Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 1972407..1974157 Replicon chromosome
Accession NZ_CP086302
Organism Burkholderia sp. B21-005

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag LMA02_RS25285 Protein ID WP_228907975.1
Coordinates 1973261..1974157 (-) Length 299 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag LMA02_RS25280 Protein ID WP_228907974.1
Coordinates 1972407..1973264 (-) Length 286 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LMA02_RS25260 (LMA02_25275) 1967536..1969026 - 1491 WP_228907972.1 aldehyde dehydrogenase -
LMA02_RS25265 (LMA02_25280) 1969133..1969960 - 828 WP_006758069.1 aspartate dehydrogenase -
LMA02_RS25270 (LMA02_25285) 1969953..1971620 - 1668 WP_166723280.1 thiamine pyrophosphate-binding protein -
LMA02_RS25275 (LMA02_25290) 1971613..1972410 - 798 WP_228907973.1 SDR family oxidoreductase -
LMA02_RS25280 (LMA02_25295) 1972407..1973264 - 858 WP_228907974.1 IclR family transcriptional regulator Antitoxin
LMA02_RS25285 (LMA02_25300) 1973261..1974157 - 897 WP_228907975.1 alpha/beta fold hydrolase Toxin
LMA02_RS25290 (LMA02_25305) 1974177..1974704 - 528 WP_006751280.1 cupin domain-containing protein -
LMA02_RS25295 (LMA02_25310) 1974749..1975519 - 771 WP_228907976.1 SDR family oxidoreductase -
LMA02_RS25300 (LMA02_25315) 1975512..1976582 - 1071 WP_011659097.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
LMA02_RS25305 (LMA02_25320) 1976637..1976948 - 312 WP_006758061.1 hypothetical protein -
LMA02_RS25310 (LMA02_25325) 1976950..1977267 - 318 WP_006751284.1 non-heme iron oxygenase ferredoxin subunit -
LMA02_RS25315 (LMA02_25330) 1977716..1978795 + 1080 WP_228907977.1 porin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(51-279)

Antitoxin

Transcription regulator IclR, C-terminal

(144-266)


Sequences

Toxin        


Download         Length: 299 a.a.        Molecular weight: 30773.04 Da        Isoelectric Point: 7.3667

>T222951 WP_228907975.1 NZ_CP086302:c1974157-1973261 [Burkholderia sp. B21-005]
MSVIDKRERDRTAAFAALLGQFPEQRCAAGAAGTIGYREAGAQHAGHALPVVLLHGIGSGAASWVCQLDTLGASRRVLAW
DAPGYGVSTPVHGASPTAADYAASLNAWLEALGIERCVLVGHSLGAIIAGGLSRLMPARIAGLLLISPAGGYGRAPAETR
DTRRDARLAMLEALGPAGLAEQRSGNMLSGFASEDARAWVRWNMARIVPAGYAQATHLLANADLATDLAGFRGRTAVAVG
ANDAITPPAACERIAAAAQVELQVIPQAGHAGYVEAPAVYSSLIDAFCRQCDTQRGMA

Download         Length: 897 bp

>T222951 NZ_CP118167:2049369-2049461 [Bacillus subtilis]
ATGTCAACATTCCAGGCATTAATGCTAATGCTTGCAATCGGGTCGTTTATAATCGCCCTATTGACGTATATAGAAAAAAT
AGACCTCCCTTGA

Antitoxin


Download         Length: 286 a.a.        Molecular weight: 31299.82 Da        Isoelectric Point: 6.6518

>AT222951 WP_228907974.1 NZ_CP086302:c1973264-1972407 [Burkholderia sp. B21-005]
MSEPLQQPESESTKADAGYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYK
LGIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQCQSPGFSAIRVNVGTRLPAHATTHGH
VLMGDLSLKELRALYPEGTLSRMTSATPETVDALYEVIREDALRGYGISNSSFERGISVVTAPVRNDTQKIVACITVTVP
RPEIDAALIADGLFDKVQRAAAELSRRLNYRSDDEHTFLKALGLR

Download         Length: 858 bp

>AT222951 NZ_CP118167:c2049615-2049442 [Bacillus subtilis]
TTACAATACATTACAGTGCATTTCTTTAATGAGAAATGCATAAAATAAAAAAGACCGAGGTGCTACCAACACCCCGGCTC
TGTACAAAAAGTTGCCCATCAAAGGGCTTGCTCGATGTGGTTCTAGGTAGGCCTATCCCTTCAGGTTCTGAGGCTCAAGG
GAGGTCTATTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References