Detailed information of TA system TA222974

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/Phd(antitoxin)
• Location: 1676616..1677181
• Replicon: chromosome
• Accession: NZ_CP086333
• Organism: Xanthomonas translucens pv. arrhenatheri strain LMG 727

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: KM317_RS07045
• Protein ID: WP_081004829.1
• Coordinates: 1676616..1676936 (-)
• Length: 107 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A0K2ZGI9
• Locus tag: KM317_RS07050
• Protein ID: WP_053834608.1
• Coordinates: 1676924..1677181 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KM317_RS07030 (KM317_07030)	1671714..1672184	+	471	WP_009598449.1	GFA family protein	-
KM317_RS07035 (KM317_07035)	1672522..1673268	+	747	WP_003467227.1	23S rRNA (guanosine(2251)-2'-O)-methyltransferase RlmB	-
KM317_RS07040 (KM317_07040)	1673607..1676606	+	3000	WP_081004828.1	ligand-binding sensor domain-containing diguanylate cyclase	-
KM317_RS07045 (KM317_07045)	1676616..1676936	-	321	WP_081004829.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KM317_RS07050 (KM317_07050)	1676924..1677181	-	258	WP_053834608.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
KM317_RS07055 (KM317_07055)	1677290..1677916	-	627	WP_144423735.1	hypothetical protein	-
KM317_RS07060 (KM317_07060)	1678218..1678862	-	645	WP_053834609.1	ribonuclease T	-
KM317_RS07065 (KM317_07065)	1679167..1679913	-	747	WP_053834610.1	putative DNA-binding domain-containing protein	-
KM317_RS07070 (KM317_07070)	1679906..1680781	-	876	WP_053834611.1	DUF692 domain-containing protein	-
KM317_RS07075 (KM317_07075)	1680768..1681130	-	363	WP_053834612.1	hypothetical protein	-
KM317_RS07080 (KM317_07080)	1681344..1682054	-	711	WP_003467248.1	phosphate signaling complex protein PhoU	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-87)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-67)

Sequences

Toxin

Protein

• Length: 107 a.a.
• Molecular weight: 11994.63 Da
• Isoelectric Point: 7.3592

>T222974 WP_081004829.1 NZ_CP086333:c1676936-1676616 [Xanthomonas translucens pv. arrhenatheri]
MAEIVWPEPALTDLDAIADYIALESPVAASELVKRRFDHVEQPGEHPASGSRPQELGRSRYRQRVEPPCRVFYRHDGHTV
FMLQVMRSEGLLREGRLASRAGQAKV

Nucleotide

• Length: 321 bp

>T222974 NZ_CP118227:c3924637-3924260 [Proteus mirabilis]
ATGAATACATTACCCGACACTCACGTACGGGAGGCATCGGGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCATCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGGAA
CAATTACAGAATGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCAAAACGATGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9659.17 Da
• Isoelectric Point: 8.7288

>AT222974 WP_053834608.1 NZ_CP086333:c1677181-1676924 [Xanthomonas translucens pv. arrhenatheri]
MRTELVTPLKRQATELLADIERDRQPILITQHGLPSAYLVDVETHELMQQRMAVLEGIARGEQAVAEGRVATQAEARKRL
GRWLK

Nucleotide

• Length: 258 bp

>AT222974 NZ_CP118227:c3925061-3924684 [Proteus mirabilis]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCATACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCATCACACTGTATGCGAAGGGGCTGACCTGCGAAGCCGATACCCTTGGCAGTTG
TGGTTACGCTTATCTGGCTGTTTATCCGACACCGGCAGAGCCCGCAATCACCGTATAA

Structures

Antitoxin

• AlphaFold DB: A0A0K2ZGI9