Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 403253..403908 Replicon chromosome
Accession NZ_CP086295
Organism Burkholderia sp. B21-007

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LMA01_RS18285 Protein ID WP_228908117.1
Coordinates 403489..403908 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LMA01_RS18280 Protein ID WP_228910013.1
Coordinates 403253..403492 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LMA01_RS18260 (LMA01_18270) 398544..399017 - 474 WP_228908121.1 AidA/PixA family protein -
LMA01_RS18265 (LMA01_18275) 399251..399934 - 684 WP_228908120.1 Fe2+-dependent dioxygenase -
LMA01_RS18270 (LMA01_18280) 399931..400686 - 756 WP_228908119.1 tetratricopeptide repeat protein -
LMA01_RS18275 (LMA01_18285) 400690..402933 - 2244 WP_228908118.1 TonB-dependent siderophore receptor -
LMA01_RS18280 (LMA01_18290) 403253..403492 + 240 WP_228910013.1 Arc family DNA-binding protein Antitoxin
LMA01_RS18285 (LMA01_18295) 403489..403908 + 420 WP_228908117.1 type II toxin-antitoxin system VapC family toxin Toxin
LMA01_RS18290 (LMA01_18300) 404047..405342 - 1296 WP_006758102.1 aspartate carbamoyltransferase -
LMA01_RS18295 (LMA01_18305) 405577..405711 + 135 WP_011659177.1 entericidin A/B family lipoprotein -
LMA01_RS18300 (LMA01_18310) 405811..406383 - 573 WP_228908116.1 permease -
LMA01_RS18305 (LMA01_18315) 406509..407468 - 960 WP_228908115.1 DMT family transporter -
LMA01_RS18310 (LMA01_18320) 407783..408577 - 795 WP_228908114.1 AraC family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-122)

Antitoxin

Arc-like DNA binding domain

(7-43)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15118.43 Da        Isoelectric Point: 7.2064

>T222931 WP_228908117.1 NZ_CP086295:403489-403908 [Burkholderia sp. B21-007]
MILVDTNVISEPLRREPSAAVIEWLDAQNVETLFLAAISLAEMRFGVAALQEGRRRDWLHQSIEHRVVPLFRGRILPFDD
AASKAYASLRAKARVTGNAMASADGLIAATAAANGLIVATRDVVPFEAAGLRVIDPWAR

Download         Length: 420 bp

>T222931 NZ_CP118156:c1780113-1779931 [Pseudomonas chlororaphis]
GTGGACAGTCGGTATTTGATCGGCCAAATCGTCGCAGACGGTTGGTATCTAGTCAGGGTCAGGGGCAGTCACCACCATTT
CAAGCATCCCCATAAACCGGGGCTGGTGACCGTTCCCCATCCCAAAAAGGACCTGCTGAGAAAAACCGCCATCAGCATTC
TGAAACAGGCGCTGCTCATGTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8613.82 Da        Isoelectric Point: 5.7084

>AT222931 WP_228910013.1 NZ_CP086295:403253-403492 [Burkholderia sp. B21-007]
MPVITVRNLPDEVHRALRVRAAQHGRSTEAEVRAILEEAVRPGGRAKLGTLLAEIGREAGGVDFEIPRESAPIDPMSFE

Download         Length: 240 bp

>AT222931 NZ_CP118156:c1779898-1779491 [Pseudomonas chlororaphis]
ATGCTTTACCCGATTGCAATTTCAATGGGCGATGACGAACACGCCTGGGGGGTGGAAGTCCCCGACATTCCTGGCTGTTT
CTCGGCCGGCGACGACCTCGACGACGCCATGGCCATGGCCCGCGAAGCCATCGAAGGGCACTTCGAGATTCTCGCTGAAG
ACGGTGCCCCCATCCCGCACGCCAACAAGGTCACCCTGCACGCCGCCAACCCCCGGTACGCAGGCTGCACCTGGGCGCTG
ATCGACATCGATGTCACCAAGTACCTGGGCAAGGCGCAGAAGCTCAACATCACCCTGCCCGGCTACTTGCTGAACCGCAT
CGACGAATACGTGCTGCATCACCCGGAAGCCAAGAGCCGCTCGGGTTTTCTCGCTTCGGCTGCACTGAAGGTATTGCAGC
AAGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References