Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 2499198..2500444 Replicon chromosome
Accession NZ_CP086298
Organism Burkholderia ambifaria strain B21-006

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LL998_RS27145 Protein ID WP_175745865.1
Coordinates 2499198..2499779 (-) Length 194 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LL998_RS27150 Protein ID WP_229081626.1
Coordinates 2499887..2500444 (-) Length 186 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LL998_RS27125 (LL998_27130) 2494562..2495701 + 1140 WP_229081621.1 enoyl-CoA hydratase/isomerase family protein -
LL998_RS27130 (LL998_27135) 2495763..2496668 - 906 WP_229081623.1 LysR family transcriptional regulator -
LL998_RS27135 (LL998_27140) 2496846..2498384 + 1539 WP_229081624.1 MFS transporter -
LL998_RS27140 (LL998_27145) 2498414..2499142 - 729 WP_229081625.1 class I SAM-dependent methyltransferase -
LL998_RS27145 (LL998_27150) 2499198..2499779 - 582 WP_175745865.1 HD domain-containing protein Toxin
LL998_RS27150 (LL998_27155) 2499887..2500444 - 558 WP_229081626.1 helix-turn-helix transcriptional regulator Antitoxin
LL998_RS27155 (LL998_27160) 2500510..2501157 - 648 WP_175745864.1 hypothetical protein -
LL998_RS27160 (LL998_27165) 2501520..2502923 + 1404 WP_229081628.1 DUF308 domain-containing protein -
LL998_RS27165 (LL998_27170) 2503095..2503826 + 732 WP_175726545.1 ribonuclease T2 -
LL998_RS27170 (LL998_27175) 2503911..2504546 - 636 WP_229081629.1 isochorismatase family cysteine hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-168)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-64)


Sequences

Toxin        


Download         Length: 194 a.a.        Molecular weight: 21396.91 Da        Isoelectric Point: 4.7524

>T222944 WP_175745865.1 NZ_CP086298:c2499779-2499198 [Burkholderia ambifaria]
MNLDTIHARLDFLREAERLKDVLRSGHTSTGRPESTAEHSWRLCLMALVFADALPDVDTTKLLKLCVVHDLGEALHGDIP
AIEQAAHPDKSTHERDDLLTLTAGLDRALRDEIVALWDEYEAAESPEARAAKALDKLETILQHNQGSNPPDFDYAFNLGY
GRRYTDATPLFGAIRAIVDADTQRRIDARGDGA

Download         Length: 582 bp

>T222944 NZ_CP118165:c973939-973655 [Glaesserella parasuis]
ATGAGCTATACCATTGAATTTATCCCATCAGCAGAAAAAGAGTTCCGTAAACTAAGCTTAGATTTAAGAAAACAATTTAT
CGAAAAACTTAAAGAAAGAGCTGAAAATCCGCGTGTAGAAAGTGCTAAACTTCGTGGAATGAAAGATTGTTATAAAATCA
AATTGCGTAATGCAGGCTATCGTTTGGTATATCAAGTGATTGATGAACGTATTGTAATCAAAGTGGTTGCACAGGGAAAA
AGGGAGCGCAACGACGTTTACCAAAAAGTACAATTACGTTTATAA

Antitoxin


Download         Length: 186 a.a.        Molecular weight: 20284.28 Da        Isoelectric Point: 11.0874

>AT222944 WP_229081626.1 NZ_CP086298:c2500444-2499887 [Burkholderia ambifaria]
MTTSPLHTPPLGPQLKRWRTLRRVKQSHAAELFGVAQSTISRWEAGIQQMSPDERATAERLLAARLDSAGDHALARLIAS
STARMHLVCDLTHRLLACSPSRAAEFSRPLPVLLGTSLWRYASPEIVRMEAALDPLGWHDRAGPPSVEFATGTNASRVVP
IRGSTCRWTRMTLSDGSAARLVETL

Download         Length: 558 bp

>AT222944 NZ_CP118165:c974190-973936 [Glaesserella parasuis]
ATGCCAAGTGTTATTTTAACCAATACTGTTGCGAGTATTACAGAGCTAAAGACAAATCCAATGGCGACATTCAATGCGGC
AGGCGGTGAGGCAATTGCAATTTTAAACCGAAATGAACCCGCTTTTTATTGTGTACCACCGCATATTTATGAATATCTCA
TTGAGCTTGCTGATGATGCAGAATTAGCAAAATTAGTGGAAGAACGCCAACACGAAAAAAGCTACAAAGTGGATTTAGCG
GATTTATTAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References