Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 390359..390954 Replicon chromosome
Accession NZ_CP086338
Organism Escherichia coli strain EJN001

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag C5N09_RS01845 Protein ID WP_000239579.1
Coordinates 390604..390954 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag C5N09_RS01840 Protein ID WP_001223208.1
Coordinates 390359..390610 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
C5N09_RS01830 (386024) 386024..389803 + 3780 WP_000060978.1 autotransporter assembly complex protein TamB -
C5N09_RS01835 (389806) 389806..390147 + 342 WP_001219160.1 gamma-glutamylcyclotransferase -
C5N09_RS01840 (390359) 390359..390610 + 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
C5N09_RS01845 (390604) 390604..390954 + 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
C5N09_RS01850 (391034) 391034..391564 - 531 WP_000055072.1 inorganic diphosphatase -
C5N09_RS01855 (391874) 391874..392830 + 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
C5N09_RS01860 (392970) 392970..394472 + 1503 WP_000205784.1 sugar ABC transporter ATP-binding protein -
C5N09_RS01865 (394486) 394486..395508 + 1023 WP_001295197.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T223031 WP_000239579.1 NZ_CP086338:390604-390954 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T223031 NZ_CP118278:1871213-1871315 [Klebsiella quasipneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT223031 WP_001223208.1 NZ_CP086338:390359-390610 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT223031 NZ_CP118278:c1871319-1871172 [Klebsiella quasipneumoniae]
AGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTG
GCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGTCTGCG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References