Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 1128066..1128733 Replicon chromosome
Accession NZ_CP086292
Organism Burkholderia ambifaria strain B21-008

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag LL999_RS21005 Protein ID WP_164714744.1
Coordinates 1128066..1128362 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag LL999_RS21010 Protein ID WP_229063814.1
Coordinates 1128365..1128733 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LL999_RS20990 (LL999_21005) 1123453..1124772 + 1320 WP_229063812.1 cytochrome c -
LL999_RS20995 (LL999_21010) 1124934..1126379 + 1446 WP_126225413.1 NAD-dependent succinate-semialdehyde dehydrogenase -
LL999_RS21005 (LL999_21020) 1128066..1128362 + 297 WP_164714744.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LL999_RS21010 (LL999_21025) 1128365..1128733 + 369 WP_229063814.1 putative addiction module antidote protein Antitoxin
LL999_RS21015 (LL999_21030) 1128965..1129138 + 174 Protein_1014 ISNCY family transposase -
LL999_RS21020 (LL999_21035) 1129301..1131013 - 1713 WP_082089648.1 YadA family autotransporter adhesin -
LL999_RS21025 (LL999_21040) 1131403..1131795 + 393 WP_229063980.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1126483..1142618 16135


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-95)

Antitoxin

Uncharacterized protein HI1420

(16-97)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 10848.54 Da        Isoelectric Point: 8.9833

>T222923 WP_164714744.1 NZ_CP086292:1128066-1128362 [Burkholderia ambifaria]
MFKVLTTPQFDEWLEGLRDPVGSAAINLRIERAKLGNLGEWRAVGDGVNEMKIDVGPGYRAYFVRRGKIIVVVLCGGDKS
TQKKDIKTAKQIAGELED

Download         Length: 297 bp

>T222923 NZ_CP118155:c2627271-2626981 [Pseudomonas chlororaphis]
ATGTCCGACACACTGGTTCCCTTCGACATCGCCACCCTGCTCGACAGCGACCAGGCGATCAGCGAATACCTGTCCCAGGT
CCTGGCCGATGGCGATACCGATGAACTGATCCGCGCCCTGGGCCATGTCGCCAGGGCCCGGGGCATGACGCAGATTGCCA
AGGCCACCGGCCAGGGCCGGGCCAGCCTCTACAAGGCCTTTGCCCCGGGCGCCAAGCCGCGCTTCGATACCGTGGTCAAG
GTCATGCGCGCGCTGGGCCTGCAGTTGTGCACCACAGTGCCCCGAGGCTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 12925.75 Da        Isoelectric Point: 8.5337

>AT222923 WP_229063814.1 NZ_CP086292:1128365-1128733 [Burkholderia ambifaria]
MKISELAEFDGSKYLKDEEAIRHYLAQAFEDGDPRLIQAALGNVAKARGMTALARESGVKREALYRALSDGGNAEFATIM
KVVGALGLHLTVAPVVQADEAAPVPAPTPTRARSRGRAGVHA

Download         Length: 369 bp

>AT222923 NZ_CP118155:c2627566-2627273 [Pseudomonas chlororaphis]
ATGGAATACGAGATCCTGCAGACGACCGTCTTTGCCCAATGGCACACCAGACTACGGGACCTGCGCGCCAGGATAGCCAT
CGCTCGGCGTATCGAGCGGGCTTCGGCGGGCAACCTGGGCGATGTGAAAAACCTCGGCGGCGGTCTCTCGGAAATGCGCG
TGAATAGGGGCGCCGGCTACCGCATCTATTTCACGGTTCGCGGCAACACCCTCATCGTCCTGCTGCTGGGCGGCGACAAG
TCCACCCAGCCTGCCGATATCTGCCAGGCCCGTTCCCTGGCCAAGGAGTTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References