Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | IV | Classification (family/domain) | cptAB/Cpta(toxin) |
Location | 867020..867674 | Replicon | chromosome |
Accession | NZ_CP086287 | ||
Organism | Citrobacter freundii strain DY2010 |
Toxin (Protein)
Gene name | cptA | Uniprot ID | A0A0J1NHY7 |
Locus tag | LMH92_RS04250 | Protein ID | WP_003026936.1 |
Coordinates | 867267..867674 (+) | Length | 136 a.a. |
Antitoxin (Protein)
Gene name | cptB | Uniprot ID | A0A6H3AT26 |
Locus tag | LMH92_RS04245 | Protein ID | WP_003026938.1 |
Coordinates | 867020..867286 (+) | Length | 89 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
LMH92_RS04220 (862221) | 862221..863654 | - | 1434 | WP_044700805.1 | 6-phospho-beta-glucosidase BglA | - |
LMH92_RS04225 (863775) | 863775..864503 | - | 729 | WP_003838265.1 | MurR/RpiR family transcriptional regulator | - |
LMH92_RS04230 (864556) | 864556..864867 | + | 312 | WP_044700802.1 | N(4)-acetylcytidine aminohydrolase | - |
LMH92_RS04235 (865030) | 865030..865689 | + | 660 | WP_003838267.1 | hemolysin III family protein | - |
LMH92_RS04240 (865783) | 865783..866763 | - | 981 | WP_003026944.1 | tRNA-modifying protein YgfZ | - |
LMH92_RS04245 (867020) | 867020..867286 | + | 267 | WP_003026938.1 | FAD assembly factor SdhE | Antitoxin |
LMH92_RS04250 (867267) | 867267..867674 | + | 408 | WP_003026936.1 | protein YgfX | Toxin |
LMH92_RS04255 (867719) | 867719..868240 | - | 522 | WP_003026933.1 | flavodoxin FldB | - |
LMH92_RS04260 (868354) | 868354..869250 | + | 897 | WP_003026928.1 | site-specific tyrosine recombinase XerD | - |
LMH92_RS04265 (869274) | 869274..869987 | + | 714 | WP_003026923.1 | bifunctional protein-disulfide isomerase/oxidoreductase DsbC | - |
LMH92_RS04270 (869993) | 869993..871726 | + | 1734 | WP_044700800.1 | single-stranded-DNA-specific exonuclease RecJ | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 136 a.a. Molecular weight: 15953.89 Da Isoelectric Point: 11.4054
>T222904 WP_003026936.1 NZ_CP086287:867267-867674 [Citrobacter freundii]
VVQWQSDLRVSWRAQWLSLLIHGLVAVFILLMPWPLSYTPLWLVLLSLVVFDSVRSQRRINACQGEIRLLMDGRLRWQGQ
EWSIVSAPWMVKTGMMLRLRSDAGKRQHLWLAADSMDDAEWRDLRRLMLQKAKQK
VVQWQSDLRVSWRAQWLSLLIHGLVAVFILLMPWPLSYTPLWLVLLSLVVFDSVRSQRRINACQGEIRLLMDGRLRWQGQ
EWSIVSAPWMVKTGMMLRLRSDAGKRQHLWLAADSMDDAEWRDLRRLMLQKAKQK
Download Length: 408 bp
>T222904 NZ_CP118153:c1871058-1870876 [Pseudomonas chlororaphis]
GTGGACAGTCGGTATTTGATCGGCCAAATCGTCGCAGACGGTTGGTATCTGGTCAGGGTCAGAGGCAGTCACCATCATTT
CAGGCATCCCAGTAAACCGGGGCTGGTGACAGTGCCACATCCCAAAAAGGACCTGCTGAGAAAAACCGCCATCAGCATTC
TGAAACAGGCGCTGCTCATGTGA
GTGGACAGTCGGTATTTGATCGGCCAAATCGTCGCAGACGGTTGGTATCTGGTCAGGGTCAGAGGCAGTCACCATCATTT
CAGGCATCCCAGTAAACCGGGGCTGGTGACAGTGCCACATCCCAAAAAGGACCTGCTGAGAAAAACCGCCATCAGCATTC
TGAAACAGGCGCTGCTCATGTGA
Antitoxin
Download Length: 89 a.a. Molecular weight: 10558.09 Da Isoelectric Point: 5.1700
>AT222904 WP_003026938.1 NZ_CP086287:867020-867286 [Citrobacter freundii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFIRLLECDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFIRLLECDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI
Download Length: 267 bp
>AT222904 NZ_CP118153:c1870843-1870436 [Pseudomonas chlororaphis]
ATGCTTTACCCGATTGCAATTTCAATGGGCGATGACAAACACGCCTGGGGGGTGGAAGTCCCCGACATTCCTGGCTGTTT
CTCGGCCGGTGACGACCTCGACGACGCCATGGCCATGGCCCGCGAAGCCATCGAAGGGCACTTCGAGATTCTCGCCGAAG
ACGGTGCCCCCATCCCGCACGCCAACAAGGTCACCCTGCACGCAGCCAACCCTCAGTACGCAGGCTGCACCTGGGCGCTG
ATCGACATCGATATCACCAAGTACCTGGGCAAGGCGCAGAAGCTCAACATCACCCTGCCCGGCTACTTGCTGAACCGCAT
CGACGAATACGTGCTGCATCACCCGGAAGCCAAGAGCCGCTCGGGGTTTCTCGCTTCGGCTGCACTGAAGGTTTTGCAGC
AAGACTGA
ATGCTTTACCCGATTGCAATTTCAATGGGCGATGACAAACACGCCTGGGGGGTGGAAGTCCCCGACATTCCTGGCTGTTT
CTCGGCCGGTGACGACCTCGACGACGCCATGGCCATGGCCCGCGAAGCCATCGAAGGGCACTTCGAGATTCTCGCCGAAG
ACGGTGCCCCCATCCCGCACGCCAACAAGGTCACCCTGCACGCAGCCAACCCTCAGTACGCAGGCTGCACCTGGGCGCTG
ATCGACATCGATATCACCAAGTACCTGGGCAAGGCGCAGAAGCTCAACATCACCCTGCCCGGCTACTTGCTGAACCGCAT
CGACGAATACGTGCTGCATCACCCGGAAGCCAAGAGCCGCTCGGGGTTTCTCGCTTCGGCTGCACTGAAGGTTTTGCAGC
AAGACTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0J1NHY7 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A6H3AT26 |