Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vagCD/VapC-VagC |
| Location | 1754441..1755126 | Replicon | chromosome |
| Accession | NZ_CP086304 | ||
| Organism | Burkholderia ambifaria strain B21-004 | ||
Toxin (Protein)
| Gene name | vagD | Uniprot ID | - |
| Locus tag | LMA00_RS08350 | Protein ID | WP_228888171.1 |
| Coordinates | 1754704..1755126 (+) | Length | 141 a.a. |
Antitoxin (Protein)
| Gene name | vagC | Uniprot ID | B1FPD1 |
| Locus tag | LMA00_RS08345 | Protein ID | WP_006755051.1 |
| Coordinates | 1754441..1754707 (+) | Length | 89 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LMA00_RS08330 (LMA00_08335) | 1749971..1752220 | + | 2250 | WP_228888168.1 | TonB-dependent siderophore receptor | - |
| LMA00_RS08335 (LMA00_08340) | 1752307..1753146 | + | 840 | WP_105789037.1 | formyltransferase family protein | - |
| LMA00_RS08340 (LMA00_08345) | 1753146..1754162 | + | 1017 | WP_175762522.1 | GNAT family N-acetyltransferase | - |
| LMA00_RS08345 (LMA00_08350) | 1754441..1754707 | + | 267 | WP_006755051.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
| LMA00_RS08350 (LMA00_08355) | 1754704..1755126 | + | 423 | WP_228888171.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| LMA00_RS08355 (LMA00_08360) | 1755169..1756074 | - | 906 | WP_228888174.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | - |
| LMA00_RS08360 (LMA00_08365) | 1756043..1757134 | - | 1092 | WP_267479003.1 | type IV toxin-antitoxin system AbiEi family antitoxin | - |
| LMA00_RS08365 (LMA00_08370) | 1757469..1758632 | + | 1164 | WP_175762520.1 | M20 aminoacylase family protein | - |
| LMA00_RS08370 (LMA00_08375) | 1758663..1759988 | - | 1326 | WP_228888178.1 | cobyrinate a,c-diamide synthase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 141 a.a. Molecular weight: 14770.87 Da Isoelectric Point: 7.8895
>T222955 WP_228888171.1 NZ_CP086304:1754704-1755126 [Burkholderia ambifaria]
VTTLYMLDTNICSFIMRERPSAVLSRLQSCVNAQHRIVVSAITYAEMRFGAVGRKASPKHAELVTAFVSRLDGVLSWDTA
AVDATAAIRVDLPARGTPIGANDASIAGHAIAAGAVLVTNNSREFSRVAGLSLEDWAASA
VTTLYMLDTNICSFIMRERPSAVLSRLQSCVNAQHRIVVSAITYAEMRFGAVGRKASPKHAELVTAFVSRLDGVLSWDTA
AVDATAAIRVDLPARGTPIGANDASIAGHAIAAGAVLVTNNSREFSRVAGLSLEDWAASA
Download Length: 423 bp
>T222955 NZ_CP118167:2234716-2234832 [Bacillus subtilis]
ATGACTGTTTACGAATCATTAATGATAATGATCAATTTTGGCGGATTGATATTAAATACCGTCTTGTTGATCTTCAATAT
AATGATGATTGTAACGTCAAGCCAAAAGAAAAAATAG
ATGACTGTTTACGAATCATTAATGATAATGATCAATTTTGGCGGATTGATATTAAATACCGTCTTGTTGATCTTCAATAT
AATGATGATTGTAACGTCAAGCCAAAAGAAAAAATAG
Antitoxin
Download Length: 89 a.a. Molecular weight: 10130.41 Da Isoelectric Point: 4.6952
>AT222955 WP_006755051.1 NZ_CP086304:1754441-1754707 [Burkholderia ambifaria]
MRTVSIFKNARNQAIRIPKDMEFEGVTELEIRREGDTLLLRPVRPTWLSFASEPRADADFLLERPTVVEPGRFDLPSADD
DARTESNR
MRTVSIFKNARNQAIRIPKDMEFEGVTELEIRREGDTLLLRPVRPTWLSFASEPRADADFLLERPTVVEPGRFDLPSADD
DARTESNR
Download Length: 267 bp
>AT222955 NZ_CP118167:c2234979-2234824 [Bacillus subtilis]
ATTTCTTTAATGAGAAATGCATAAAATAAAAAGACCAGGGTGTTGGCGCACCCCGGCTCTGTACAAAAAGCTGCCCGTCA
AAGGGCTTACTCGATGTTCAATCTGCGTAGACCTAACCCTTTAAGGTTCCTAAGCTCAAGGGAAGGTCTATTTTTT
ATTTCTTTAATGAGAAATGCATAAAATAAAAAGACCAGGGTGTTGGCGCACCCCGGCTCTGTACAAAAAGCTGCCCGTCA
AAGGGCTTACTCGATGTTCAATCTGCGTAGACCTAACCCTTTAAGGTTCCTAAGCTCAAGGGAAGGTCTATTTTTT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|