223071

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3463203..3463821 Replicon chromosome
Accession NZ_CP086340
Organism Escherichia coli strain ESY003

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag C5N08_RS16655 Protein ID WP_001291435.1
Coordinates 3463603..3463821 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag C5N08_RS16650 Protein ID WP_000344800.1
Coordinates 3463203..3463577 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C5N08_RS16640 (3458292) 3458292..3459485 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
C5N08_RS16645 (3459508) 3459508..3462657 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
C5N08_RS16650 (3463203) 3463203..3463577 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
C5N08_RS16655 (3463603) 3463603..3463821 + 219 WP_001291435.1 HHA domain-containing protein Toxin
C5N08_RS16660 (3463993) 3463993..3464544 + 552 WP_000102564.1 maltose O-acetyltransferase -
C5N08_RS16665 (3464660) 3464660..3465130 + 471 WP_000136192.1 YlaC family protein -
C5N08_RS16670 (3465294) 3465294..3466844 + 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
C5N08_RS16675 (3466886) 3466886..3467239 - 354 WP_000878140.1 DUF1428 domain-containing protein -
C5N08_RS16685 (3467618) 3467618..3467929 + 312 WP_000409911.1 MGMT family protein -
C5N08_RS16690 (3467960) 3467960..3468532 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T223071 WP_001291435.1 NZ_CP086340:3463603-3463821 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T223071 NZ_CP118398:1954618-1954720 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCGTTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT223071 WP_000344800.1 NZ_CP086340:3463203-3463577 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT223071 NZ_CP118398:c1954727-1954582 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAACGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References