Detailed information of TA system TA222973

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-yefM/YoeB-YefM
• Location: 1086300..1086757
• Replicon: chromosome
• Accession: NZ_CP086333
• Organism: Xanthomonas translucens pv. arrhenatheri strain LMG 727

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A0K3A4N2
• Locus tag: KM317_RS04630
• Protein ID: WP_053836343.1
• Coordinates: 1086300..1086557 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: A0A0K3A041
• Locus tag: KM317_RS04635
• Protein ID: WP_064521552.1
• Coordinates: 1086554..1086757 (-)
• Length: 68 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KM317_RS04600 (KM317_04600)	1081884..1082846	+	963	WP_053836347.1	DNA polymerase III subunit delta'	-
KM317_RS04605 (KM317_04605)	1082843..1083196	+	354	WP_003479797.1	PilZ domain-containing protein	-
KM317_RS04615 (KM317_04615)	1083755..1084048	-	294	WP_144423872.1	hypothetical protein	-
KM317_RS04620 (KM317_04620)	1084045..1084548	-	504	WP_053836346.1	hypothetical protein	-
KM317_RS04625 (KM317_04625)	1084957..1085331	-	375	Protein_910	ankyrin repeat domain-containing protein	-
KM317_RS20255	1085522..1085653	-	132	WP_260676289.1	hypothetical protein	-
KM317_RS04630 (KM317_04630)	1086300..1086557	-	258	WP_053836343.1	Txe/YoeB family addiction module toxin	Toxin
KM317_RS04635 (KM317_04635)	1086554..1086757	-	204	WP_064521552.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
KM317_RS04640 (KM317_04640)	1086856..1087991	+	1136	WP_155742827.1	IS3 family transposase	-
KM317_RS04645 (KM317_04645)	1088031..1088648	-	618	WP_053836526.1	HAD-IA family hydrolase	-
KM317_RS04650 (KM317_04650)	1089022..1090596	+	1575	WP_144423895.1	flavin monoamine oxidase family protein	-
KM317_RS04655 (KM317_04655)	1090593..1091009	+	417	WP_053836510.1	cytochrome c	-
KM317_RS04660 (KM317_04660)	1091056..1091565	+	510	WP_053836511.1	RidA family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (2-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-58)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 10078.55 Da
• Isoelectric Point: 8.8346

>T222973 WP_053836343.1 NZ_CP086333:c1086557-1086300 [Xanthomonas translucens pv. arrhenatheri]
VTVQFSDNAWEDYLYWQQTDKKMLKRINDLIKAIQCDPFQGVGKPEPLRHALAGYWSRRINDEHRIVYKVEAGVLLIAQV
RYHYA

Nucleotide

• Length: 258 bp

>T222973 NZ_CP118227:c3764655-3764236 [Proteus mirabilis]
GTGAAAAAAGTCTATATGCTTGATACAAACATTTGTTCTTTTATCATGCGTGAGCAACCTATTTCTTTGCTCGAAAAACT
TCAGAAATGTGTAATGAACCACGATACTATTGTCATATCAGCGATTACTTATTCAGAGATGCGCTTTGGAGCAATAGGAA
AAAAAGCATCACCTAAACACAATCGTTTGGTTGATGCTTTCTGTGAACGCGTTGACGCGATTTTGGCATGGGATAAAGCG
GCGGTAGACGCAACTACCGTGATAAAAAAATGCTTATCTGATGTGGGATTGCCCATAGGAAATAATGATAGCGCGATTGC
TGGTCATGCTGTCGCGGTTAATGCAATATTGGTAACAAATAATACCCGTGAATTTTCACGAGTTGAAGGACTAAAAATAG
AGGACTGGACTCATGTTTGA

Antitoxin

Protein

• Length: 68 a.a.
• Molecular weight: 7628.72 Da
• Isoelectric Point: 5.8255

>AT222973 WP_064521552.1 NZ_CP086333:c1086757-1086554 [Xanthomonas translucens pv. arrhenatheri]
MERVVNNHEPVIITRSREQSVVMLSLEDYKAMEETAYLLRSPKSAQRLLESIAQLEAGRGKARDLAE

Nucleotide

• Length: 204 bp

>AT222973 NZ_CP118227:c3764885-3764652 [Proteus mirabilis]
ATGAGAACGAGAACTGTAGCTGTATTTAAAAACGGAAGTAACCGAGCCATTCGCTTACCTAAAGATTTCGATTTTGATGG
TGTCAATGAACTCGAGATAAGCCGAGATGGGGATTGTATTATTTTACGCCCTGTAAAACCTAACTGGATTTCATTACAAA
ACGAAGAAAAAGCCGATAGTGATTTCTTGCTTGAACGCGATGATGTTATTGAAGAAGGACGAGTTATTCTGTGA

Structures

Toxin

• AlphaFold DB: A0A0K3A4N2

Antitoxin

• AlphaFold DB: A0A0K3A041