Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 2592191..2592710 Replicon chromosome
Accession NZ_CP086292
Organism Burkholderia ambifaria strain B21-008

Toxin (Protein)


Gene name relE Uniprot ID B1Z1X1
Locus tag LL999_RS27635 Protein ID WP_012367044.1
Coordinates 2592429..2592710 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q0B637
Locus tag LL999_RS27630 Protein ID WP_011659781.1
Coordinates 2592191..2592439 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LL999_RS27620 (LL999_27625) 2589642..2590832 + 1191 WP_011659783.1 2-methylaconitate cis-trans isomerase PrpF -
LL999_RS27625 (LL999_27630) 2590996..2592048 + 1053 WP_175677684.1 CaiB/BaiF CoA-transferase family protein -
LL999_RS27630 (LL999_27635) 2592191..2592439 + 249 WP_011659781.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LL999_RS27635 (LL999_27640) 2592429..2592710 + 282 WP_012367044.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LL999_RS27640 (LL999_27645) 2592833..2593276 - 444 WP_006757720.1 PaaI family thioesterase -
LL999_RS27645 (LL999_27650) 2593536..2595170 + 1635 WP_229063078.1 methyl-accepting chemotaxis protein -
LL999_RS27650 (LL999_27655) 2595143..2596252 - 1110 WP_229063079.1 AGE family epimerase/isomerase -
LL999_RS27655 (LL999_27660) 2596364..2597062 + 699 WP_126226210.1 MgtC/SapB family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-81)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10983.88 Da        Isoelectric Point: 10.7091

>T222927 WP_012367044.1 NZ_CP086292:2592429-2592710 [Burkholderia ambifaria]
MTFELAFLEPALKEWKKLDRTIRDQFKSRLAERLENPRIASAKLHGHPDRYKIKLRSVGYRLVYEVRDTEVIVLVVAVGR
RDRDAVYLAAMKR

Download         Length: 282 bp

>T222927 NZ_CP118156:533971-534153 [Pseudomonas chlororaphis]
ATGCGCAGTCGGGAACTGATCAGGATGATCGAGGAGGACGGGTGGTATCTGATCGCGGTCAAAGGCAGTCATCACCAGTA
CAAGCATCTGCACAAGCCGGGGCGGGTCACTATCCCTCACCCGGATGCGGATCTGCCCAGGGGCACGATCCACAGCATCT
TGAAACAGGCGGGCCTGAAATGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8989.36 Da        Isoelectric Point: 5.6566

>AT222927 WP_011659781.1 NZ_CP086292:2592191-2592439 [Burkholderia ambifaria]
MPHTILANVTASVSELKRNPMGTVAAGEGFPVAILNHNEPAFYCIPAKTWEAMVERLEDIEDNALANTRAKDKVVKVKLN
DL

Download         Length: 249 bp

>AT222927 NZ_CP118156:534183-534584 [Pseudomonas chlororaphis]
ATGAAATTCCCGGTCGTGCTGCACAAGGATGCCGACTCCGGATATGGAGTGATCGTCCCCGATGTGCCGGGCTGTTTTTC
CGCCGGTCATACCGCAGCAGAAGCCTTCGAGAATGTGAAAGAGGCCCTGTCGCTGCATTACGAAGGCCTGGTCGCCGATG
GTGAGCCGCTGCCCCAGGTGCATGAGGTCGACGTGCATATCGACAATCCCGATTACGCCGGTGGCGTGTGGGGCATGATC
GAGTTCGACATCACGCCTTACTTCGGCAAGGCGGTGCGCTTCAACGCCACCCTGCCGGAGCAATTGCTGGAACGCATCGA
CCAGACGGTGAAGCGCGACCAGCGCTACCGCTCGCGTTCGGGCTTCCTTGCCGCAGCGGCATTGCGCGAGTTATCGGCGT
AG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B1Z1X1

Antitoxin

Source ID Structure
AlphaFold DB Q0B637

References