Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-PumB/upstrm_HI1419-dnstrm_HI1420
Location 1086979..1087620 Replicon chromosome
Accession NZ_CP086305
Organism Burkholderia ambifaria strain B21-004

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag LMA00_RS21235 Protein ID WP_228891817.1
Coordinates 1087282..1087620 (-) Length 113 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag LMA00_RS21230 Protein ID WP_006750245.1
Coordinates 1086979..1087278 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LMA00_RS21205 (LMA00_21215) 1082130..1083401 + 1272 WP_175793790.1 anthranilate 1,2-dioxygenase large subunit AndAc -
LMA00_RS21210 (LMA00_21220) 1083416..1083904 + 489 WP_006750249.1 anthranilate 1,2-dioxygenase small subunit AndAd -
LMA00_RS21215 (LMA00_21225) 1083931..1084257 + 327 WP_006750248.1 anthranilate 1,2-dioxygenase ferredoxin subunit AndAb -
LMA00_RS21220 (LMA00_21230) 1084247..1085468 + 1222 Protein_978 FAD-dependent oxidoreductase -
LMA00_RS21225 (LMA00_21235) 1085650..1086936 + 1287 WP_228891816.1 DUF445 domain-containing protein -
LMA00_RS21230 (LMA00_21240) 1086979..1087278 - 300 WP_006750245.1 putative addiction module antidote protein Antitoxin
LMA00_RS21235 (LMA00_21245) 1087282..1087620 - 339 WP_228891817.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LMA00_RS21240 (LMA00_21250) 1087924..1089564 + 1641 WP_105786651.1 acetolactate synthase large subunit -
LMA00_RS21245 (LMA00_21255) 1089593..1091026 + 1434 WP_228891818.1 aldehyde dehydrogenase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(16-109)

Antitoxin

Uncharacterized protein HI1420

(5-93)


Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 12658.58 Da        Isoelectric Point: 9.9413

>T222957 WP_228891817.1 NZ_CP086305:c1087620-1087282 [Burkholderia ambifaria]
MVDMLRSMPYSAPTFSIRTTDVFDAWFAGLQDRVAKRRIQARIDRLSMGNPGDWKSAGSPVVEMRVDHGPGYRVYYVRRG
TIWVILLCGGDKSTQQADIRAAHAMLARLDLE

Download         Length: 339 bp

>T222957 NZ_CP118187:c13523-13254 [Entomospira culicis]
ATGACTTACACGCTACATTATACGACTGTCGCGATCAAGGCGTTAAAAAAACTTGATCGTCCCAGCCAAATCTTGATCAT
GAATTGGATCGAGAAGCATTTGATCGATTGCGAAGATCCTCGCAGTAAGGGCAAAGCGTTGAAGGCGAATTTATCGGGGG
CATGGCGGTATCGTATCGGTGATTACCGTATTATCGCTGAGATCGATGATAGCACGGTTACAATTTTGTTGTTGGCGATT
GGGCACCGAAAAGCCATCTATAATAAATAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10674.11 Da        Isoelectric Point: 6.6384

>AT222957 WP_006750245.1 NZ_CP086305:c1087278-1086979 [Burkholderia ambifaria]
MDKIKTRPWDSAEHLKTDDDMADYFEACLQEAGDDPAFIAHALGVIARARGMSQVARDAGLSREGLYKALSHDGNPSFGT
ILKVIKALGLQLHGAKAHA

Download         Length: 300 bp

>AT222957 NZ_CP118187:c13744-13523 [Entomospira culicis]
ATGACGATATCGATCCGTTTTAACGATGAAGAAGCCGAATTAATCAAACAATACGCTAAGCACAAAAAAACCACCGTATC
ACAAGTGATGCGAGAGAGCATCCTAGCCGAACTAGAAGATGAGTATGACATTGATGCCTACCAACAAGCGATGCAAGCCT
ACAAAGAGCATCCTATTACGCATAACCATGACGAAGTCAAAAAGCTATTGGATTTAGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References