Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | phd-doc/HTH_IclR(antitoxin) |
| Location | 1456282..1458047 | Replicon | chromosome |
| Accession | NZ_CP086292 | ||
| Organism | Burkholderia ambifaria strain B21-008 | ||
Toxin (Protein)
| Gene name | doc | Uniprot ID | - |
| Locus tag | LL999_RS22435 | Protein ID | WP_229062291.1 |
| Coordinates | 1457136..1458047 (-) | Length | 304 a.a. |
Antitoxin (Protein)
| Gene name | phd | Uniprot ID | Q0B871 |
| Locus tag | LL999_RS22430 | Protein ID | WP_011659094.1 |
| Coordinates | 1456282..1457139 (-) | Length | 286 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LL999_RS22410 (LL999_22420) | 1451419..1452909 | - | 1491 | WP_229062290.1 | aldehyde dehydrogenase | - |
| LL999_RS22415 (LL999_22425) | 1453008..1453835 | - | 828 | WP_105833381.1 | aspartate dehydrogenase | - |
| LL999_RS22420 (LL999_22430) | 1453828..1455495 | - | 1668 | WP_105833380.1 | thiamine pyrophosphate-binding protein | - |
| LL999_RS22425 (LL999_22435) | 1455488..1456285 | - | 798 | WP_212081526.1 | SDR family oxidoreductase | - |
| LL999_RS22430 (LL999_22440) | 1456282..1457139 | - | 858 | WP_011659094.1 | IclR family transcriptional regulator | Antitoxin |
| LL999_RS22435 (LL999_22445) | 1457136..1458047 | - | 912 | WP_229062291.1 | alpha/beta fold hydrolase | Toxin |
| LL999_RS22440 (LL999_22450) | 1458067..1458594 | - | 528 | WP_012366322.1 | cupin domain-containing protein | - |
| LL999_RS22445 (LL999_22455) | 1458634..1459404 | - | 771 | WP_229062292.1 | SDR family oxidoreductase | - |
| LL999_RS22450 (LL999_22460) | 1459397..1460467 | - | 1071 | WP_011659097.1 | aromatic ring-hydroxylating dioxygenase subunit alpha | - |
| LL999_RS22455 (LL999_22465) | 1460522..1460833 | - | 312 | WP_011659098.1 | hypothetical protein | - |
| LL999_RS22460 (LL999_22470) | 1460926..1462005 | + | 1080 | WP_175674320.1 | RNA-guided endonuclease TnpB family protein | - |
| LL999_RS22465 (LL999_22475) | 1461992..1462309 | - | 318 | WP_105833396.1 | non-heme iron oxygenase ferredoxin subunit | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 304 a.a. Molecular weight: 31204.50 Da Isoelectric Point: 7.0644
>T222925 WP_229062291.1 NZ_CP086292:c1458047-1457136 [Burkholderia ambifaria]
MSVIDKRERDRTAAFAALLGQFPEQRCAAGAAGTIGYREAGAGEAGAQHAGHALPVVLLHGIGSGAASWVCQLDTLGASR
RVLAWDAPGYGVSTPVHGASPTAADYAASLNAWLEALGIERCVLVGHSLGAIIAGGLCRLMPARIAGLLLISPAGGYGRA
PAETRDTRRDARLAMLAELGPAGLAEQRSGNMLSGFASEDARAWVRWNMARIVPAGYAQATHLLANADLATDLAGFRGRT
AVAVGANDAITPPAACERIAAAAQVELQVIPQAGHAGYVEAPAVYSSLIDTFCRQCDTQRGMA
MSVIDKRERDRTAAFAALLGQFPEQRCAAGAAGTIGYREAGAGEAGAQHAGHALPVVLLHGIGSGAASWVCQLDTLGASR
