Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 2700057..2700712 Replicon chromosome
Accession NZ_CP086298
Organism Burkholderia ambifaria strain B21-006

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LL998_RS28060 Protein ID WP_229081728.1
Coordinates 2700293..2700712 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LL998_RS28055 Protein ID WP_041491669.1
Coordinates 2700057..2700296 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LL998_RS28030 (LL998_28035) 2695321..2695716 - 396 WP_011659185.1 type II toxin-antitoxin system VapC family toxin -
LL998_RS28035 (LL998_28040) 2695713..2695952 - 240 WP_011659184.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
LL998_RS28040 (LL998_28045) 2696052..2696735 - 684 WP_229081726.1 Fe2+-dependent dioxygenase -
LL998_RS28045 (LL998_28050) 2696732..2697487 - 756 WP_165753459.1 tetratricopeptide repeat protein -
LL998_RS28050 (LL998_28055) 2697491..2699734 - 2244 WP_229081727.1 TonB-dependent siderophore receptor -
LL998_RS28055 (LL998_28060) 2700057..2700296 + 240 WP_041491669.1 Arc family DNA-binding protein Antitoxin
LL998_RS28060 (LL998_28065) 2700293..2700712 + 420 WP_229081728.1 type II toxin-antitoxin system VapC family toxin Toxin
LL998_RS28065 (LL998_28070) 2700854..2702149 - 1296 WP_006752949.1 aspartate carbamoyltransferase -
LL998_RS28070 (LL998_28075) 2702384..2702518 + 135 WP_011659177.1 entericidin A/B family lipoprotein -
LL998_RS28075 (LL998_28080) 2702618..2703190 - 573 WP_229081729.1 permease -
LL998_RS28080 (LL998_28085) 2703316..2704275 - 960 WP_229081730.1 DMT family transporter -
LL998_RS28085 (LL998_28090) 2704632..2705426 - 795 WP_229081731.1 AraC family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-122)

Antitoxin

Arc-like DNA binding domain

(7-44)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14985.23 Da        Isoelectric Point: 5.8818

>T222945 WP_229081728.1 NZ_CP086298:2700293-2700712 [Burkholderia ambifaria]
MILVDTNVISEPLRREPSAAVIEWLDAQNVETLFLAAISLAEMRFGVAALPEGRRRDWLHQSIEQRVVPLFRGRILPFDD
AASKAYASLRAKARATGNAMASADGFIAATAAANGLIVATRDVAPFEAVGLRVIDPWAG

Download         Length: 420 bp

>T222945 NZ_CP118165:1161518-1161856 [Glaesserella parasuis]
ATGAATGTCGCTTTTGTGGAGTTGCCGCCTTTTGAGGAATATAGAAAAAAGTATCTTGACGATGACTCATTTAGATTATT
ACAAAATGAGTTACTAAAATTTCCCGATAAGGGAGAGCTTATTCAAGGTACTGGGGGACTAAGAAAATTGCGTATTGTGG
ATATTATTAGACAAAAAGGAAAAAGAGGCGGAGCTAGGGTAATCTATTACTATTACGTGCGAGGGAAACAAGTTTGGTTG
TTCCACGCCTACAATAAAAACCAACAAGACGATTTATCTAATGAAGAACGTGTGGTTTTGGCGAATACATTAAGCTATTT
AAAATCTTTAGTGAGGTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8618.76 Da        Isoelectric Point: 6.4688

>AT222945 WP_041491669.1 NZ_CP086298:2700057-2700296 [Burkholderia ambifaria]
MPVITVRNLPDEVHRALRIRAAQHGRSTEAEVRAILEEAVRPTGRAKLGSLLAEIGREAGGVDFENPRESSPTAPMSFE

Download         Length: 240 bp

>AT222945 NZ_CP118165:1161860-1162168 [Glaesserella parasuis]
ATGGGAAAATTATTTAATGAACTAATGGAAGGGATGCAAGCATTAGAGTTACACTTACAAGGCAAAATTACACTAAAAAC
CACTGTTGTGGAAGTTCCTGATCCGATAGTAATTACCCCTGAAGAAGTGAAAGCTATTCGTCAGAAATTAAATCTTTCAC
AAGCCGTTTTTGCTCGTAAATTACACACTTCGGTGAGAACTTATCAAGGCTGGGAGCAAGGAAGAACAAAACCTAATCCA
CAAGCGGTTTTATTATTAAAAATGGTTGAAAAATCACCAAAAACATTTGAGCAGATTGCGAGCATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References