Detailed information of TA system TA222941

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 853580..854226
• Replicon: chromosome
• Accession: NZ_CP086298
• Organism: Burkholderia ambifaria strain B21-006

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: LL998_RS19775
• Protein ID: WP_229082337.1
• Coordinates: 853580..853987 (-)
• Length: 136 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: Q0BA09
• Locus tag: LL998_RS19780
• Protein ID: WP_011658485.1
• Coordinates: 853984..854226 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LL998_RS19760 (LL998_19775)	849369..849953	-	585	WP_229082334.1	hypothetical protein	-
LL998_RS19765 (LL998_19780)	849950..850690	-	741	WP_229082335.1	methyl-accepting chemotaxis protein	-
LL998_RS19770 (LL998_19785)	850693..853083	-	2391	WP_229082336.1	MCP four helix bundle domain-containing protein	-
LL998_RS19775 (LL998_19790)	853580..853987	-	408	WP_229082337.1	type II toxin-antitoxin system VapC family toxin	Toxin
LL998_RS19780 (LL998_19795)	853984..854226	-	243	WP_011658485.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
LL998_RS19785 (LL998_19800)	854488..855177	+	690	WP_229082338.1	phospholipase	-
LL998_RS19790 (LL998_19805)	855222..856715	-	1494	WP_175705581.1	amino acid permease	-
LL998_RS19795 (LL998_19810)	856819..858225	-	1407	WP_011658482.1	aspartate ammonia-lyase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-122)

Antitoxin

• SpoVT-AbrB domain (7-51)

Sequences

Toxin

Protein

• Length: 136 a.a.
• Molecular weight: 14839.97 Da
• Isoelectric Point: 6.6466

>T222941 WP_229082337.1 NZ_CP086298:c853987-853580 [Burkholderia ambifaria]
MKFLLDTHAVIAILKGEQAMLARLRSHQPADFGIPAIVAHELYYGAYKSQRAAANLARVEGLQFEVVSVDAEDAQHAGEI
RAQLAAVGTPIGPYDALIAGQARARRLVLVTHNTREFERVPELQVEDWLAAAREK

Nucleotide

• Length: 408 bp

>T222941 NZ_CP118165:c274438-273938 [Glaesserella parasuis]
ATGAAGAGTAAGTTTATTGAAGAGCCTTTAACGAAGCATCATCAACGTGAAGCCTTTGATTGCGGAAATCTAGAGATGAA
CCGATTTTTTAAACAATACGCTCGGCAATCTCACGAAAAAGGGACATCAAAAACTTACATTAGCCGACACTTAGACAGTC
AACAGATTATCGGATTTTATACAATCACCTTAAGTGCATTAGACCAGCAACACTTACCCGAACTATGCAAAAAACGTTTT
GGCTACCACCCTATTCCGCTCTTTACATTAGCAAGACTTGCAGTGGATATTCGCTATCAAAAACAAGGCATTGGCGGAAT
GCTGTTGGTTAAAGCTCTCAAACGCTGTGCCATCGTTGCCGAACAAGTCTGGGGAATTGGGCTTCTCATTGAAGCAAAAG
ATGAAGACATTTCTCGTTGGTATCAATCTTATGGTGCTATTCCATTGGAAAATATGCCATTAACCTTAATTCTACTCTTT
GATACAATCAAAGGACTTTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8872.03 Da
• Isoelectric Point: 4.7628

>AT222941 WP_011658485.1 NZ_CP086298:c854226-853984 [Burkholderia ambifaria]
METAKIFKHGGSQAVRLPKDFRFDTTEVRIRRHGASVILEPVPQDWAWLTPLIGPVDADFEAAAATEPAAQERPGLDVFE

Nucleotide

• Length: 243 bp

>AT222941 NZ_CP118165:c274715-274428 [Glaesserella parasuis]
ATGCCACAAATTGCAAATGCCCTTAACGATAGAATGTCTATTCGCATTAGTACGGAAGACAAGCAGACTTTAATTAGAGC
CGTTGCACTTACCCATACGAATATTACGGAATTTGTATTACAACGTATTTTGCCTAGTGCCAGAGAAATTATTCAGCAGT
ATGATAATCGGCAATTTTCACCGCAAGATCTCTCGTTGATTATGGAATTGCTTGATAATCCGCCGAAAGCTAATACAAAA
CTACAACAAGCGGCGAAATTAGCAAAGGAAAGCTATCATGAAGAGTAA

Structures

Antitoxin

• AlphaFold DB: A0A3P0NDJ4