Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 1217749..1218388 Replicon chromosome
Accession NZ_CP086292
Organism Burkholderia ambifaria strain B21-008

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LL999_RS21370 Protein ID WP_175678419.1
Coordinates 1217749..1218165 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LL999_RS21375 Protein ID WP_105831267.1
Coordinates 1218152..1218388 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LL999_RS21335 (LL999_21350) 1213332..1214495 + 1164 WP_229063860.1 MFS transporter -
LL999_RS21340 (LL999_21355) 1214519..1214767 - 249 WP_175699185.1 hypothetical protein -
LL999_RS21345 (LL999_21360) 1215042..1215570 - 529 Protein_1080 transferase hexapeptide repeat family protein -
LL999_RS21350 (LL999_21365) 1215574..1215840 - 267 Protein_1081 FAD-binding protein -
LL999_RS21355 (LL999_21370) 1215836..1215949 + 114 Protein_1082 4-hydroxy-2-oxovalerate aldolase -
LL999_RS21360 (LL999_21375) 1216245..1216508 - 264 WP_006751842.1 translation initiation factor IF-1 -
LL999_RS21365 (LL999_21380) 1216970..1217173 - 204 WP_006751843.1 cold-shock protein -
LL999_RS21370 (LL999_21385) 1217749..1218165 - 417 WP_175678419.1 type II toxin-antitoxin system VapC family toxin Toxin
LL999_RS21375 (LL999_21390) 1218152..1218388 - 237 WP_105831267.1 DNA-binding protein Antitoxin
LL999_RS21380 (LL999_21395) 1218637..1219839 - 1203 WP_229063861.1 glycosyltransferase family 87 protein -
LL999_RS21385 (LL999_21400) 1220066..1221292 + 1227 WP_175663754.1 acyltransferase -
LL999_RS21390 (LL999_21405) 1221305..1221601 - 297 WP_229064032.1 hypothetical protein -
LL999_RS21395 (LL999_21410) 1222017..1222886 - 870 WP_229063862.1 LysR substrate-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-130)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15240.41 Da        Isoelectric Point: 6.6443

>T222924 WP_175678419.1 NZ_CP086292:c1218165-1217749 [Burkholderia ambifaria]
VFLIDTNVISEIRKGKRTNRGVRAFFTQAEADASPLYLSVVTVAELRRGVDLIRHRGDHPQASALEAWMATILSGYASNI
LPVDIETAQMWGHLRVPDPAHALDHLIAATALINDLTVVTRNVDDFARTGVRLLNPFD

Download         Length: 417 bp

>T222924 NZ_CP118155:c2627566-2627273 [Pseudomonas chlororaphis]
ATGGAATACGAGATCCTGCAGACGACCGTCTTTGCCCAATGGCACACCAGACTACGGGACCTGCGCGCCAGGATAGCCAT
CGCTCGGCGTATCGAGCGGGCTTCGGCGGGCAACCTGGGCGATGTGAAAAACCTCGGCGGCGGTCTCTCGGAAATGCGCG
TGAATAGGGGCGCCGGCTACCGCATCTATTTCACGGTTCGCGGCAACACCCTCATCGTCCTGCTGCTGGGCGGCGACAAG
TCCACCCAGCCTGCCGATATCTGCCAGGCCCGTTCCCTGGCCAAGGAGTTCTGA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8691.74 Da        Isoelectric Point: 5.6786

>AT222924 WP_105831267.1 NZ_CP086292:c1218388-1218152 [Burkholderia ambifaria]
MANLLVRNVDDSIVQSLREQAAANGRSAEAEHRAILAEALGRPKRRTFAHVLMSMPDVGEDADFQRVQDSGEVRRVFD

Download         Length: 237 bp

>AT222924 NZ_CP118155:c2627271-2626981 [Pseudomonas chlororaphis]
ATGTCCGACACACTGGTTCCCTTCGACATCGCCACCCTGCTCGACAGCGACCAGGCGATCAGCGAATACCTGTCCCAGGT
CCTGGCCGATGGCGATACCGATGAACTGATCCGCGCCCTGGGCCATGTCGCCAGGGCCCGGGGCATGACGCAGATTGCCA
AGGCCACCGGCCAGGGCCGGGCCAGCCTCTACAAGGCCTTTGCCCCGGGCGCCAAGCCGCGCTTCGATACCGTGGTCAAG
GTCATGCGCGCGCTGGGCCTGCAGTTGTGCACCACAGTGCCCCGAGGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References