Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 213690..214195 Replicon chromosome
Accession NC_009656
Organism Pseudomonas aeruginosa PA7

Toxin (Protein)


Gene name parE Uniprot ID A0A3S0LZE8
Locus tag PSPA7_RS00960 Protein ID WP_003156094.1
Coordinates 213690..213971 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag PSPA7_RS00965 Protein ID WP_003083775.1
Coordinates 213968..214195 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PSPA7_RS00935 208949..210298 + 1350 WP_079262148.1 C4-dicarboxylate transporter DctA -
PSPA7_RS00940 210347..211033 + 687 WP_011979163.1 FadR family transcriptional regulator -
PSPA7_RS00945 211134..211868 + 735 WP_011979164.1 GntR family transcriptional regulator -
PSPA7_RS00950 212035..212436 + 402 WP_049791984.1 aegerolysin family protein -
PSPA7_RS00955 212503..213393 - 891 WP_011979166.1 LysR family transcriptional regulator -
PSPA7_RS00960 213690..213971 - 282 WP_003156094.1 type II toxin-antitoxin system toxin ParE Toxin
PSPA7_RS00965 213968..214195 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
PSPA7_RS00970 214371..214991 - 621 WP_011979168.1 hypothetical protein -
PSPA7_RS00975 215092..215592 + 501 WP_011979169.1 LEA type 2 family protein -
PSPA7_RS00980 215665..216006 + 342 WP_003101229.1 alkylphosphonate utilization protein -
PSPA7_RS00985 216126..217553 - 1428 WP_011979170.1 GABA permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10433.15 Da        Isoelectric Point: 9.6558

>T22299 WP_003156094.1 NC_009656:c213971-213690 [Pseudomonas aeruginosa PA7]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQEVANQGAGRPSEVPGVRTLALERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T22299 NC_009656:c213971-213690 [Pseudomonas aeruginosa PA7]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTATGACCACTACGTGGTGCTGATCGGCCCGGA
GAAAGCGCTGAAAGCCGTCCAGGACATCGTCGAGCAGGTGAAACCGCTACAGGAGGTGGCCAACCAGGGGGCGGGGCGAC
CCAGCGAGGTGCCAGGCGTACGCACCCTGGCGCTGGAGCGCTGGCCGTTCAGCGCCCCATTTCGGGTAAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT22299 WP_003083775.1 NC_009656:c214195-213968 [Pseudomonas aeruginosa PA7]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp

>AT22299 NC_009656:c214195-213968 [Pseudomonas aeruginosa PA7]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGATGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACACCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S0LZE8

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References