Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 638671..639197 | Replicon | chromosome |
| Accession | NZ_CP086334 | ||
| Organism | Escherichia coli strain EBJ003 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | C5N12_RS03295 | Protein ID | WP_000323025.1 |
| Coordinates | 638910..639197 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | C5N12_RS03290 | Protein ID | WP_000534858.1 |
| Coordinates | 638671..638910 (+) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| C5N12_RS03260 (633933) | 633933..634547 | + | 615 | WP_001265627.1 | hypothetical protein | - |
| C5N12_RS03265 (634550) | 634550..635572 | + | 1023 | WP_000915483.1 | DUF4868 domain-containing protein | - |
| C5N12_RS03270 (636077) | 636077..637099 | + | 1023 | Protein_639 | ISNCY family transposase | - |
| C5N12_RS03275 (637220) | 637220..637369 | + | 150 | WP_011443592.1 | protein YdfW | - |
| C5N12_RS03280 (637806) | 637806..638138 | - | 333 | WP_001301033.1 | FlxA-like family protein | - |
| C5N12_RS03285 (638341) | 638341..638646 | - | 306 | WP_001326990.1 | protein YdfV | - |
| C5N12_RS03290 (638671) | 638671..638910 | + | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| C5N12_RS03295 (638910) | 638910..639197 | + | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| C5N12_RS03300 (639269) | 639269..639424 | + | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| C5N12_RS03305 (639641) | 639641..639892 | + | 252 | WP_000980994.1 | protein Rem | - |
| C5N12_RS03310 (639959) | 639959..640237 | + | 279 | WP_012304870.1 | hypothetical protein | - |
| C5N12_RS03315 (640239) | 640239..641288 | + | 1050 | WP_001265199.1 | DUF968 domain-containing protein | - |
| C5N12_RS03320 (641302) | 641302..642054 | + | 753 | WP_001047135.1 | antitermination protein | - |
| C5N12_RS03325 (642332) | 642332..642421 | - | 90 | WP_120795389.1 | hypothetical protein | - |
| C5N12_RS03330 (642476) | 642476..642688 | - | 213 | WP_000087756.1 | cold shock-like protein CspF | - |
| C5N12_RS03335 (642989) | 642989..643204 | + | 216 | WP_000066484.1 | cold shock-like protein CspB | - |
| C5N12_RS03340 (643568) | 643568..643738 | - | 171 | WP_211180497.1 | putative zinc-binding protein YnfU | - |
| C5N12_RS03345 (643958) | 643958..644173 | + | 216 | WP_000839590.1 | phage lysis protein EssD | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 612517..674804 | 62287 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T222986 WP_000323025.1 NZ_CP086334:638910-639197 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T222986 NZ_CP118269:3663561-3663917 [Pantoea sp. Lij88]
ATGTGGACCGTGCTATTGAGCCCGCGTTTTGAAAGCTGGCTAAGTGAGCAGGAAGAAGCCCTGCAGGAAAAAATGTTAGC
GGATCTGGGAAAGTTAAAAGTATACGGCCCTGATTTGCCACGCCCTTATGCGGATACCCTTAAGGGCTCACAGTACAAGA
ATATGAAAGAACTCCGCGTACAGTTTGCAGGAAAGCCAATTCGGGCATTTTATGCTTTTGATCCTGTACGCCAGGCTATC
GTGTTATGTGCAGGCGATAAGAGTCATGACAAACGTTTTTATATCCGAATGATACGCATTGCTGACGAAGAATTTTCAGC
ATGGCTGGCTGAACAGGAAAGGAAAAATAATTCATGA
ATGTGGACCGTGCTATTGAGCCCGCGTTTTGAAAGCTGGCTAAGTGAGCAGGAAGAAGCCCTGCAGGAAAAAATGTTAGC
GGATCTGGGAAAGTTAAAAGTATACGGCCCTGATTTGCCACGCCCTTATGCGGATACCCTTAAGGGCTCACAGTACAAGA
ATATGAAAGAACTCCGCGTACAGTTTGCAGGAAAGCCAATTCGGGCATTTTATGCTTTTGATCCTGTACGCCAGGCTATC
GTGTTATGTGCAGGCGATAAGAGTCATGACAAACGTTTTTATATCCGAATGATACGCATTGCTGACGAAGAATTTTCAGC
ATGGCTGGCTGAACAGGAAAGGAAAAATAATTCATGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT222986 WP_000534858.1 NZ_CP086334:638671-638910 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT222986 NZ_CP118269:3663914-3664213 [Pantoea sp. Lij88]
ATGAGAACCCTGGATGATGTTATCGCTGGCTTCTCCCCTGAGAGTCAGGCGCGAATCAAAGAAATGTCTGATGAAATGGT
TCTGGAGGTCGGGCTTCAGATGATTCGTGAAGAGCTTCAGTTATCGCAGAAGACGCTTGCCGAGGCCATGGGGGTGCGAC
AGCCTGCTATTGCTCAGATTGAGCAACGCGGGAATGAGATTAAAGTTGCCACACTCAAACGCTATATCGAAGCAATGGGC
GGAAAACTCAGTCTTGATGTGGAGCTTCCAACCGGAAAAAGAGTGGCCTTTCACATCTAA
ATGAGAACCCTGGATGATGTTATCGCTGGCTTCTCCCCTGAGAGTCAGGCGCGAATCAAAGAAATGTCTGATGAAATGGT
TCTGGAGGTCGGGCTTCAGATGATTCGTGAAGAGCTTCAGTTATCGCAGAAGACGCTTGCCGAGGCCATGGGGGTGCGAC
AGCCTGCTATTGCTCAGATTGAGCAACGCGGGAATGAGATTAAAGTTGCCACACTCAAACGCTATATCGAAGCAATGGGC
GGAAAACTCAGTCTTGATGTGGAGCTTCCAACCGGAAAAAGAGTGGCCTTTCACATCTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|