Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 1695579..1696264 Replicon chromosome
Accession NZ_CP086291
Organism Burkholderia ambifaria strain B21-008

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag LL999_RS07860 Protein ID WP_175679899.1
Coordinates 1695842..1696264 (+) Length 141 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag LL999_RS07855 Protein ID WP_229062199.1
Coordinates 1695579..1695845 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LL999_RS07840 (LL999_07845) 1691087..1693360 + 2274 WP_175679903.1 TonB-dependent siderophore receptor -
LL999_RS07845 (LL999_07850) 1693447..1694286 + 840 WP_006755049.1 formyltransferase family protein -
LL999_RS07850 (LL999_07855) 1694286..1695302 + 1017 WP_175679901.1 GNAT family N-acetyltransferase -
LL999_RS07855 (LL999_07860) 1695579..1695845 + 267 WP_229062199.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LL999_RS07860 (LL999_07865) 1695842..1696264 + 423 WP_175679899.1 type II toxin-antitoxin system VapC family toxin Toxin
LL999_RS07865 (LL999_07870) 1696345..1696791 - 447 WP_229062200.1 MaoC family dehydratase -
LL999_RS07870 (LL999_07875) 1697056..1697961 - 906 WP_229062201.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
LL999_RS07875 (LL999_07880) 1697930..1699234 - 1305 WP_267479018.1 type IV toxin-antitoxin system AbiEi family antitoxin -
LL999_RS07880 (LL999_07885) 1699357..1700520 + 1164 WP_229062202.1 M20 aminoacylase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-130)

Antitoxin

SpoVT-AbrB domain

(7-54)


Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 14802.91 Da        Isoelectric Point: 7.8895

>T222919 WP_175679899.1 NZ_CP086291:1695842-1696264 [Burkholderia ambifaria]
VTTLYMLDTNICSFIMRERPSVVLSRLQSCVNAQHRIVVSAITYAEMRFGAVGRKASPKHAELVTAFVSRLDGVLSWDTA
AVDATTAIRVDLAARGTPIGANDASIAGHAIAAGAVLVTNNSREFSRVAGLSLEDWAASA

Download         Length: 423 bp

>T222919 NZ_CP118155:c545831-545403 [Pseudomonas chlororaphis]
ATGATAGTACTCGACACAAATGTGTTGTCAGAACTGATGCACCCTCAACCGGATACGGCGGTATTGCTGTGGATCGAAGC
GCAACCCGTCGAGGACCTCTACATCAGCGCCATGACCATGGCCGAGATTCTCCACGGTATCGCGCGTCTGCCCCACGGCA
AGCGCAAACAGACGCTGCATGCATCGGCGCTGGCCATGTTCGAGGAAGACTTCATCGACCGGATCGTGCCCTTCGGAACC
CAGGCGGCTCTTTACTACGCGCATCTGGTCTCGCATCGCGAAAGATCAGGCCAGCCGATCAACCTGGTGGACGCGCAGAT
TGCAGCGATATGCCGGGTCCATGACGCCGCGATTGCCACCCGCAACACCAAGGATTTCACCGACACTGGGCTGATCGTTA
TCAACCCCTGGCTACCGCTGGAAATCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10116.42 Da        Isoelectric Point: 4.6952

>AT222919 WP_229062199.1 NZ_CP086291:1695579-1695845 [Burkholderia ambifaria]
MRTVSIFKNARNQAIRIPKDMEFEGVTELEIRREGDTLLLRPVRPTWLSFATEPRADADFLVERPTVVELGRFDLRGADD
DAPTESNR

Download         Length: 267 bp

>AT222919 NZ_CP118155:c546073-545828 [Pseudomonas chlororaphis]
ATGGCCAGCCTTACGATCCGCAATCTGGACGACCACATCAAAGAACGCCTGCGCATCGAGGCCGCTCACAATGGTCATTC
CATGGAAGAAGAAGCCCGATTGATTTTGCGCCGCGCATTGAGCAGGACAGCTGACAGCCAAGGCCTGGGCAGCCGTATCA
GGGCACGCTTTGCCGAGACCGGCGGAGTAGAGTTGGAGCTGCCTGAACGTACCGAACCGGCACGCTTGGTGGACCTGGGC
GAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References