Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 347836..349083 Replicon chromosome
Accession NZ_CP086292
Organism Burkholderia ambifaria strain B21-008

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LL999_RS17440 Protein ID WP_229063425.1
Coordinates 347836..348417 (-) Length 194 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LL999_RS17445 Protein ID WP_229063426.1
Coordinates 348526..349083 (-) Length 186 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LL999_RS17420 (LL999_17440) 343337..344242 - 906 WP_175676400.1 LysR family transcriptional regulator -
LL999_RS17425 (LL999_17445) 344420..345958 + 1539 WP_229063422.1 MFS transporter -
LL999_RS17430 (LL999_17450) 346002..346754 - 753 WP_229063423.1 DUF3658 domain-containing protein -
LL999_RS17435 (LL999_17455) 347049..347777 - 729 WP_229063424.1 class I SAM-dependent methyltransferase -
LL999_RS17440 (LL999_17460) 347836..348417 - 582 WP_229063425.1 HD domain-containing protein Toxin
LL999_RS17445 (LL999_17465) 348526..349083 - 558 WP_229063426.1 helix-turn-helix transcriptional regulator Antitoxin
LL999_RS17450 (LL999_17470) 349155..349802 - 648 WP_229063427.1 hypothetical protein -
LL999_RS17455 (LL999_17475) 350165..351568 + 1404 WP_229063428.1 DUF308 domain-containing protein -
LL999_RS17460 (LL999_17480) 351750..352481 + 732 WP_175667271.1 ribonuclease T2 -
LL999_RS17465 (LL999_17485) 352550..353185 - 636 WP_175712895.1 isochorismatase family cysteine hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

5'-deoxynucleotidase YfbR/HDDC2

(8-189)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-64)


Sequences

Toxin        


Download         Length: 194 a.a.        Molecular weight: 21586.08 Da        Isoelectric Point: 4.6865

>T222920 WP_229063425.1 NZ_CP086292:c348417-347836 [Burkholderia ambifaria]
MNLDTIHARLDFLREAERLKDVLRSGHTSTGRRESTAEHSWRLCLMALVFADALPDVDTTKLLKLCVVHDLGEALHGDIP
AIEQAAHPDKSTHERDDLLTLTAGLDRALRDEIVALWDEYEAAESPEARAAKALDKLETILQHNQGSNPPDFDYAFNLAY
GRRYTDATPLFDAIRAIVDADTQRRIDARGDDA

Download         Length: 582 bp

>T222920 NZ_CP118155:769603-769899 [Pseudomonas chlororaphis]
ATGCATATCATCACCGCCAAACGAATCTGGGAGGCCAAGAGTCGCTGGCCGCAATCGGCCAATGCGCTGGAGACCTGGTA
CAGAAAAGTCAAAAGCCTCAATCCGGCTGATTTTGCAGCTATCAAGGCGGTGTTTCCGGCCACCGACAAAGTGGGGGCGT
TTCACGTCTTCGATATTGGCGGCAACAAGTTACGAATCATCGCCGTGGTGCGTTATGAAGTGCGACGTCTCTATATCAGG
CACGTGCTGGACCATCACGAATACGACAAGGGCAGGTGGAAGGAGGAAACCAGATGA

Antitoxin


Download         Length: 186 a.a.        Molecular weight: 20226.20 Da        Isoelectric Point: 11.0874

>AT222920 WP_229063426.1 NZ_CP086292:c349083-348526 [Burkholderia ambifaria]
MTTSPLHTPPLGPQLKRWRTLRRVKQSHAAELFGVAQSTISRWEAGIQQMSPDERATAERLLAARLDSAGDHALARLIAS
STARMHLVCDLTHRLLACSPSRAAEFSRPLPALLGTSLWRYASPEIVRMEAALDPLGWHDRAGPPSVEFATGTNASRVVP
IRGGTCRWTRMTLSDGSAARLVETL

Download         Length: 558 bp

>AT222920 NZ_CP118155:769896-770297 [Pseudomonas chlororaphis]
ATGAATGTTCTGGTGAGGCAGGCGGCGGAGCATTGGCATTTCGTCGCCCCTGTGTTGCGTAAACCCAAGACCGAAGCCGA
TTACGATGCATTGGTCGTGGCGCTGGATGAACTGCTGGATCTCATGGGAGAGGACGAGAACCATCCAGTGACTTCGCTGG
TGGACATCATCGGCGATTGGATCGAAGCCTACGACGAAGAGCATCGACCGATGCCGATAGCCAGTGGCGTTGATGTCTTG
CGCTCCCTGATGCGCGAACATGGCCTGACCCAGAGCGATCTGCCAGGCGTGGGTGCGCAGTCGGTGGTTTCGGAAGTGCT
GAGCGGCAAGCGCCAGCTCAACCTGCGGCAGATCCGCTGGCTGGCCGAGCGCTTCGGTGTTTCGGCCGAGGTATTTATCT
AA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References