Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 796706..797538 Replicon chromosome
Accession NZ_CP086340
Organism Escherichia coli strain ESY003

Toxin (Protein)


Gene name yeeV Uniprot ID A7ZVJ9
Locus tag C5N08_RS03870 Protein ID WP_000854765.1
Coordinates 796706..797080 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1NM52
Locus tag C5N08_RS03875 Protein ID WP_001295723.1
Coordinates 797170..797538 (-) Length 123 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C5N08_RS03835 (791784) 791784..792383 + 600 WP_001255034.1 type II secretion system minor pseudopilin GspJ -
C5N08_RS03840 (792386) 792386..793363 + 978 WP_000633209.1 type II secretion system minor pseudopilin GspK -
C5N08_RS03845 (793360) 793360..794538 + 1179 WP_000094991.1 type II secretion system protein GspL -
C5N08_RS03850 (794540) 794540..795076 + 537 WP_000942785.1 GspM family type II secretion system protein YghD -
C5N08_RS03855 (795357) 795357..796199 - 843 WP_022645115.1 DUF4942 domain-containing protein -
C5N08_RS03860 (796284) 796284..796478 - 195 WP_024181941.1 DUF957 domain-containing protein -
C5N08_RS03865 (796503) 796503..796706 - 204 WP_001398797.1 DUF5983 family protein -
C5N08_RS03870 (796706) 796706..797080 - 375 WP_000854765.1 TA system toxin CbtA family protein Toxin
C5N08_RS03875 (797170) 797170..797538 - 369 WP_001295723.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
C5N08_RS03880 (797701) 797701..797922 - 222 WP_000692341.1 DUF987 domain-containing protein -
C5N08_RS03885 (797985) 797985..798461 - 477 WP_001186774.1 RadC family protein -
C5N08_RS03890 (798477) 798477..798956 - 480 WP_057109541.1 antirestriction protein -
C5N08_RS03895 (799222) 799222..800040 - 819 WP_001175165.1 DUF932 domain-containing protein -
C5N08_RS03900 (800130) 800130..800363 - 234 WP_001278293.1 DUF905 family protein -
C5N08_RS03905 (800369) 800369..801046 - 678 WP_001097302.1 hypothetical protein -
C5N08_RS03910 (801194) 801194..801874 - 681 WP_001282921.1 WYL domain-containing protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-112)

Antitoxin

(18-117)


Sequences


Toxin        


Download         Length: 125 a.a.        Molecular weight: 13970.98 Da        Isoelectric Point: 7.2909

>T223056 WP_000854765.1 NZ_CP086340:c797080-796706 [Escherichia coli]
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYSLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGASSQLINSIDILRARRATGLMTRHNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T223056 NZ_CP118383:c3765511-3765125 [Enterobacter hormaechei]
ATGCAAACGAAATTACCCTTCATGCGGGCGGCATCGTCACGTCCGTCTCCCGTTGATGTCTGGCAGACTCTACTGACCTG
CCTGCTGGAACACCACTATGGTCTCACGCTTAACGATACGCCGTTCAGTGATGAACTGGTGATTCAGCAACATATCGACG
CGGGTATCTCGCTGGCCGATGCCCTGAATTTTATTGTTGAGAAGTATGAACTGGTCCGCACTGACCGGCCAGGCTTCAGC
ATCAGGGAGCAGTCTCCGTTTATTACGGCCTTTGATATTCTCCGGGCCAGAAAGGCTACAGGGCTGATGAACCGTGGCAC
GTATAAAGAGGTGACGGCTATTACCAGAGGACAACATCCGCAGGCCAGCACTTCAGGCAAGCGATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13592.40 Da        Isoelectric Point: 6.6255

>AT223056 WP_001295723.1 NZ_CP086340:c797538-797170 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT223056 NZ_CP118383:c3765924-3765565 [Enterobacter hormaechei]
TTGTCGAAGAAAACCACACTAACAACACATGATATCAGCGAGCCCTGGTGGGGGCTCAGACGCAGTATCTCCCCGTGTTT
TGGTGCCCGTCTGGTCCAGATGGGAAACCGCCTGCACTACCTGGCTGACCGCGCGAACTTTGATGGTCAGTTCTGCGATG
CAGATTTGCGCCATCTTGACCAGGCTTTCCCGGTATTGATGAAACAGCTGGAGTTAATGCTCACCAGCGGTGAACTGAAT
CCCCGCCACCAGCATGGCGTCACGCTGTATGCAAAAGGCCTGACCTGCGAGGCCGATACGCTCGGTTCGCATGGCTACGT
TTATATCGCGATTTATCCCGCTCCCGTCACCACAGAATAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A7ZVJ9


Antitoxin

Source ID Structure
AlphaFold DB S1NM52

References