Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/- |
| Location | 845630..846216 | Replicon | chromosome |
| Accession | NZ_CP086302 | ||
| Organism | Burkholderia sp. B21-005 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | - |
| Locus tag | LMA02_RS20185 | Protein ID | WP_228909530.1 |
| Coordinates | 845833..846216 (+) | Length | 128 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | - |
| Locus tag | LMA02_RS20180 | Protein ID | WP_228909529.1 |
| Coordinates | 845630..845836 (+) | Length | 69 a.a. |
Genomic Context
Location: 844456..845346 (891 bp)
Type: Others
Protein ID: WP_228909528.1
Type: Others
Protein ID: WP_228909528.1
Location: 845630..845836 (207 bp)
Type: Antitoxin
Protein ID: WP_228909529.1
Type: Antitoxin
Protein ID: WP_228909529.1
Location: 845833..846216 (384 bp)
Type: Toxin
Protein ID: WP_228909530.1
Type: Toxin
Protein ID: WP_228909530.1
Location: 841077..842063 (987 bp)
Type: Others
Protein ID: WP_228909526.1
Type: Others
Protein ID: WP_228909526.1
Location: 842163..842777 (615 bp)
Type: Others
Protein ID: WP_228910062.1
Type: Others
Protein ID: WP_228910062.1
Location: 842985..843209 (225 bp)
Type: Others
Protein ID: Protein_749
Type: Others
Protein ID: Protein_749
Location: 843342..844328 (987 bp)
Type: Others
Protein ID: WP_228909527.1
Type: Others
Protein ID: WP_228909527.1
Location: 846814..848433 (1620 bp)
Type: Others
Protein ID: WP_228909531.1
Type: Others
Protein ID: WP_228909531.1
Location: 848430..849531 (1102 bp)
Type: Others
Protein ID: Protein_755
Type: Others
Protein ID: Protein_755
Location: 849555..850178 (624 bp)
Type: Others
Protein ID: WP_228909532.1
Type: Others
Protein ID: WP_228909532.1
Location: 850175..851026 (852 bp)
Type: Others
Protein ID: WP_228909533.1
Type: Others
Protein ID: WP_228909533.1
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Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LMA02_RS20155 (LMA02_20165) | 841077..842063 | - | 987 | WP_228909526.1 | alpha/beta hydrolase | - |
| LMA02_RS20160 (LMA02_20170) | 842163..842777 | - | 615 | WP_228910062.1 | nitroreductase family protein | - |
| LMA02_RS20165 (LMA02_20175) | 842985..843209 | - | 225 | Protein_749 | DoxX family protein | - |
| LMA02_RS20170 (LMA02_20180) | 843342..844328 | - | 987 | WP_228909527.1 | zinc-binding dehydrogenase | - |
| LMA02_RS20175 (LMA02_20185) | 844456..845346 | + | 891 | WP_228909528.1 | LysR family transcriptional regulator | - |
| LMA02_RS20180 (LMA02_20190) | 845630..845836 | + | 207 | WP_228909529.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
| LMA02_RS20185 (LMA02_20195) | 845833..846216 | + | 384 | WP_228909530.1 | PIN domain-containing protein | Toxin |
| LMA02_RS20190 (LMA02_20200) | 846814..848433 | - | 1620 | WP_228909531.1 | FadD3 family acyl-CoA ligase | - |
