Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 2245293..2247058 Replicon chromosome
Accession NZ_CP086305
Organism Burkholderia ambifaria strain B21-004

Toxin (Protein)


Gene name doc Uniprot ID B1FDH3
Locus tag LMA00_RS26410 Protein ID WP_006751279.1
Coordinates 2246147..2247058 (-) Length 304 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID B1FDH2
Locus tag LMA00_RS26405 Protein ID WP_006751278.1
Coordinates 2245293..2246150 (-) Length 286 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LMA00_RS26385 (LMA00_26400) 2240422..2241912 - 1491 WP_228891259.1 aldehyde dehydrogenase -
LMA00_RS26390 (LMA00_26405) 2242019..2242846 - 828 WP_006751275.1 aspartate dehydrogenase -
LMA00_RS26395 (LMA00_26410) 2242839..2244506 - 1668 WP_228891261.1 thiamine pyrophosphate-binding protein -
LMA00_RS26400 (LMA00_26415) 2244499..2245296 - 798 WP_175671271.1 SDR family oxidoreductase -
LMA00_RS26405 (LMA00_26420) 2245293..2246150 - 858 WP_006751278.1 IclR family transcriptional regulator Antitoxin
LMA00_RS26410 (LMA00_26425) 2246147..2247058 - 912 WP_006751279.1 alpha/beta fold hydrolase Toxin
LMA00_RS26415 (LMA00_26430) 2247078..2247605 - 528 WP_228891263.1 cupin domain-containing protein -
LMA00_RS26420 (LMA00_26435) 2247645..2248415 - 771 WP_228891265.1 SDR family oxidoreductase -
LMA00_RS26425 (LMA00_26440) 2248408..2249478 - 1071 WP_006751282.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
LMA00_RS26430 (LMA00_26445) 2249533..2249844 - 312 WP_006751283.1 hypothetical protein -
LMA00_RS26435 (LMA00_26450) 2249846..2250163 - 318 WP_006751284.1 non-heme iron oxygenase ferredoxin subunit -
LMA00_RS26440 (LMA00_26455) 2250614..2251693 + 1080 WP_105787041.1 porin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(56-284)

Antitoxin

Transcription regulator IclR, C-terminal

(144-266)


Sequences

Toxin        


Download         Length: 304 a.a.        Molecular weight: 31244.50 Da        Isoelectric Point: 6.8173

>T222959 WP_006751279.1 NZ_CP086305:c2247058-2246147 [Burkholderia ambifaria]
MSVIDKRERDRTAAFAALLGQFPEQRCAAGAAGTIGYREAGAGEAGAQHAGHALPVVLLHGIGSGAASWVCQLDTLGASR
RVLAWDAPGYGVSTPVHGASPTAADYAASLNAWLEALGIERCVLVGHSLGAIIAGGLCRLMPARIAGLLLISPAGGYGRA
PAETRDTRRDARLALLEELGPAGLAEQRSGNMLSGFASEDARAWVRWNMARIVPAGYAQATHLLANADLATDLAGFRGRT
AVAVGANDAITPPAACERIAAAAQVELQVIPQAGHAGYVEAPAVYSSLIDTFCRQCDTQRGMA

Download         Length: 912 bp

>T222959 NZ_CP118223:759961-760449 [Klebsiella grimontii]
ATGATTTCCGCCCCTGAGCCGCTTCATGCCGGACATATTCTTACCCCGTTTTGCTGCGGCGTGGATTCTATGGATAACTG
GCTGAAACAGCGGGCGATGAAGAACCAGCTTTCCGGCGCGTCCCGTACATTTGTCTGCTGCGACGATGCTAAGGTGATGG
CTTACTACTCGCTGGCTTCAAGCGCAGTGGCGACAAATACTGCGCCCGGTCACTTCCGCCGCAATATGCCTGACCCGATC
CCAGTTGTGGTGCTGGGTCGTCTGGCGGTGGATAAATCGCTGCATGGGAAGGGCCTAGGGCGGGCGCTGATAAGGGATGC
CGGACTGCGGGTCATTCAGGTGGCGGAAACTATCGGTATTCGCGGGATGTTGGTTCATGCGCTGTCAGATGAAGCGCGGG
AGTTTTACCTGCGGGTGGGATTTGAACCATCGCCGATGGATCCGATGATGCTGATGGTAACGCTGGGGGATTTGGTGGGT
AGTGTTTGA

Antitoxin


Download         Length: 286 a.a.        Molecular weight: 31399.93 Da        Isoelectric Point: 6.3579

>AT222959 WP_006751278.1 NZ_CP086305:c2246150-2245293 [Burkholderia ambifaria]
MSEPLQQPESESTKADAGYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYK
LGIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQCQSPVFSAIRVNVGTRLPAHATTHGH
VLMGDLSLKELRALYPEGTLSRMTSATPETVDALYEVIREDALRGYGISNSSFERGISVVTAPVRNDTQKIVACITVTVP
RPEIDEALIADGLFDKVQRAAAELSRRLNYRSDDEHTFLKALGLR

Download         Length: 858 bp

>AT222959 NZ_CP118223:759671-759964 [Klebsiella grimontii]
ATGCCAGCCGCAAACAGTATGGCGATGAAACGCGAAACCCTGAACCTGCGCATCAAACCCGCCGAGCGCGATCTTATCGA
TCGGGCGGCGAAAGCCAGAGGGAAAAACCGCACTGACTTTGTGCTGGAGGCCGCCCGCGCCGCAGCGGAAGAGGCGCTGA
TCGAGCAGCGCATCATTATGGCCGATCCGCAGGCTTATCAGGAATTTCTGGCTCGTCTGGATCAGGCTCCGGCACCTAAT
GCCGCACTGCGTAAAACTATGCAGACCCCTGCGCCGTGGGAACAGGAAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B1FDH3

Antitoxin

Source ID Structure
AlphaFold DB A0A2S9KT53

References