RVLAWDAPGYGVSTPVHGASPTAADYAASLNAWLEALGIERCVLVGHSLGAIIAGGLCRLMPARIAGLLLISPAGGYGRA
PAETRDTRRDARLAMLAELGPAGLAEQRSGNMLSGFASEDARAWVRWNMARIVPAGYAQATHLLANADLATDLAGFRGRT
AVAVGANDAITPPAACERIAAAAQVELQVIPQAGHAGYVEAPAVYSSLIDTFCRQCDTQRGMA
Download Length: 912 bp
>T222925 NZ_CP118155:4784484-4784834 [Pseudomonas chlororaphis]
ATGGACGCACTTTTTATTGAGCTGCCCCCGTTCCAACGCCATCGACAGGACTACCTGGACGACGAGCTTTTTCGTAGCTT
GCAGCTTGAATTGCTGAAAGCCCCCGAAGCCGGAGATCTCATCGAGGGAGTCGGTGGCTTGCGCAAGATCCGCTTTGTCG
ATGAGCGACGGCACAAGGGCAAACGCGGCGGGATCCGGGTGATTTATTACTGGTGGTCCGGAGGCGCCCAGTTCTGGCTC
TTCACCCTTTACGCAAAGAACGAGCAGAACGACCTGACATCCCATCAGAAAAAACTGCTCAAGCAACTGCTGAACAGAGA
AGTCGAGGCGAGAACCCATCATGAAACGTGA
ATGGACGCACTTTTTATTGAGCTGCCCCCGTTCCAACGCCATCGACAGGACTACCTGGACGACGAGCTTTTTCGTAGCTT
GCAGCTTGAATTGCTGAAAGCCCCCGAAGCCGGAGATCTCATCGAGGGAGTCGGTGGCTTGCGCAAGATCCGCTTTGTCG
ATGAGCGACGGCACAAGGGCAAACGCGGCGGGATCCGGGTGATTTATTACTGGTGGTCCGGAGGCGCCCAGTTCTGGCTC
TTCACCCTTTACGCAAAGAACGAGCAGAACGACCTGACATCCCATCAGAAAAAACTGCTCAAGCAACTGCTGAACAGAGA
AGTCGAGGCGAGAACCCATCATGAAACGTGA
Antitoxin
Download Length: 286 a.a. Molecular weight: 31403.94 Da Isoelectric Point: 6.3573
>AT222925 WP_011659094.1 NZ_CP086292:c1457139-1456282 [Burkholderia ambifaria]
MSEPLQQPESDSTKADAGYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYK
LGIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQCQSPVFSAIRVNVGTRLPAHATTHGH
VLMGDLSLKELRALYPEGTLSRMTSATPETVDALYEMIREDALRGYGVSNSSFERGISVVTAPVRNDTQKIVACITVTVP
RPEIDEALIADGLFDKVQRAAAELSRRLNYRSDDEHTFLKALGLR
MSEPLQQPESDSTKADAGYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYK
LGIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQCQSPVFSAIRVNVGTRLPAHATTHGH
VLMGDLSLKELRALYPEGTLSRMTSATPETVDALYEMIREDALRGYGVSNSSFERGISVVTAPVRNDTQKIVACITVTVP
RPEIDEALIADGLFDKVQRAAAELSRRLNYRSDDEHTFLKALGLR
Download Length: 858 bp
>AT222925 NZ_CP118155:4784824-4785138 [Pseudomonas chlororaphis]
ATGAAACGTGACATCTTTTCCGAACTGGTCGAAGGTTTCGACACCCTGGCCAAAGAGCGCCAAGGCAAGCTCACGCTGCG
CACCCACAAGGTCAAGCTGAACGCACTGCTACCGATCACCGCTGAAGAAGTGCTGGCCGTGCGCGAACAGCTGAACCTGT
CCAGATCGGTATTTGCCATGTACCTGCGCACCAATACTCGGACCCTGGAGAACTGGGAGCAAGGACGGGCAAAACCCAAC
GCCCAGGCCACCACCCTGATCCGCCTGGTACAGCGTTTTCCCGATACGGTGGAGCGGCTGGCAGCCCTTGCCTGA
ATGAAACGTGACATCTTTTCCGAACTGGTCGAAGGTTTCGACACCCTGGCCAAAGAGCGCCAAGGCAAGCTCACGCTGCG
CACCCACAAGGTCAAGCTGAACGCACTGCTACCGATCACCGCTGAAGAAGTGCTGGCCGTGCGCGAACAGCTGAACCTGT
CCAGATCGGTATTTGCCATGTACCTGCGCACCAATACTCGGACCCTGGAGAACTGGGAGCAAGGACGGGCAAAACCCAAC
GCCCAGGCCACCACCCTGATCCGCCTGGTACAGCGTTTTCCCGATACGGTGGAGCGGCTGGCAGCCCTTGCCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|