Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Acetyltransf_4(toxin)
Location 1891373..1892881 Replicon chromosome
Accession NC_009656
Organism Pseudomonas aeruginosa PA7

Toxin (Protein)


Gene name - Uniprot ID A0A431X3Y4
Locus tag PSPA7_RS08850 Protein ID WP_023443179.1
Coordinates 1891373..1891960 (+) Length 196 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A6V2F0
Locus tag PSPA7_RS08855 Protein ID WP_012074952.1
Coordinates 1892027..1892881 (+) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PSPA7_RS08845 1887628..1891107 - 3480 WP_012074951.1 hybrid sensor histidine kinase/response regulator -
PSPA7_RS08850 1891373..1891960 + 588 WP_023443179.1 GNAT family N-acetyltransferase Toxin
PSPA7_RS08855 1892027..1892881 + 855 WP_012074952.1 AraC family transcriptional regulator Antitoxin
PSPA7_RS08860 1892977..1895142 + 2166 WP_003155399.1 TonB-dependent receptor family protein -
PSPA7_RS08865 1895317..1897191 + 1875 WP_012074953.1 MFS transporter -
PSPA7_RS08870 1897252..1897461 - 210 WP_003091604.1 cold-shock protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(20-152)

Antitoxin

DNA binding HTH domain, AraC-type

(196-273)


Sequences

Toxin        


Download         Length: 196 a.a.        Molecular weight: 21878.19 Da        Isoelectric Point: 9.8675

>T22300 WP_023443179.1 NC_009656:1891373-1891960 [Pseudomonas aeruginosa PA7]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQGIADQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQFSTAASNLRAQGAIDKLGAQREGLLRN
QRRLAGGRLDDTIVYSITDHEWPQVKSALEASFTG

Download         Length: 588 bp

>T22300 NC_009656:1891373-1891960 [Pseudomonas aeruginosa PA7]
ATGTCGAGGAGGGCGCCCATGTTCAAGCCGCTACCTATCACCCTGCAGCGTGGAGCCTTGCGGCTCGAGCCGCTGGTGGA
AGCGGACATTCCCGAGCTGGTGAGCCTTGCCGAAGCCAACCGCGAGGCACTGCAGTACATGGACGGACCGACGCGCCCGG
ACTGGTATCGCCAGGGCATCGCCGACCAGCGCGAGGGACGCGCGTTGCCGCTGGCGGTACGCCTGGGCGTGCAACTGGTC
GGGACCACGCGCTTCGCCGAATTCCTTCCCGCCCTGCCGGCCTGCGAGATCGGCTGGACCTGGCTCGACCAGGCCCAGCA
CGGCAGCGGCCTGAACCGCATGATCAAGTACCTGATGCTCAAGCATGCCTTCGACAACCTGCGCATGGTCCGCGTGCAGT
TCAGCACGGCGGCGAGCAACCTGCGCGCCCAGGGCGCCATCGACAAGCTCGGCGCCCAGCGCGAGGGCCTGCTGCGCAAC
CAGCGGCGCCTGGCCGGCGGGCGTCTCGACGACACCATCGTCTACAGCATCACCGACCACGAATGGCCCCAGGTCAAGTC
CGCGCTGGAAGCCAGTTTCACCGGCTGA

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31788.11 Da        Isoelectric Point: 7.7066

>AT22300 WP_012074952.1 NC_009656:1892027-1892881 [Pseudomonas aeruginosa PA7]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSGFALVFIEQGAQRFRHRGGEHLAPWGSMVLINPDEVHTGSK
AHDSGWLYRGYYPEVEQIASILDELEIRHGGVPRFADSVVHDQPLARAFVHLHRLLADHAGSLETQTCWRETLLALFRRH
ARLPEAPKAGSEPLAVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKNGRA
PLDVALELGFADQSHLGRQFKQAYGVAPGEYRAACARSSLTMCE

Download         Length: 855 bp

>AT22300 NC_009656:1892027-1892881 [Pseudomonas aeruginosa PA7]
GTGCCGGACGAGACGAGCGGAGAACATACGCATTTCTGGCGCGCCGCCGAACTGGGCGGCGTCGAGTTGCTGCATGCGCG
CTACGTCGAGCAGCGTTTCGCCCCCCATGTGCACAGCGGCTTCGCCCTGGTCTTCATCGAGCAGGGCGCGCAGCGCTTCC
GCCATCGCGGCGGCGAGCACCTGGCGCCCTGGGGCAGCATGGTGCTGATCAACCCCGACGAAGTGCACACCGGCTCCAAG
GCCCATGACTCCGGCTGGCTCTATCGCGGCTACTACCCGGAGGTGGAGCAGATCGCCAGTATCCTCGACGAGCTGGAAAT
CCGCCACGGCGGGGTGCCGCGTTTCGCCGACAGCGTGGTCCATGACCAGCCCCTGGCGCGCGCCTTCGTCCATCTGCACC
GCTTGCTGGCCGACCACGCCGGCAGCCTGGAAACCCAGACCTGCTGGCGCGAGACGCTGCTCGCCCTGTTCCGTCGCCAC
GCCCGCCTGCCGGAGGCGCCGAAGGCCGGGTCGGAACCGTTGGCGGTCGCCCGCGCCCGCGAGTTGCTGGCGGCGCGTTT
GCTCGACCCGCCGTCGCTGGAAGAACTGGCGGCTGCGGTGAATCTGTCGCCGTTCCACTTCGCCCGGGTGTTCCGCCGCG
CCACCGGGATGCCGCCGCATGCCTGGCTCCGGCAACGGCGCCTGGAACAGGCCAGGGCGCTGCTCAAGAATGGCCGGGCG
CCGCTGGATGTCGCCCTGGAACTGGGCTTCGCCGACCAGAGCCATCTCGGTCGCCAGTTCAAGCAGGCCTACGGCGTGGC
GCCGGGCGAGTACCGCGCGGCCTGTGCGCGCTCGTCCTTGACGATGTGCGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A431X3Y4

Antitoxin

Source ID Structure
AlphaFold DB A6V2F0

References