Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 250521..251768 Replicon chromosome
Accession NZ_CP086295
Organism Burkholderia sp. B21-007

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LMA01_RS17565 Protein ID WP_228908215.1
Coordinates 250521..251102 (-) Length 194 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LMA01_RS17570 Protein ID WP_126225865.1
Coordinates 251211..251768 (-) Length 186 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LMA01_RS17545 (LMA01_17555) 246034..246939 - 906 WP_228908219.1 LysR family transcriptional regulator -
LMA01_RS17550 (LMA01_17560) 247117..248655 + 1539 WP_228908218.1 MFS transporter -
LMA01_RS17555 (LMA01_17565) 248703..249455 - 753 WP_228908217.1 DUF3658 domain-containing protein -
LMA01_RS17560 (LMA01_17570) 249751..250479 - 729 WP_228908216.1 class I SAM-dependent methyltransferase -
LMA01_RS17565 (LMA01_17575) 250521..251102 - 582 WP_228908215.1 HD domain-containing protein Toxin
LMA01_RS17570 (LMA01_17580) 251211..251768 - 558 WP_126225865.1 helix-turn-helix transcriptional regulator Antitoxin
LMA01_RS17575 (LMA01_17585) 251841..252488 - 648 WP_228908214.1 hypothetical protein -
LMA01_RS17580 (LMA01_17590) 252492..252740 + 249 WP_228908213.1 hypothetical protein -
LMA01_RS17585 (LMA01_17595) 252853..254256 + 1404 WP_228908212.1 DUF308 domain-containing protein -
LMA01_RS17590 (LMA01_17600) 254438..255169 + 732 WP_228908211.1 ribonuclease T2 -
LMA01_RS17595 (LMA01_17605) 255249..255884 - 636 WP_228908210.1 isochorismatase family cysteine hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-168)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-64)


Sequences

Toxin        


Download         Length: 194 a.a.        Molecular weight: 21357.92 Da        Isoelectric Point: 4.8417

>T222930 WP_228908215.1 NZ_CP086295:c251102-250521 [Burkholderia sp. B21-007]
MNLDTIHARLDFLRAAERLKDVLRSGHTSTGRPESTAEHSWRLCLMALVFADALPDVDTTKLLKLCVVHDLGEALHGDIP
AIEQAAHPDKSTRERDDLLTLTAGLDRALRDEIVALWDEYEAAESPEARAAKALDKLETILQHNQGSNPPDFDYAFNLGY
GRRYTDATPLFGAIRAIVDADTQRRIDARGDGA

Download         Length: 582 bp

>T222930 NZ_CP118156:1222221-1222499 [Pseudomonas chlororaphis]
GTGAGGGAATTGAAATGGACGAGCAAGGCACTGTCGGATCTGGCCCGACTGTTTGAGTTTCTTGCTCCGGTGAACCGTTC
GGTGGCAGCTCGAACTGTGCAATCGCTCACGCAGGCCCCGGATACCCTGCTGACCAATCCGCGTATCGGCGAACAGTTGG
AGGAGTTTCAGCCTCGCGATGTTCGGCGTTTATTGGTCGGGCCTTACGAGATGCGTTACGAGATCCAGGATGCGACGCTC
TACATCCTGCGGGTGTGGCATGTACGAGAAGACCGCTAG

Antitoxin


Download         Length: 186 a.a.        Molecular weight: 20256.23 Da        Isoelectric Point: 11.0874

>AT222930 WP_126225865.1 NZ_CP086295:c251768-251211 [Burkholderia sp. B21-007]
MTTSPLHTPPLGPQLKRWRTLRRVKQSHAAELFGVAQSTISRWEAGIQQMSPDERATAERLLAARLDSAGDHALARLIAS
STARMHLVCDLTHRLLACSPSRAAEFSRPLPALLGTSLWRYASPEIVRMEAALDPLGWHDRAGPPSVEFATGTNASRVVP
IRGSTCRWTRMTLSDGSAARLVETL

Download         Length: 558 bp

>AT222930 NZ_CP118156:1221961-1222224 [Pseudomonas chlororaphis]
ATGACCGCAACTAAAGTGCTGACCGCACATGTGCCGTTGGAGTTGGCCGACAAGGTCGACCAGATGGCCTCCCGGCTGGA
GCGCTCGCGCGGCTGGATCGTCAAGCAGGCTCTGGTGGCGTGGGTCGATCAGGAAGAGGAGCGCAGTCGCCTGACCCATG
AGGCTTTGGCCGATGTGGATGCTGGGCGGGTCATCGATCACCAGGCTGTCCAGGCATGGGCCGAGAGCCTGATGAATGAC
AAGCCTTTGCCGGTGCCCAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References