Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 593866..594521 Replicon chromosome
Accession NZ_CP086292
Organism Burkholderia ambifaria strain B21-008

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LL999_RS18555 Protein ID WP_165753457.1
Coordinates 594102..594521 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LL999_RS18550 Protein ID WP_229063967.1
Coordinates 593866..594105 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LL999_RS18525 (LL999_18545) 589130..589525 - 396 WP_006759143.1 type II toxin-antitoxin system VapC family toxin -
LL999_RS18530 (LL999_18550) 589522..589761 - 240 WP_011659184.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
LL999_RS18535 (LL999_18555) 589861..590544 - 684 WP_229063536.1 Fe2+-dependent dioxygenase -
LL999_RS18540 (LL999_18560) 590541..591296 - 756 WP_229063537.1 tetratricopeptide repeat protein -
LL999_RS18545 (LL999_18565) 591300..593543 - 2244 WP_229063538.1 TonB-dependent siderophore receptor -
LL999_RS18550 (LL999_18570) 593866..594105 + 240 WP_229063967.1 Arc family DNA-binding protein Antitoxin
LL999_RS18555 (LL999_18575) 594102..594521 + 420 WP_165753457.1 type II toxin-antitoxin system VapC family toxin Toxin
LL999_RS18560 (LL999_18580) 594663..595958 - 1296 WP_011659178.1 aspartate carbamoyltransferase -
LL999_RS18565 (LL999_18585) 596194..596328 + 135 WP_011659177.1 entericidin A/B family lipoprotein -
LL999_RS18570 (LL999_18590) 596424..596996 - 573 WP_175726466.1 permease -
LL999_RS18575 (LL999_18595) 597122..598081 - 960 WP_229063539.1 DMT family transporter -
LL999_RS18580 (LL999_18600) 598460..599254 - 795 WP_229063540.1 AraC family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-122)

Antitoxin

Arc-like DNA binding domain

(7-43)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14957.18 Da        Isoelectric Point: 5.8818

>T222921 WP_165753457.1 NZ_CP086292:594102-594521 [Burkholderia ambifaria]
MILVDTNVISEPLRREPSAAVIEWLDAQNVETLFLAAISLAEMRFGVAALPEGRRRDWLHQSIEQRVVPLFRGRILPFDD
AASKAYASLRAKARATGNAMASADGFIAATAAANGLIVATRDVAPFEAAGLRVIDPWAG

Download         Length: 420 bp

>T222921 NZ_CP118155:c1783199-1783017 [Pseudomonas chlororaphis]
GTGAACAGTCGGTATTTGATCGGCCAAATCGTCGCAGACGGTTGGTATCTGGTCAGGGTCAGAGGCAGTCACCACCCTTT
CAGGCACCCCAGTAAACCGGGGCTGGTGACAGTTCCACATCCCAAAAAGGACCTGCTGAGAAAAACCGCCATCAGCATTC
TGAAACAGGCGCTGCTCATGTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8604.73 Da        Isoelectric Point: 6.4688

>AT222921 WP_229063967.1 NZ_CP086292:593866-594105 [Burkholderia ambifaria]
MPVITVRNLPDEVHRALRIRAAQHGRSTEAEVRAILEEAVRPGGRTKLGSLLAEIGREAGGVDFENPRESSPTAPMSFE

Download         Length: 240 bp

>AT222921 NZ_CP118155:c1782984-1782577 [Pseudomonas chlororaphis]
ATGCTTTACCCGATTGCAATTTCAATGGGCGATGACGAACACGCCTGGGGCGTGGAAGTCCCCGACATTCCTGGCTGTTT
CTCGGCCGGCGACGACCTCGACGACGCCATGGCCATGGCCCGCGAAGCCATCGAAGGGCACTTCGAGATTCTCGCCGAAG
ACGGTGCCGCCATCCCGCCCGCCAACAAGGTCACCCTGCACGCGGCCAACCCTCAGTACGCAGGCCGCACCTGGGCGCTG
ATCGACATCGATGTCACCAAGTACCTGGGCAAGGCGCAGAAGCTCAACATCACCCTGCCCGGCTACCTGCTGAACCGCAT
CGACGAATACGTGCTGCATCACCCGGAAGCAAAAAGCCGCTCGGGTTTTCTCGCTTCGGCTGCATTGAAGGTATTGCAGC
AAGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References