Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 1990569..1991208 Replicon chromosome
Accession NZ_CP086305
Organism Burkholderia ambifaria strain B21-004

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LMA00_RS25305 Protein ID WP_175763812.1
Coordinates 1990569..1990985 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LMA00_RS25310 Protein ID WP_228891104.1
Coordinates 1990972..1991208 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LMA00_RS25280 (LMA00_25295) 1985710..1986816 - 1107 WP_228891096.1 nitronate monooxygenase -
LMA00_RS25285 (LMA00_25300) 1986813..1987739 - 927 WP_228891098.1 enoyl-CoA hydratase -
LMA00_RS25290 (LMA00_25305) 1987748..1988545 - 798 WP_228891100.1 ketoacid CoA transferase -
LMA00_RS25295 (LMA00_25310) 1988556..1989449 - 894 WP_228891102.1 CoA-transferase -
LMA00_RS25300 (LMA00_25315) 1989459..1990355 - 897 WP_175794967.1 VOC family protein -
LMA00_RS25305 (LMA00_25320) 1990569..1990985 - 417 WP_175763812.1 type II toxin-antitoxin system VapC family toxin Toxin
LMA00_RS25310 (LMA00_25325) 1990972..1991208 - 237 WP_228891104.1 DNA-binding protein Antitoxin
LMA00_RS25315 (LMA00_25330) 1991427..1991822 - 396 WP_228891106.1 hypothetical protein -
LMA00_RS25320 (LMA00_25335) 1991972..1993198 + 1227 WP_228891108.1 acyltransferase -
LMA00_RS25325 (LMA00_25340) 1993264..1994037 - 774 WP_228891110.1 SDR family oxidoreductase -
LMA00_RS25330 (LMA00_25345) 1994075..1995655 - 1581 WP_228891112.1 FadD3 family acyl-CoA ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-130)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15265.46 Da        Isoelectric Point: 6.9900

>T222958 WP_175763812.1 NZ_CP086305:c1990985-1990569 [Burkholderia ambifaria]
VFLIDTNVISEIRKGKRTNRGVRAFFRQAEADASPLYLSVVTVAELRRGVDLIRHRGDHPQASALEAWMATILSGYASNI
LPVDIEAAQMWGHLRVPDPAHALDHLIAATALINDLTVVTRNVDDFARTGVRLLNPFD

Download         Length: 417 bp

>T222958 NZ_CP118223:42968-43309 [Klebsiella grimontii]
ATGTGGGATGTTGAAACAACGGAGGTTTTCGACAAGTGGTTTGAGGCGCAGATCGAAGCGCTTAAAGAGGATATGCTCGC
CGCTATGGTGATCTTATCCGAGTATGGCCCCCAACTCGGAAGGCCGTTTGCGGATACAGTAAACGATTCTGCTTTTTCGA
ATATGAAAGAGCTGCGCGTTCAGCATCGAGGTAGCCCGATCAGAGCTTTCTTTGTATTTGACCCTTCTCGTCGCGGCATC
GTGTTATGCGCCGGAGATAAAACAGGGTTAAATGAAAAGAGATTCTATAAAGATATGATCAAGCTTGCAGATGCTGAGTA
CCGTAAGCACCTTAATCAGTAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8710.78 Da        Isoelectric Point: 5.0774

>AT222958 WP_228891104.1 NZ_CP086305:c1991208-1990972 [Burkholderia ambifaria]
MANLLVRNVDDSIVQSLREQAVANGRSAEAEHRAILAEALGRPKRRTFAQVLMSMPDVGEDADFQRVQDSGEVRRVFD

Download         Length: 237 bp

>AT222958 NZ_CP118223:43319-43618 [Klebsiella grimontii]
ATGGCGACCCTTAAAGAATTAATGGCCAAACAGAGCCCGGAAAGCCAGGCGCGTATTGCTGAAAAAGTCGAAGAAATGCG
CCAGGCTATCGCATTAAGTATGTTAAGGGAAGAACTCAATATGTCTCAGGCAGAGCTGGCTAAGGCAATGGGCGTTAAAC
AACCCACCATTGCAAAAATGGAACAGGCTGATAACGACCCGCGTTTGTCAACGCTGAAGCGTTATGTTGTAGCGCTCGGG
GGGGAACTCAGTATTGATGTTAAGCTGCCAACCGGTAAGCGAATCGCATTCCATCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References