Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 1768539..1769224 Replicon chromosome
Accession NZ_CP086297
Organism Burkholderia ambifaria strain B21-006

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag LL998_RS08310 Protein ID WP_229079043.1
Coordinates 1768802..1769224 (+) Length 141 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag LL998_RS08305 Protein ID WP_126227837.1
Coordinates 1768539..1768805 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LL998_RS08290 (LL998_08295) 1764057..1766318 + 2262 WP_229079041.1 TonB-dependent siderophore receptor -
LL998_RS08295 (LL998_08300) 1766405..1767244 + 840 WP_006755049.1 formyltransferase family protein -
LL998_RS08300 (LL998_08305) 1767244..1768260 + 1017 WP_229079042.1 GNAT family N-acetyltransferase -
LL998_RS08305 (LL998_08310) 1768539..1768805 + 267 WP_126227837.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LL998_RS08310 (LL998_08315) 1768802..1769224 + 423 WP_229079043.1 type II toxin-antitoxin system VapC family toxin Toxin
LL998_RS08315 (LL998_08320) 1769305..1769820 - 516 WP_229079044.1 MaoC family dehydratase -
LL998_RS08320 (LL998_08325) 1769838..1770890 + 1053 WP_229079045.1 transposase -
LL998_RS08325 (LL998_08330) 1771178..1772083 - 906 WP_175715648.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
LL998_RS08330 (LL998_08335) 1772052..1773248 - 1197 WP_267478633.1 type IV toxin-antitoxin system AbiEi family antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-130)

Antitoxin

SpoVT-AbrB domain

(7-54)


Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 14784.89 Da        Isoelectric Point: 7.8895

>T222937 WP_229079043.1 NZ_CP086297:1768802-1769224 [Burkholderia ambifaria]
VTTLYMLDTNICSFIMRERPAAVLSRLQSCVNAQHRIVVSAITYAEMRFGAVGRKASPKHPELVTAFVSRLDGVLSWDTA
AVDATTAIRVDLAARGTPIGANDASIAGHAIAAGAVLVTNNSREFSRVAGLSLEDWAASA

Download         Length: 423 bp

>T222937 NZ_CP118156:c6220421-6220122 [Pseudomonas chlororaphis]
ATGATCGAGATCAAACAGACCGCGACCTTTATGGAGTGGGAAAACAGGCTCAAGGATTCCAGAGCCAGGGCGTTGATTGC
TGCGCGGATTTTTCGCTTGGCCAACGGTCTTGCCGGGGACGTGTCGCCGGTGGGCGAAGGCGTCAGCGAGCTGCGCATCC
ATTACGGGCCGGGCTACCGGGTTTACTTCCAGCAGCGCGGCTTGCAACTCGTCATTCTGTTGTGCGGCGGCGACAAGAGT
CGCCAGGGCCGCGATATCGAACTGGCCAAACAGCTGGCCCGTCGTTGGAGCCGATCATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9972.25 Da        Isoelectric Point: 4.5386

>AT222937 WP_126227837.1 NZ_CP086297:1768539-1768805 [Burkholderia ambifaria]
MRTVSIFKNARNQAIRIPKDMEFEGVTELEIRREGDTLLLRPVRPTWLSFATEPRADADFLVERPTVVEAGRFDLPGADD
DAPTESAR

Download         Length: 267 bp

>AT222937 NZ_CP118156:c6220125-6219832 [Pseudomonas chlororaphis]
ATGAACGAACCGCTTTTCGACTATGACCCCGCCACGGCCCTGCGTGACCCGCAAGCCATTGCCCTGTTCATGGCGGACGC
CTTCGAGACCGGCGATGCCGGCTACATCGCCAAAGCCCTGGGCGTGGTGGCGCGGGCCAAGGGCATGACCGAACTGGCCC
ATGAAACCGGGCTGTCCCGCGAGCAGCTGTACCGCTCATTCAGCGACAAGGGCAACCCGACCCTGAAGACCCTGCTGGCG
GTGATGCGTGCACTGGGGCTGGACATGACGGCGCGGGTGCATGGGGCGTCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References