Detailed information of TA system TA022307

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PP_4151-4152/excise(antitoxin)
• Location: 3035135..3036173
• Replicon: chromosome
• Accession: NC_009659
• Organism: Janthinobacterium sp. Marseille

Toxin (Protein)

• Gene name: PP_4152
• Uniprot ID: -
• Locus tag: MMA_RS13940
• Protein ID: WP_012080537.1
• Coordinates: 3035135..3035707 (-)
• Length: 191 a.a.

Antitoxin (Protein)

• Gene name: PP_4151
• Uniprot ID: A6T1I0
• Locus tag: MMA_RS13945
• Protein ID: WP_012080538.1
• Coordinates: 3035712..3036173 (-)
• Length: 154 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MMA_RS13915	3030376..3030747	-	372	WP_041296611.1	hypothetical protein	-
MMA_RS13920	3030747..3032135	-	1389	WP_012080533.1	recombinase family protein	-
MMA_RS13925	3032132..3032584	-	453	WP_012080534.1	DUF2924 domain-containing protein	-
MMA_RS13930	3032584..3032775	-	192	WP_041296612.1	hypothetical protein	-
MMA_RS13935	3032863..3035115	-	2253	WP_012080536.1	hypothetical protein	-
MMA_RS13940	3035135..3035707	-	573	WP_012080537.1	PIN domain-containing protein	Toxin
MMA_RS13945	3035712..3036173	-	462	WP_012080538.1	helix-turn-helix domain-containing protein	Antitoxin
MMA_RS19665	3036402..3036665	+	264	WP_012080539.1	hypothetical protein	-
MMA_RS13955	3036676..3037158	+	483	WP_012080540.1	hypothetical protein	-
MMA_RS13960	3037155..3038000	+	846	WP_012080541.1	ATP-binding protein	-
MMA_RS13965	3038006..3038644	+	639	WP_012080542.1	hypothetical protein	-
MMA_RS13970	3038656..3039510	+	855	WP_012080543.1	P63C domain-containing protein	-
MMA_RS13975	3039507..3039983	+	477	WP_012080544.1	hypothetical protein	-
MMA_RS13980	3039980..3040717	+	738	WP_012080545.1	hypothetical protein	-
MMA_RS13985	3040714..3040974	+	261	WP_012080546.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	ccmF	3023166..3148765	125599

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (7-114)

Antitoxin

• Helix-turn-helix domain, group 17 (83-130)

Sequences

Toxin

Protein

• Length: 191 a.a.
• Molecular weight: 21445.52 Da
• Isoelectric Point: 6.2663

>T22307 WP_012080537.1 NC_009659:c3035707-3035135 [Janthinobacterium sp. Marseille]
MSSHFTVVYDACTLYPAPLRDLLMHLALSDLFRARWSNMIHDEWIRNVHANRPDLSLERLERTRAHMNHAVRDCVVTGFE
YMIPSINLPDPDDRHVVAAAIHSGASLIITFNLKDFPDEALKPYNLAAQHPDDFIVDLLDLHPAGVLEAAASHRRSLKSP
PKTADEYLDTLLAQGLTQSVAVMRQWTVAM

Nucleotide

• Length: 573 bp

>T22307 NC_009659:c3035707-3035135 [Janthinobacterium sp. Marseille]
ATGAGTTCACATTTCACGGTCGTCTATGACGCCTGCACCCTCTATCCGGCACCGCTGCGTGATTTGCTGATGCATCTGGC
GCTCTCGGATTTATTCCGGGCGCGCTGGAGCAACATGATTCACGACGAGTGGATACGTAATGTCCACGCGAATCGCCCCG
ATCTCAGTCTTGAGCGTCTGGAGCGGACACGCGCCCACATGAACCATGCGGTGCGTGACTGTGTCGTCACCGGCTTCGAG
TACATGATCCCGTCGATCAACCTGCCTGATCCGGACGACCGGCACGTGGTGGCGGCTGCTATTCATTCCGGGGCCAGCCT
GATCATCACATTCAATCTGAAAGACTTTCCCGACGAGGCGCTCAAGCCTTACAACCTTGCGGCCCAGCACCCGGACGATT
TCATCGTCGATCTTCTGGATCTGCACCCGGCAGGCGTTCTGGAAGCAGCGGCCAGTCACCGGCGGTCATTGAAATCACCA
CCGAAAACAGCAGACGAATACTTGGACACCTTGCTCGCGCAAGGTTTGACTCAATCGGTGGCGGTGATGCGCCAATGGAC
TGTGGCCATGTAA

Antitoxin

Protein

• Length: 154 a.a.
• Molecular weight: 17000.52 Da
• Isoelectric Point: 6.8850

>AT22307 WP_012080538.1 NC_009659:c3036173-3035712 [Janthinobacterium sp. Marseille]
MNAPAITKTLPSAEDIALARESGRALSTVLLTRSETQQIDFHDDKGAVRAVRIPTSALRLLLEVLTEIGQGNAVSIIPIH
AELTTQEAADVLNVSRPFLVQLLEKGEMPFHKIGTHRRVRYQDVISYKKRIDTERRKALEELAAEAQELGMGY

Nucleotide

• Length: 462 bp

>AT22307 NC_009659:c3036173-3035712 [Janthinobacterium sp. Marseille]
ATGAACGCTCCCGCCATCACCAAAACGCTGCCGTCAGCAGAGGACATCGCACTGGCCCGAGAGTCGGGTCGGGCGCTGTC
GACCGTGCTTCTGACCCGCTCCGAAACCCAGCAGATCGATTTCCATGACGACAAGGGGGCTGTGCGTGCTGTACGCATCC
CCACCTCGGCACTGCGGCTGCTGCTTGAAGTGTTGACCGAAATTGGCCAGGGCAATGCCGTGTCAATCATCCCAATCCAC
GCCGAACTGACCACGCAGGAAGCCGCCGACGTGCTCAACGTCTCGCGCCCCTTCCTCGTGCAGTTGCTGGAAAAAGGTGA
GATGCCGTTCCACAAGATCGGCACCCATCGCCGCGTTCGCTACCAGGATGTGATCTCGTACAAGAAGCGCATCGATACCG
AACGCCGCAAAGCGCTGGAGGAATTGGCTGCAGAGGCGCAAGAACTCGGTATGGGGTATTGA

Structures

Antitoxin

• AlphaFold DB: A6T1I0