Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 1766387..1767072 Replicon chromosome
Accession NZ_CP086294
Organism Burkholderia sp. B21-007

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag LMA01_RS08255 Protein ID WP_228907579.1
Coordinates 1766650..1767072 (+) Length 141 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag LMA01_RS08250 Protein ID WP_228907578.1
Coordinates 1766387..1766653 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LMA01_RS08235 (LMA01_08240) 1761878..1764166 + 2289 WP_228907575.1 TonB-dependent siderophore receptor -
LMA01_RS08240 (LMA01_08245) 1764253..1765092 + 840 WP_228907576.1 formyltransferase family protein -
LMA01_RS08245 (LMA01_08250) 1765092..1766108 + 1017 WP_228907577.1 GNAT family N-acetyltransferase -
LMA01_RS08250 (LMA01_08255) 1766387..1766653 + 267 WP_228907578.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LMA01_RS08255 (LMA01_08260) 1766650..1767072 + 423 WP_228907579.1 PIN domain-containing protein Toxin
LMA01_RS08260 (LMA01_08265) 1767115..1768020 - 906 WP_228907580.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
LMA01_RS08265 (LMA01_08270) 1767989..1769080 - 1092 WP_267478976.1 type IV toxin-antitoxin system AbiEi family antitoxin -
LMA01_RS08270 (LMA01_08275) 1769415..1770578 + 1164 WP_228907581.1 M20 aminoacylase family protein -
LMA01_RS08275 (LMA01_08280) 1770609..1771934 - 1326 WP_228907582.1 cobyrinate a,c-diamide synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-130)

Antitoxin

SpoVT-AbrB domain

(7-55)


Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 14758.86 Da        Isoelectric Point: 7.8895

>T222929 WP_228907579.1 NZ_CP086294:1766650-1767072 [Burkholderia sp. B21-007]
VTTLYMLDTNICSFIMRERPSAVLSRLQSCVNAQHRIVVSAITYAEMRFGAVGRKASPKHAELVTAFVTRLDGVLSWDTA
AVDATAAIRVDLAARGTPIGANDASIAGHAIAAGAVLVTNNSREFSRVAGLSLEDWAASA

Download         Length: 423 bp

>T222929 NZ_CP118156:761764-762060 [Pseudomonas chlororaphis]
ATGCATATCATCACCGCCAAACGAATCTGGGAGGCCAAGAACCGCTGGCCACAATCGGCCAATGCTCTGGAAACCTGGTA
CAGAAAAGCCAAAAGCCTCAATCCGGCCGATTTTGCAGCCATCAAGGCGGTATTTCCGGCCACCGACAAAGTGGGGGCGT
TTCACGTCTTCGATATTGGTGGCAACAAGTTACGAATCATCGCCGTGGTGCGTTATGAAGTACGACGTCTCTATATCAGG
CACGTGCTGGACCATCACGAATACGACAAAGGCAGGTGGAAGGAGGAAACCAGATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10043.33 Da        Isoelectric Point: 4.5386

>AT222929 WP_228907578.1 NZ_CP086294:1766387-1766653 [Burkholderia sp. B21-007]
MRTVSIFKNARNQAIRIPKDMEFEGVTELEIRREGDTLLLRPVRPTWLSFASEPRADADFLVERPTVVELGRFDLPGADD
DAPTESNR

Download         Length: 267 bp

>AT222929 NZ_CP118156:762057-762458 [Pseudomonas chlororaphis]
ATGAACGTTCTGGTGAAGCAGGCGGCGGATCATTGGCATTTCGTGGCGCCTGTGTTGCGTAAACCCAAGACCGAAGCCGA
TTACGATGCATTGGTCGCCGCGCTGGATGAACTGCTGGATCTCATGGGAGAGGACGAGAACCATCCAGTGACTTCGCTGG
TGGACATCATCGGCGACTGGATCGAAGCCTACGACGAAGAACACCGACCGATGCCGATAGCCAGTGGTGTTGACGTCTTG
CGCTCCCTGATGCGCGAACATGGCCTGACCCAGAGCGATCTGCCAGGCGTGGGCGCGCAGTCGGTGGTTTCCGAAGTGCT
GAGCGGCAAGCGCCAGCTCAACCTGCGGCAGATCCGCTGGCTGGCCGAGCGCTTCGGTGTTTCGGCCGAGGTCTTTATCT
GA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References