| LMA02_RS20195 (LMA02_20205) | 848430..849531 | - | 1102 | Protein_755 | alkene reductase | - |
| LMA02_RS20200 (LMA02_20210) | 849555..850178 | - | 624 | WP_228909532.1 | nuclear transport factor 2 family protein | - |
| LMA02_RS20205 (LMA02_20215) | 850175..851026 | - | 852 | WP_228909533.1 | SDR family NAD(P)-dependent oxidoreductase | - |
Associated MGEs
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MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 844456..852541 | 8085 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 128 a.a. Molecular weight: 14325.65 Da Isoelectric Point: 6.2158
>T222949 WP_228909530.1 NZ_CP086302:845833-846216 [Burkholderia sp. B21-005]
MSVLVDTSVWVEHFRRPLPALIQLLLADDVLTHPLVMLELTCGTPPEPRARTLGDLALLRQTRLATSGEVADWIERERLY
GRGCGAVDCTLLASVLLTPRTWLWTRDRRLAQVADQFGVQYIPPDLH
MSVLVDTSVWVEHFRRPLPALIQLLLADDVLTHPLVMLELTCGTPPEPRARTLGDLALLRQTRLATSGEVADWIERERLY
GRGCGAVDCTLLASVLLTPRTWLWTRDRRLAQVADQFGVQYIPPDLH
Download Length: 384 bp
>T222949 NZ_CP118167:518550-518900 [Bacillus subtilis]
TTGATTGTGAAACGCGGCGATGTTTATTTTGCTGATTTATCTCCTGTTGTTGGCTCAGAGCAAGGCGGGGTGCGCCCGGT
TTTAGTGATCCAAAATGACATCGGAAATCGCTTCAGCCCAACTGCTATTGTTGCAGCCATAACAGCACAAATACAGAAAG
CGAAATTACCAACCCACGTCGAAATCGATGCAAAACGCTACGGTTTTGAAAGAGATTCCGTTATTTTGCTGGAGCAAATT
CGGACGATTGACAAGCAAAGGTTAACGGATAAGATTACTCATCTGGATGATGAAATGATGGATAAGGTTGATGAAGCCTT
ACAAATCAGTTTGGCACTCATTGATTTTTAG
TTGATTGTGAAACGCGGCGATGTTTATTTTGCTGATTTATCTCCTGTTGTTGGCTCAGAGCAAGGCGGGGTGCGCCCGGT
TTTAGTGATCCAAAATGACATCGGAAATCGCTTCAGCCCAACTGCTATTGTTGCAGCCATAACAGCACAAATACAGAAAG
CGAAATTACCAACCCACGTCGAAATCGATGCAAAACGCTACGGTTTTGAAAGAGATTCCGTTATTTTGCTGGAGCAAATT
CGGACGATTGACAAGCAAAGGTTAACGGATAAGATTACTCATCTGGATGATGAAATGATGGATAAGGTTGATGAAGCCTT
ACAAATCAGTTTGGCACTCATTGATTTTTAG
Antitoxin
Download Length: 69 a.a. Molecular weight: 7360.40 Da Isoelectric Point: 6.2353
>AT222949 WP_228909529.1 NZ_CP086302:845630-845836 [Burkholderia sp. B21-005]
MRTTVTVDDTLYARALELAEPGIPPADLFRAALETFVRVQAGQRLAALGGRAPDMPDVPRRNPTAADR
MRTTVTVDDTLYARALELAEPGIPPADLFRAALETFVRVQAGQRLAALGGRAPDMPDVPRRNPTAADR
Download Length: 207 bp
>AT222949 NZ_CP118167:518264-518545 [Bacillus subtilis]
TTGTCTGAATCCAGCGCAAGAACCGAAATGAAAATCAGCTTGCCCGAAAACCTAGTAGCTGAATTGGATGGTGTAGCGAT
GCGGGAGAAACGAAGCAGAAACGAACTGATATCACAAGCAGTGAGAGCGTATGTCAGCGAACGAACAACTCGTCACAACC
GTGATTTGATGAGACGCGGCTATATGGAAATGGCGAAAATCAACCTGAATATTTCTTCTGAGGCTCACTTTGCGGAGTGC
GAGGCTGAAACGACAGTTGAGCGCTTAGTCAGCGGAGGATAA
TTGTCTGAATCCAGCGCAAGAACCGAAATGAAAATCAGCTTGCCCGAAAACCTAGTAGCTGAATTGGATGGTGTAGCGAT
GCGGGAGAAACGAAGCAGAAACGAACTGATATCACAAGCAGTGAGAGCGTATGTCAGCGAACGAACAACTCGTCACAACC
GTGATTTGATGAGACGCGGCTATATGGAAATGGCGAAAATCAACCTGAATATTTCTTCTGAGGCTCACTTTGCGGAGTGC
GAGGCTGAAACGACAGTTGAGCGCTTAGTCAGCGGAGGATAA