Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 1767767..1768353 Replicon chromosome
Accession NZ_CP086295
Organism Burkholderia sp. B21-007

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LMA01_RS24565 Protein ID WP_228909530.1
Coordinates 1767767..1768150 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LMA01_RS24570 Protein ID WP_228909529.1
Coordinates 1768147..1768353 (-) Length 69 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LMA01_RS24545 (LMA01_24565) 1762957..1763808 + 852 WP_228909533.1 SDR family NAD(P)-dependent oxidoreductase -
LMA01_RS24550 (LMA01_24570) 1763805..1764428 + 624 WP_228909532.1 nuclear transport factor 2 family protein -
LMA01_RS24555 (LMA01_24575) 1764452..1765553 + 1102 Protein_1635 alkene reductase -
LMA01_RS24560 (LMA01_24580) 1765550..1767169 + 1620 WP_228909531.1 FadD3 family acyl-CoA ligase -
LMA01_RS24565 (LMA01_24585) 1767767..1768150 - 384 WP_228909530.1 PIN domain-containing protein Toxin
LMA01_RS24570 (LMA01_24590) 1768147..1768353 - 207 WP_228909529.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LMA01_RS24575 (LMA01_24595) 1768637..1769527 - 891 WP_228909528.1 LysR family transcriptional regulator -
LMA01_RS24580 (LMA01_24600) 1769655..1770641 + 987 WP_228909527.1 zinc-binding dehydrogenase -
LMA01_RS24585 (LMA01_24605) 1770774..1770998 + 225 Protein_1641 DoxX family protein -
LMA01_RS24590 (LMA01_24610) 1771206..1771820 + 615 WP_228910062.1 nitroreductase family protein -
LMA01_RS24595 (LMA01_24615) 1771920..1772906 + 987 WP_228909526.1 alpha/beta hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1761840..1783453 21613


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-114)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14325.65 Da        Isoelectric Point: 6.2158

>T222934 WP_228909530.1 NZ_CP086295:c1768150-1767767 [Burkholderia sp. B21-007]
MSVLVDTSVWVEHFRRPLPALIQLLLADDVLTHPLVMLELTCGTPPEPRARTLGDLALLRQTRLATSGEVADWIERERLY
GRGCGAVDCTLLASVLLTPRTWLWTRDRRLAQVADQFGVQYIPPDLH

Download         Length: 384 bp

>T222934 NZ_CP118156:c2840468-2839824 [Pseudomonas chlororaphis]
ATGAATTACAGCAGACTGAATCCAGAGAAAGCTCTGATCTGGCGTATCGTCCATCGCGACAATCTGCCTTGGATTCTGGA
CAACGGTCTGCATTGCGCAAGCTCCGACGTACAGGCACCACAGTATGTGAATATTGGCAACGTTGACCTGATCAGCAAGC
GCCGATCCCGTCATGTGCCCATTACTCCAGGTGGGGTACTGGCCGATTACGTGCCCTTCTATTTCACCCCCTTCTCTGTG
ATGATGAAAAACATTCACTCAGGGTGGAGTGTTCAACAGCGAAGCAACGACGAGATAGTGATTCTGGTCTCAAGTTTGTA
CCGCGTTGAGCAGTTAGGTTTACCGTTTGTCTTCACAAATGCACATGCCTACCCGGATTGGACAAACTATTACAGCGATC
TGGCGAATCTCAGCCAGATCGACTGGTCTATCCTTCAGCGACGCGACTTCAAGCGCGACCCTGATGACCCTCGAAAAATG
GAGCGCTATCAGGCTGAAGCGCTAATTCACCATCACCTACCGATTACAGGACTCCTTGGCATCATGTGCCACACCGATGC
AATGAAAGAATGCATAGAACAAGACGTGACCGACAGAGGGTTGGCCTTACCTGTTCATGCCCGTCCGGGATGGTATTTCC
AATGA

Antitoxin


Download         Length: 69 a.a.        Molecular weight: 7360.40 Da        Isoelectric Point: 6.2353

>AT222934 WP_228909529.1 NZ_CP086295:c1768353-1768147 [Burkholderia sp. B21-007]
MRTTVTVDDTLYARALELAEPGIPPADLFRAALETFVRVQAGQRLAALGGRAPDMPDVPRRNPTAADR

Download         Length: 207 bp

>AT222934 NZ_CP118156:c2839827-2838739 [Pseudomonas chlororaphis]
ATGATCCGTTTTACCCAAGGCAACCTTCTGGAAGCCAAAACCGAAGCCCTGGTCAACACGGTGAATACCGTAGGCGTAAT
GGGTAAAGGTATCGCGCTGATGTTTAAAGAGCGCTTTTCTGAGAATTACCGTCTGTACTCGGCTGCCTGTAAGGCTGGCG
AAGTGGAGACAGGCAGAATGCACGTGACAGCCGTCAACGAGCTGGACGGACCTCGCTGGATCGTGAATTTCCCAACCAAA
CGTCACTGGCGATCACCGTCGCAGATGGCTTGGGTGACGGAAGGTTTGCATGACTTACGTCGCTTCTTGATTGAAAACCA
GGTGAAGTCAGTGGCGGTTCCACCACTAGGAGCCGGCAATGGCGGCTTAAAATGGCCTGAAGTTCGCGAACAGATAGTCA
CCGTATTGGGTGACCTGGATGTGGACATTCTGGTGTTCGAGCCCTCCAACCAGTATTTGAATGTCGCCAAGCGTAGCGGT
GTGGAAAAGCTCACACCTGCTCGTGCCCTAATTGCCGAACTGGTTCGACGCTATTGGATTTTAGGCATGGAATGCAGCTT
GCTTGAAATTCAGAAACTAGCTTGGTTTCTTGAACGAGCTATAGAAAAGCTACCGGCCACCGAAAACCCATTGAACCTTA
AATTTGTGGCTCACAAATACGGACCGTACGCCAACAGACTGGAGCATCTACTCAATAACCTGGATGGGAGCTATCTGCAC
TGCAACAAACGCATCAGCGATGCGGGTATCAGTGATGTGATCTGGTTTGATGAAGAGCGTAAAGCCTTTCTGCAAACCTA
TCTCAAGACAGAAGCCAAGGAGTACTCACAAGCTCTGGAGCATACTGCCAAGCTGATTGATGGCTTTGAGTCCCCCTTCG
GTATGGAGTTATTGGCAACGGTCGATTGGTTGCTGAGTCAAGAAGGGATTTCTCCAACTGTTCCTGCCATGCGCGACGCG
TTGAAGAATTGGGATGGCGGAGCCGGTGCTGCTGTCCGAAAAAGCAGGCTGTTCGACGATCAGGCGCTTGATATCGCGCT
CAAACGCCTGACCTCAAGTAGTTTCATGCCTGAAATGGCTACCTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References