Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-PumB/upstrm_HI1419-dnstrm_HI1420
Location 1171654..1172274 Replicon chromosome
Accession NZ_CP086298
Organism Burkholderia ambifaria strain B21-006

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag LL998_RS21235 Protein ID WP_175789935.1
Coordinates 1171654..1171971 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag LL998_RS21240 Protein ID WP_006750245.1
Coordinates 1171975..1172274 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LL998_RS21225 (LL998_21230) 1168227..1169658 - 1432 Protein_1011 aldehyde dehydrogenase family protein -
LL998_RS21230 (LL998_21235) 1169687..1171327 - 1641 WP_175729498.1 acetolactate synthase large subunit -
LL998_RS21235 (LL998_21240) 1171654..1171971 + 318 WP_175789935.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LL998_RS21240 (LL998_21245) 1171975..1172274 + 300 WP_006750245.1 putative addiction module antidote protein Antitoxin
LL998_RS21245 (LL998_21250) 1172335..1173621 - 1287 WP_165752680.1 DUF445 domain-containing protein -
LL998_RS21250 (LL998_21255) 1173812..1175032 - 1221 WP_229082476.1 anthranilate 1,2-dioxygenase system ferredoxin--NAD(+) reductase -
LL998_RS21255 (LL998_21260) 1175022..1175348 - 327 WP_126226709.1 anthranilate 1,2-dioxygenase ferredoxin subunit AndAb -
LL998_RS21260 (LL998_21265) 1175365..1175853 - 489 WP_011660415.1 anthranilate 1,2-dioxygenase small subunit AndAd -
LL998_RS21265 (LL998_21270) 1175850..1177139 - 1290 WP_105830063.1 anthranilate 1,2-dioxygenase large subunit AndAc -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(19-94)

Antitoxin

Uncharacterized protein HI1420

(5-93)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 11809.55 Da        Isoelectric Point: 9.9422

>T222942 WP_175789935.1 NZ_CP086298:1171654-1171971 [Burkholderia ambifaria]
MPYSAPAFSIRTTDVFDAWFAGLQDRVAKRRIQARIDRLSMGNPGDWKSAGSPVVEMRIDHGPGYRVYYVRRGTIWVILL
CGGDKSTQQADIRAAHAMLARLDLE

Download         Length: 318 bp

>T222942 NZ_CP118165:389438-389782 [Glaesserella parasuis]
ATGGAAACAGAAGAATATCTTACTTTTATTGAAACCAAAATCTTTGAAGAAGACCGAAAAGCATTGATGTCTGATGATGA
ATATCAGAAATTTCAGGCTTATTTATTAGAATCTCACGAATTAGGCGATTTTATTCAGAATACTGGTGGTTGCCAAAAAA
TTCGCTGGAAACTAGAAAGTAATAACAAGGGCAAAAGTGGTGGTGTAAGGGTGATTTACTATGTTGTAACCAAACAGGGA
AAATTATTATTAATGATGATGTATGCTAAAAGCAAACAAGACAATATGAGTGATAAACAAAAAGCAATGTTAAAAGCGGT
TGTATCTCAATTAAGTGAGGAGTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10674.11 Da        Isoelectric Point: 6.6384

>AT222942 WP_006750245.1 NZ_CP086298:1171975-1172274 [Burkholderia ambifaria]
MDKIKTRPWDSAEHLKTDDDMADYFEACLQEAGDDPAFIAHALGVIARARGMSQVARDAGLSREGLYKALSHDGNPSFGT
ILKVIKALGLQLHGAKAHA

Download         Length: 300 bp

>AT222942 NZ_CP118165:389785-390081 [Glaesserella parasuis]
ATGGAAAAAGAACTTTTTGAACGTCTAATGGAAAGTGCGAGAGAAATGGTCGCCATTGAAAAAGGCGAAATAGAAGTACC
ACCACATCGTATTCATATCCATAAAATCCCGAATGTCAAAGCGATTAGAACCCTGCATCAGATGAAACAAGCAGAATTTG
CTTCCCTTTTAGGCGTAAGCCAAAACCTTGTGCAGTCGTGGGAAATCGGCAGACGAACCCCAAATGGCGCTGCACGGAAA
TTGCTTGCGATTATTGAGCAACAGCCAGAACTTATCCCTGTATTACAAGGGCTTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References