778
Location 37619..38402 Replicon plasmid pS18501
Accession NC_009661
Organism Shewanella baltica OS185

Toxin (Protein)


Gene name - Uniprot ID B8EFS1
Locus tag SHEW185_RS22880 Protein ID WP_011979514.1
Coordinates 37893..38402 (+) Length 170 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID B8EFS2
Locus tag SHEW185_RS22875 Protein ID WP_011979513.1
Coordinates 37619..37912 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SHEW185_RS22850 34350..34805 + 456 WP_011979508.1 type II toxin-antitoxin system HicB family antitoxin -
SHEW185_RS22855 34807..35295 + 489 WP_011979509.1 hypothetical protein -
SHEW185_RS22860 35326..35547 + 222 WP_011979510.1 hypothetical protein -
SHEW185_RS22865 36223..36846 + 624 WP_012589009.1 hypothetical protein -
SHEW185_RS22870 36848..37249 + 402 WP_011979512.1 hypothetical protein -
SHEW185_RS22875 37619..37912 + 294 WP_011979513.1 DUF1778 domain-containing protein Antitoxin
SHEW185_RS22880 37893..38402 + 510 WP_011979514.1 GNAT family N-acetyltransferase Toxin
SHEW185_RS22885 38515..38742 + 228 WP_011979515.1 hypothetical protein -
SHEW185_RS22890 39317..40315 + 999 WP_011979516.1 DUF1738 domain-containing protein -
SHEW185_RS22895 40364..40663 + 300 WP_011979517.1 hypothetical protein -
SHEW185_RS22900 41221..41580 + 360 WP_006087379.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..83224 83224


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(80-143)

Antitoxin

Vibrio phage ICP1, Orf50

(2-89)


Sequences

Toxin        


Download         Length: 170 a.a.        Molecular weight: 19129.15 Da        Isoelectric Point: 8.3399

>T22309 WP_011979514.1 NC_009661:37893-38402 [Shewanella baltica OS185]
MKITQFDKNEHDRKSFDCGNTELNNYLKCISGQHEKKDISRTYVLTSELNPSHIKGYYSIAVAQVSLCELPTEIAKKYPS
EITCSLIGRMAVNHTCQRQGLGSILLIDAIKRIIQASSAIPIPMIIVQAKNEDARRFYSEFGFVSFPDNYLKLMMTLAHA
KAMLKEAEH

Download         Length: 510 bp

>T22309 NC_009661:37893-38402 [Shewanella baltica OS185]
ATGAAAATTACCCAATTTGATAAAAATGAGCATGACCGTAAGAGTTTTGATTGTGGGAATACAGAGCTAAACAATTACCT
GAAATGCATTTCAGGTCAGCATGAAAAGAAAGATATTTCAAGAACATATGTTCTTACTTCAGAGTTAAATCCTTCACACA
TAAAAGGTTATTACTCTATTGCGGTAGCTCAGGTATCACTTTGTGAGTTACCAACCGAAATAGCTAAAAAATATCCATCT
GAAATAACGTGTAGCTTGATAGGTCGAATGGCTGTTAACCATACCTGTCAAAGACAAGGGCTTGGCTCAATATTGCTTAT
AGACGCAATCAAACGAATTATCCAAGCTTCCAGTGCTATCCCCATCCCTATGATTATTGTTCAAGCAAAGAACGAAGATG
CTAGACGTTTTTATAGTGAGTTTGGTTTTGTATCCTTTCCTGATAATTATTTGAAACTCATGATGACACTGGCCCATGCT
AAAGCGATGTTGAAAGAAGCCGAACATTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10811.39 Da        Isoelectric Point: 10.0024

>AT22309 WP_011979513.1 NC_009661:37619-37912 [Shewanella baltica OS185]
MKSMTNERITTRVSIESKELLEKAAALAGYASINSFIANTMISEAKRLITQEHFLVLSKNDALAFVNALDAPVKSNSRFL
NAARKHKETVNNENYPI

Download         Length: 294 bp

>AT22309 NC_009661:37619-37912 [Shewanella baltica OS185]
ATGAAAAGTATGACAAATGAACGCATTACCACTCGGGTAAGCATTGAGTCAAAAGAACTATTAGAGAAAGCGGCTGCGCT
CGCTGGTTATGCCAGTATTAACAGTTTTATTGCGAATACAATGATTTCAGAAGCGAAAAGATTGATCACACAAGAGCATT
TTCTGGTGTTATCAAAAAATGATGCTTTAGCTTTTGTGAACGCTTTAGATGCACCCGTTAAAAGTAACAGTCGGTTTCTT
AATGCCGCGCGTAAGCATAAGGAAACGGTAAACAATGAAAATTACCCAATTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A9L6I1

Antitoxin

Source ID Structure
AlphaFold DB A0A380BY85

References