222935

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-PumB/upstrm_HI1419-dnstrm_HI1420
Location 2031285..2031905 Replicon chromosome
Accession NZ_CP086295
Organism Burkholderia sp. B21-007

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag LMA01_RS25740 Protein ID WP_229050582.1
Coordinates 2031285..2031602 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag LMA01_RS25745 Protein ID WP_228909369.1
Coordinates 2031606..2031905 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LMA01_RS25730 (LMA01_25750) 2027857..2029290 - 1434 WP_006756588.1 aldehyde dehydrogenase family protein -
LMA01_RS25735 (LMA01_25755) 2029319..2030959 - 1641 WP_228909375.1 acetolactate synthase large subunit -
LMA01_RS25740 (LMA01_25760) 2031285..2031602 + 318 WP_229050582.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LMA01_RS25745 (LMA01_25765) 2031606..2031905 + 300 WP_228909369.1 putative addiction module antidote protein Antitoxin
LMA01_RS25750 (LMA01_25770) 2031948..2033234 - 1287 WP_228909367.1 DUF445 domain-containing protein -
LMA01_RS25755 (LMA01_25775) 2033416..2034636 - 1221 WP_228909365.1 anthranilate 1,2-dioxygenase system ferredoxin--NAD(+) reductase -
LMA01_RS25760 (LMA01_25780) 2034626..2034952 - 327 WP_006756593.1 anthranilate 1,2-dioxygenase ferredoxin subunit AndAb -
LMA01_RS25765 (LMA01_25785) 2034969..2035457 - 489 WP_105830064.1 anthranilate 1,2-dioxygenase small subunit AndAd -
LMA01_RS25770 (LMA01_25790) 2035472..2036743 - 1272 WP_228909363.1 anthranilate 1,2-dioxygenase large subunit AndAc -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(9-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(48-90)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 11809.49 Da        Isoelectric Point: 9.9422

>T222935 WP_229050582.1 NZ_CP086295:2031285-2031602 [Burkholderia sp. B21-007]
MPYSAPTFSIRTTDVFDAWFAGLQDRVAKRRIQARIDRLSMGNPGDWKSAGSPVVETRIDHGPGYRVYYVRRGTIWVILL
CGGDKSTQQADIRAAHAMLARLDLE

Download         Length: 318 bp

>T222935 NZ_CP118156:c4226049-4225768 [Pseudomonas chlororaphis]
ATGACTTATGAGCTGGAGTTCTCCGAGAAAGCCTGGAAGGAATGGCAAAAGCTGGGCCCCACGCTGAAAGAGCAATTCAA
GAAGAAGCTGCAGGAACGACTCGTCAACCCCCATGTTCCGGCTGATCGCCTGAGCGGTTTGGGCAATGCCTACAAAATCA
AATTACGTACGGCGGGCTACCGCCTGGTGTATCGGGTGGTGGATGAGGTGTTGGTGGTGACGGTCATTGCCGTGGGCAAG
CGGGAGCGGGGGAGTGTCTATCAGCAAGCTAGGAAGCGTTAG

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10676.08 Da        Isoelectric Point: 6.6384

>AT222935 WP_228909369.1 NZ_CP086295:2031606-2031905 [Burkholderia sp. B21-007]
MDKIKTRPWDSAEHLKTDDDMADYFEACLQEGGDDPAFIAHALGVIARARGMSQVSRDAGLSREGLYKALSHDGNPSFGT
ILKVIKALGLQLHGAKAHA

Download         Length: 300 bp

>AT222935 NZ_CP118156:c4226287-4226039 [Pseudomonas chlororaphis]
ATGACCCATGTTCTTCTGTCCAATGTCGTCGCGAGCATTTCCGAGCTCAAGAAAAACCCCATGGGCACCGTTGCGGCCGG
TGGCGGTTCCTCCGTGGCCATTCTCAATCGCAATGAACCGGCGTTTTACTGCGTTCCGGCCAAGGAATACGAAGCGATGA
TGGAGCGTCTGGAGGATATGGAGCTGCTCGCCTTGTGCCGTGAGCGAGAGAATGATCCGACCATCAAGGTTTCGCTCGAT
GACTTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References