Detailed information of TA system TA222939

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/ParE-RHH
• Location: 301346..301902
• Replicon: chromosome
• Accession: NZ_CP086298
• Organism: Burkholderia ambifaria strain B21-006

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: LL998_RS17495
• Protein ID: WP_229081981.1
• Coordinates: 301612..301902 (+)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: B1T1D3
• Locus tag: LL998_RS17490
• Protein ID: WP_006757580.1
• Coordinates: 301346..301624 (+)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LL998_RS17460 (LL998_17470)	296561..296953	+	393	WP_126225468.1	hypothetical protein	-
LL998_RS17465 (LL998_17475)	297487..298881	+	1395	WP_229081973.1	DUF1800 domain-containing protein	-
LL998_RS17470 (LL998_17480)	298884..300047	+	1164	WP_229081975.1	DUF1501 domain-containing protein	-
LL998_RS17475 (LL998_17485)	300106..300324	+	219	WP_229063867.1	YXWGXW repeat-containing protein	-
LL998_RS17480 (LL998_17490)	300355..300509	-	155	Protein_264	integrase	-
LL998_RS17485 (LL998_17495)	300830..301210	+	381	WP_229081977.1	DUF4377 domain-containing protein	-
LL998_RS17490 (LL998_17500)	301346..301624	+	279	WP_006757580.1	CopG family ribbon-helix-helix protein	Antitoxin
LL998_RS17495 (LL998_17505)	301612..301902	+	291	WP_229081981.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LL998_RS17500 (LL998_17510)	302045..303433	-	1389	WP_229081982.1	DHA2 family efflux MFS transporter permease subunit	-
LL998_RS17505 (LL998_17515)	303574..304443	+	870	WP_175659163.1	LysR substrate-binding domain-containing protein	-
LL998_RS17510 (LL998_17520)	305170..306396	-	1227	WP_229081983.1	acyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	292006..322664	30658

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-94)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11023.58 Da
• Isoelectric Point: 9.5554

>T222939 WP_229081981.1 NZ_CP086298:301612-301902 [Burkholderia ambifaria]
MPQVIFAPAAIRDLQRMRDFLLSKNPDAARRAGEAIRRGVLALGTHPRMGRLIEDFPEQYREWTIDFGDSGYLARYRFDG
DTVTILAVRHQKEAGY

Nucleotide

• Length: 291 bp

>T222939 NZ_CP118163:875232-875585 [Staphylococcus hyicus]
ATGAAACGTGGCGACGTTTATTTAGCAGATTTATCGCCAGTACAAGGGTCGGAACAAGGGGGAGTCAGACCTGTCGTTAT
CATTCAAAATGATACTGGCAACAAGTATAGTCCAACTGTTATTGTTGCTGCAATTACTGGACGAATTAATAAAGCTAAAA
TTCCAACACATGTTGAAATTGAAAAACATAAGTATAAGCTCGATAAAGACTCTGTTATCTTATTAGAACAAATAAGGACA
GTTGATAAGAAGAGGCTTAAAGAAAAGTTGACCTATCTTTCGGATAAAAAAATGAAAGAAGTAAACGCAGCACTTGGAAT
TAGTCTAGGATTGCACATGAACCAACATAAATAG

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10730.97 Da
• Isoelectric Point: 4.9654

>AT222939 WP_006757580.1 NZ_CP086298:301346-301624 [Burkholderia ambifaria]
MVTATSIKLDDELKGRVQHLAEARRRTAHWIMREAIEQYVEREEKREALNQDTLKAWDEFQATGLHATAEEVDKWLASWG
TENELPSPECHK

Nucleotide

• Length: 279 bp

>AT222939 NZ_CP118163:875061-875231 [Staphylococcus hyicus]
ATGTCATCATTCTATCAAACAAGAGGTAAAAGCTTAGAACAATTGTTAAAAGAAGGGTATGTTCAGATGGCGGATTTAAA
TCTCTCCCTAGCAACAGAAGCATACTCCGTTGAATGTGAAGCTTGTGATTGTAATGAATCACACTTACTTTCTAACAATA
AGGATGACTAA

Structures

Antitoxin

• AlphaFold DB: B1T1D3