Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 1939178..1939697 Replicon chromosome
Accession NZ_CP086298
Organism Burkholderia ambifaria strain B21-006

Toxin (Protein)


Gene name relE Uniprot ID B1Z1X1
Locus tag LL998_RS24670 Protein ID WP_012367044.1
Coordinates 1939416..1939697 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q0B637
Locus tag LL998_RS24665 Protein ID WP_011659781.1
Coordinates 1939178..1939426 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LL998_RS24655 (LL998_24660) 1936484..1937674 + 1191 WP_229081226.1 2-methylaconitate cis-trans isomerase PrpF -
LL998_RS24660 (LL998_24665) 1937983..1939035 + 1053 WP_229081227.1 CaiB/BaiF CoA-transferase family protein -
LL998_RS24665 (LL998_24670) 1939178..1939426 + 249 WP_011659781.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LL998_RS24670 (LL998_24675) 1939416..1939697 + 282 WP_012367044.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LL998_RS24675 (LL998_24680) 1939816..1940259 - 444 WP_006757720.1 PaaI family thioesterase -
LL998_RS24680 (LL998_24685) 1940569..1941891 + 1323 WP_229082684.1 IS4 family transposase -
LL998_RS24685 (LL998_24690) 1941953..1943578 + 1626 WP_229081228.1 methyl-accepting chemotaxis protein -
LL998_RS24690 (LL998_24695) 1943551..1944660 - 1110 WP_229081229.1 AGE family epimerase/isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-81)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10983.88 Da        Isoelectric Point: 10.7091

>T222943 WP_012367044.1 NZ_CP086298:1939416-1939697 [Burkholderia ambifaria]
MTFELAFLEPALKEWKKLDRTIRDQFKSRLAERLENPRIASAKLHGHPDRYKIKLRSVGYRLVYEVRDTEVIVLVVAVGR
RDRDAVYLAAMKR

Download         Length: 282 bp

>T222943 NZ_CP118165:587906-588184 [Glaesserella parasuis]
ATGATTATTTCATTTAAGCATAAAGGATTGAAATTATTTTTTGAAACAGGATCAACCGCAGGTATTCAAGCAAATCACGC
TAGTAAACTTGCTTTTCAATTAGCCACTCTAAACCAAGCAAAAAGTGCTTTAGATATGAATGCACCTAGCTGGAATTTAC
ATCAATTACAAGGTAATTTAGCTGGGCATTGGTCTATCAAGGTAAGTGGAAATTGGCGTTTAACTTTTAAATTTCAAAAT
GGTCACGCTGAAGTCGTGGACTATCAAGATTATCATTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8989.36 Da        Isoelectric Point: 5.6566

>AT222943 WP_011659781.1 NZ_CP086298:1939178-1939426 [Burkholderia ambifaria]
MPHTILANVTASVSELKRNPMGTVAAGEGFPVAILNHNEPAFYCIPAKTWEAMVERLEDIEDNALANTRAKDKVVKVKLN
DL

Download         Length: 249 bp

>AT222943 NZ_CP118165:588195-588467 [Glaesserella parasuis]
ATGAAAATGTACAATCCAGCTCACCCAGGGCTTATTTTAAGAGAATATATTGAAGGATATAATGTCACAGAAGTGGCTAA
ACGTTTAGGTGTCACTCGTGTCACGCTCTCTCGTATTTTAAATGGCAAAGCCGCAATTTCACCTGAAATGGCTCTTAGAT
TAAGCCAATTATTAAAAACTAGCCCAGAATTATGGCTTGGTTTACAATCCCAATACGATCTTTGGCAGCTTGAACAACGC
CCAAGTTTTAATATTCAGCCGTTATTTGCATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B1Z1X1

Antitoxin

Source ID Structure
AlphaFold DB Q0B637

References