Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1872176..1873008 Replicon chromosome
Accession NZ_CP086340
Organism Escherichia coli strain ESY003

Toxin (Protein)


Gene name yeeV Uniprot ID A7ZVJ9
Locus tag C5N08_RS08885 Protein ID WP_000854765.1
Coordinates 1872176..1872550 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1NM52
Locus tag C5N08_RS08890 Protein ID WP_001295723.1
Coordinates 1872640..1873008 (-) Length 123 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C5N08_RS08845 (1867561) 1867561..1867827 - 267 WP_087757644.1 EutP/PduV family microcompartment system protein -
C5N08_RS08850 (1868197) 1868197..1868586 - 390 WP_001445118.1 IS110 family transposase -
C5N08_RS08855 (1868775) 1868775..1868999 - 225 Protein_1735 transposase -
C5N08_RS08860 (1869080) 1869080..1869484 + 405 WP_000839179.1 transposase -
C5N08_RS08865 (1869481) 1869481..1869828 + 348 WP_000612626.1 IS66 family insertion sequence element accessory protein TnpB -
C5N08_RS08870 (1869877) 1869877..1871416 + 1540 Protein_1738 IS66-like element ISEc22 family transposase -
C5N08_RS08875 (1871847) 1871847..1871927 - 81 Protein_1739 hypothetical protein -
C5N08_RS08880 (1872027) 1872027..1872179 - 153 Protein_1740 DUF5983 family protein -
C5N08_RS08885 (1872176) 1872176..1872550 - 375 WP_000854765.1 TA system toxin CbtA family protein Toxin
C5N08_RS08890 (1872640) 1872640..1873008 - 369 WP_001295723.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
C5N08_RS08895 (1873171) 1873171..1873392 - 222 WP_000692341.1 DUF987 domain-containing protein -
C5N08_RS08900 (1873455) 1873455..1873931 - 477 WP_001186774.1 RadC family protein -
C5N08_RS08905 (1873947) 1873947..1874420 - 474 WP_000855059.1 antirestriction protein -
C5N08_RS08910 (1874762) 1874762..1875580 - 819 WP_001234729.1 DUF932 domain-containing protein -
C5N08_RS08915 (1875698) 1875698..1875893 - 196 Protein_1747 DUF905 family protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-112)

Antitoxin

(18-117)


Sequences


Toxin        


Download         Length: 125 a.a.        Molecular weight: 13970.98 Da        Isoelectric Point: 7.2909

>T223060 WP_000854765.1 NZ_CP086340:c1872550-1872176 [Escherichia coli]
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYSLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGASSQLINSIDILRARRATGLMTRHNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T223060 NZ_CP118384:c174657-174172 [Enterobacter hormaechei]
GTGGGACGTGTAACAGCACCAGAACCATTATCCAGCTCCCATCAACTAGCAGAGTTCGTCAGTGGTGAGGCAGTACTTGA
TGACTGGCTTAAACAGAGGGGATTAAAAAACCAAGCTCTTGGTGCAGCACGAACGTTCGTCGTTTGTAAAAGAGACACTA
AACAGGTTGTCGGTTTTTACTCTCTGGCCACCGGCAGCGTTAACCACGTGGAAGCAATGGGAAGCCTCAGGCGCAATATG
CCAGATCCAATTCCCGTAATCATACTTGCTCGCCTGGCAGTTGATGTTTCATACCGTGGCCAAGGGCTCGGGGCCGATTT
ACTGCATGATGCAGTTCTGCGCTGTTACCGTGTAGCTGAGAATATTGGAGTCCGTGCGATTATGGTTCATGCACTGACTG
AAGAAGCCAAAAACTTTTATCTTCACCATGGCTTTAAGGCATCACAAACTCAGGAACGGACATTGTTTTTAAAGTTACCA
CAGTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13592.40 Da        Isoelectric Point: 6.6255

>AT223060 WP_001295723.1 NZ_CP086340:c1873008-1872640 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT223060 NZ_CP118384:c174911-174645 [Enterobacter hormaechei]
ATGAAATCAGATGTTCAGCTCAACCTTAGAGCTAAAGAATCTCAAAGAGCACTTATTGATGCTGCAGCAGAGATTCTCCA
TAAATCACGCACGGACTTCATCCTGGAAATGGCATGTCAGGCTGCGGAGAATGTGATCCTCGATCGTCGCGTATTTAATT
TTAACGATGAGCAGTATGCAGAGTTTATCGATATGCTCGATGCACCGGTTTCGGATGAGGCGGCTATTGATAAACTTCTG
GCAAGGAAACCTCAGTGGGACGTGTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A7ZVJ9


Antitoxin

Source ID Structure
AlphaFold DB S1NM52

References