Detailed information of TA system TA222975

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PumAB/COG3657-dnstrm_HI1420
• Location: 3514705..3515297
• Replicon: chromosome
• Accession: NZ_CP086333
• Organism: Xanthomonas translucens pv. arrhenatheri strain LMG 727

Toxin (Protein)

• Gene name: PumA
• Uniprot ID: A0A0K2ZF26
• Locus tag: KM317_RS14470
• Protein ID: WP_053833736.1
• Coordinates: 3514705..3515001 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: PumB
• Uniprot ID: -
• Locus tag: KM317_RS14475
• Protein ID: WP_009580422.1
• Coordinates: 3515004..3515297 (+)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KM317_RS14455 (KM317_14455)	3510057..3511220	-	1164	WP_053833739.1	ADP-forming succinate--CoA ligase subunit beta	-
KM317_RS14460 (KM317_14460)	3511464..3513077	+	1614	WP_053833738.1	HAMP domain-containing sensor histidine kinase	-
KM317_RS14465 (KM317_14465)	3513152..3514540	+	1389	WP_053833737.1	sigma-54 dependent transcriptional regulator	-
KM317_RS14470 (KM317_14470)	3514705..3515001	+	297	WP_053833736.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KM317_RS14475 (KM317_14475)	3515004..3515297	+	294	WP_009580422.1	putative addiction module antidote protein	Antitoxin
KM317_RS14480 (KM317_14480)	3515325..3517061	-	1737	WP_053833735.1	type IV-A pilus assembly ATPase PilB	-
KM317_RS14485 (KM317_14485)	3517249..3517692	+	444	WP_186008602.1	hypothetical protein	-
KM317_RS14490 (KM317_14490)	3517848..3518273	-	426	WP_053833734.1	pilin	-
KM317_RS14495 (KM317_14495)	3518654..3519913	+	1260	WP_053833733.1	type II secretion system F family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (39-91)

Antitoxin

• Uncharacterized protein HI1420 (5-92)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11167.76 Da
• Isoelectric Point: 10.3355

>T222975 WP_053833736.1 NZ_CP086333:3514705-3515001 [Xanthomonas translucens pv. arrhenatheri]
VIELKQTETFRKWRTKLKDERARTAIALRLTRLAYGHAGDTEAVGQGISELRIHHGPGYRVYFQRRGDTIIVLLCGGDKS
TQAKDIKTAKRLADEWSE

Nucleotide

• Length: 297 bp

>T222975 NZ_CP118233:3242782-3243201 [Micromonospora chalcea]
ATGACGCGGGAGCGCTACCTTCTCGACAAGTCGGCGCTCGCCAGGTGGCCGAAGCCCGCCGTGGCACCCGTCCTGGACGA
GTTGTCCGAGCGCGGTCTGCTGGCGGTCTGCGGGGCGGTCGAGATCGAGGTGGTGCACAGCGCCCGCTCGGCCAAGGACG
CGCAGCGCGCTCGATGGCTGCTTCGCGGCTTCGACTGGCTCGCCATGCCGGACGACATCTGGGATCGTGCGATCGACGTC
CAGGTGCAGGCGCTGCACAAGGGCAACCACCGCGCGCTTTCGATGGCCGATCTGCTGATCGCCGCCACCGCCGAACGGCA
TGGCGTGACCGTTCTGCACTACGACGGTGACTTCGACCTGATCACCGCGATCACCGGCCAGCCGACGACGTGGGTCGTCC
CGGCCGGAAAGGCCGACTGA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 10376.69 Da
• Isoelectric Point: 4.9890

>AT222975 WP_009580422.1 NZ_CP086333:3515004-3515297 [Xanthomonas translucens pv. arrhenatheri]
MTENLTTYDPAEDLNSDQAIADFMAGAFATNDTGFIAHALGIVARAKGMTQIARQTGLSREQLYRSFSEDGNPTLRTTLA
VMKALGIELTAKAAVTH

Nucleotide

• Length: 294 bp

>AT222975 NZ_CP118233:3242576-3242785 [Micromonospora chalcea]
GTGTCCCGGACCATCCTTGACGTCGACGACGACCTCCTGGCCGAGGCCGCCGAGATCCTCGGTACCGGCACCAAGAAGGC
CACCGTCAACGCCGCGCTGCAGGAAGTGGTCAACCGGGAGAAGCGCCGGGAGTTCGCCGACTGGCTCAAGAGCGGCGGCC
TGCCGGACCTCACCGACCCGCAGCAGGCGTCGAAGCCCGAAGCGGCATGA

Structures

Toxin

• AlphaFold DB: A0A0K2ZF26