Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 5219828..5220442 Replicon chromosome
Accession NC_009656
Organism Pseudomonas aeruginosa PA7

Toxin (Protein)


Gene name hicA Uniprot ID A6VBH9
Locus tag PSPA7_RS31520 Protein ID WP_071534354.1
Coordinates 5220260..5220442 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A140SDX7
Locus tag PSPA7_RS24210 Protein ID WP_012077229.1
Coordinates 5219828..5220232 (-) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PSPA7_RS24185 5215974..5216684 + 711 WP_012074129.1 hypothetical protein -
PSPA7_RS24190 5216681..5217601 + 921 WP_012074128.1 hypothetical protein -
PSPA7_RS24195 5217598..5218137 + 540 WP_012077226.1 hypothetical protein -
PSPA7_RS24200 5218137..5218829 + 693 WP_012077227.1 hypothetical protein -
PSPA7_RS24205 5218814..5219785 + 972 WP_012077228.1 hypothetical protein -
PSPA7_RS24210 5219828..5220232 - 405 WP_012077229.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
PSPA7_RS31520 5220260..5220442 - 183 WP_071534354.1 type II toxin-antitoxin system HicA family toxin Toxin
PSPA7_RS24215 5221150..5222052 - 903 WP_003155104.1 ZIP family metal transporter -
PSPA7_RS24220 5222119..5222733 - 615 WP_012077233.1 superoxide dismutase -
PSPA7_RS24225 5222746..5223195 - 450 WP_012077234.1 hypothetical protein -
PSPA7_RS24230 5223224..5224600 - 1377 WP_012077235.1 class II fumarate hydratase -
PSPA7_RS24235 5224593..5224988 - 396 WP_003155111.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 5186790..5220442 33652


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6702.74 Da        Isoelectric Point: 10.4826

>T22305 WP_071534354.1 NC_009656:c5220442-5220260 [Pseudomonas aeruginosa PA7]
MRSREVIDLLLEDGWYEVAVKGSHHQFKHPSKPGKVTVQHPSSTIPKGTLNNILKQAGLK

Download         Length: 183 bp

>T22305 NC_009656:c5220442-5220260 [Pseudomonas aeruginosa PA7]
ATGCGGAGTAGGGAAGTGATTGATTTGCTGTTGGAGGATGGCTGGTATGAAGTGGCGGTGAAAGGTAGCCACCACCAGTT
CAAACATCCTTCAAAGCCTGGAAAGGTGACGGTTCAACATCCGTCCTCGACGATACCGAAAGGAACCCTGAACAACATAC
TGAAACAAGCCGGCCTCAAGTGA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14670.54 Da        Isoelectric Point: 4.4315

>AT22305 WP_012077229.1 NC_009656:c5220232-5219828 [Pseudomonas aeruginosa PA7]
MKFPVVLHKDPDSDYGVTVPDVPGCFSAGATVSEALANVEEALALHFEGLVTDGEELPQPQDVDAHMKNPDFEGGVWAVV
DFDVTPYLGKAVRFNATLPEHLLQRIDERVKVDKRYQSRSGFLATAAMRELSVA

Download         Length: 405 bp

>AT22305 NC_009656:c5220232-5219828 [Pseudomonas aeruginosa PA7]
ATGAAATTCCCCGTGGTGTTACACAAAGACCCTGATTCTGACTATGGCGTGACTGTGCCCGATGTGCCGGGTTGCTTCTC
TGCCGGCGCTACGGTGTCCGAGGCCCTGGCCAATGTAGAAGAGGCGCTGGCCTTGCACTTCGAAGGCTTGGTTACGGACG
GCGAAGAGCTACCCCAGCCGCAGGACGTTGACGCCCATATGAAGAATCCGGACTTCGAAGGTGGCGTATGGGCGGTGGTT
GACTTCGACGTGACCCCGTACCTGGGCAAGGCCGTACGCTTTAATGCGACGCTCCCGGAACACCTTCTGCAGCGGATCGA
TGAGCGCGTGAAGGTGGATAAGCGCTATCAGTCTCGGTCGGGCTTTCTGGCAACAGCGGCGATGCGCGAACTGTCAGTGG
CGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6VBH9

Antitoxin

Source ID Structure
AlphaFold DB A0A140SDX7

References