Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 2313828..2315075 Replicon chromosome
Accession NZ_CP086302
Organism Burkholderia sp. B21-005

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LMA02_RS26910 Protein ID WP_228908215.1
Coordinates 2314494..2315075 (+) Length 194 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LMA02_RS26905 Protein ID WP_126225865.1
Coordinates 2313828..2314385 (+) Length 186 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LMA02_RS26880 (LMA02_26895) 2309712..2310347 + 636 WP_228908210.1 isochorismatase family cysteine hydrolase -
LMA02_RS26885 (LMA02_26900) 2310427..2311158 - 732 WP_228908211.1 ribonuclease T2 -
LMA02_RS26890 (LMA02_26905) 2311340..2312743 - 1404 WP_228908212.1 DUF308 domain-containing protein -
LMA02_RS26895 (LMA02_26910) 2312856..2313104 - 249 WP_228908213.1 hypothetical protein -
LMA02_RS26900 (LMA02_26915) 2313108..2313755 + 648 WP_228908214.1 hypothetical protein -
LMA02_RS26905 (LMA02_26920) 2313828..2314385 + 558 WP_126225865.1 helix-turn-helix transcriptional regulator Antitoxin
LMA02_RS26910 (LMA02_26925) 2314494..2315075 + 582 WP_228908215.1 HD domain-containing protein Toxin
LMA02_RS26915 (LMA02_26930) 2315117..2315845 + 729 WP_228908216.1 class I SAM-dependent methyltransferase -
LMA02_RS26920 (LMA02_26935) 2316141..2316893 + 753 WP_228908217.1 DUF3658 domain-containing protein -
LMA02_RS26925 (LMA02_26940) 2316941..2318479 - 1539 WP_228908218.1 MFS transporter -
LMA02_RS26930 (LMA02_26945) 2318657..2319562 + 906 WP_228908219.1 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-168)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-64)


Sequences

Toxin        


Download         Length: 194 a.a.        Molecular weight: 21357.92 Da        Isoelectric Point: 4.8417

>T222953 WP_228908215.1 NZ_CP086302:2314494-2315075 [Burkholderia sp. B21-005]
MNLDTIHARLDFLRAAERLKDVLRSGHTSTGRPESTAEHSWRLCLMALVFADALPDVDTTKLLKLCVVHDLGEALHGDIP
AIEQAAHPDKSTRERDDLLTLTAGLDRALRDEIVALWDEYEAAESPEARAAKALDKLETILQHNQGSNPPDFDYAFNLGY
GRRYTDATPLFGAIRAIVDADTQRRIDARGDGA

Download         Length: 582 bp

>T222953 NZ_CP118167:c2187053-2186877 [Bacillus subtilis]
GTGCTTGAGAAAGTGGGTATCGTAGTTGCTTTCCTCATATCTTTAACGGTTCTTACAATCAACAGTCTAACAATAGTTGA
GAAGGTAAGAAACCTAAAGAATGGGACAAGCAAAAAGAAAAAGCGTATACGCAAGCGGCTCCGACCAAAGAGACAACGCC
AACGTATACGCAGATAA

Antitoxin


Download         Length: 186 a.a.        Molecular weight: 20256.23 Da        Isoelectric Point: 11.0874

>AT222953 WP_126225865.1 NZ_CP086302:2313828-2314385 [Burkholderia sp. B21-005]
MTTSPLHTPPLGPQLKRWRTLRRVKQSHAAELFGVAQSTISRWEAGIQQMSPDERATAERLLAARLDSAGDHALARLIAS
STARMHLVCDLTHRLLACSPSRAAEFSRPLPALLGTSLWRYASPEIVRMEAALDPLGWHDRAGPPSVEFATGTNASRVVP
IRGSTCRWTRMTLSDGSAARLVETL

Download         Length: 558 bp

>AT222953 NZ_CP118167:2186840-2186936 [Bacillus subtilis]
TAGGAACTAAAGGAGAAGTTCATTCCCCTTTAGCGTGTTATCTGCGTATACGTTGGCGTTGTCTCTTTGGTCGGAGCCGC
TTGCGTATACGCTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References