Detailed information of TA system TA222899

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 4824502..4826183
• Replicon: chromosome
• Accession: NZ_CP086285
• Organism: Klebsiella pneumoniae strain Kp1

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: -
• Locus tag: LL004_RS23715
• Protein ID: WP_102013120.1
• Coordinates: 4824502..4825419 (-)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: LL004_RS23720
• Protein ID: WP_040168753.1
• Coordinates: 4825425..4826183 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LL004_RS23695	4819808..4821328	+	1521	WP_002885173.1	sugar ABC transporter ATP-binding protein	-
LL004_RS23700	4821325..4822323	+	999	WP_002885172.1	ribose ABC transporter permease	-
LL004_RS23705	4822354..4823295	+	942	WP_065808737.1	ABC transporter substrate-binding protein	-
LL004_RS23710	4823370..4824377	+	1008	WP_117045612.1	carbohydrate kinase family protein	-
LL004_RS23715	4824502..4825419	-	918	WP_102013120.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
LL004_RS23720	4825425..4826183	-	759	WP_040168753.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
LL004_RS23725	4826269..4826997	-	729	WP_002885152.1	response regulator transcription factor	-
LL004_RS23730	4827270..4829417	+	2148	WP_117045609.1	formate dehydrogenase subunit alpha	-
LL004_RS23735	4829647..4830333	+	687	WP_032413196.1	tetratricopeptide repeat protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34660.13 Da
• Isoelectric Point: 5.4707

>T222899 WP_102013120.1 NZ_CP086285:c4825419-4824502 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLSPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIVALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 918 bp

>T222899 NZ_CP118152:2678553-2678981 [Pseudomonas chlororaphis]
ATGATAGTACTCGACACAAATGTGTTGTCAGAACTGATGCGCCCTCAACCGGATACGGCGGTATTGCTGTGGATCGAAGC
GCAACCCGTCGAGGACCTCTACATCAGCGCTATGACCATGGCCGAGATTCTCCACGGTATCGCGCGCCTGCCCCACGGCA
AGCGCAAACAGACGCTGCATGCATCGGCGGTGGCCATGTTCGAGGAAGACTTCATCGACCGGATCGTGCCCTTCGGAACC
CAAGCAGCTCTTTACTACGCGCATCTGGTTTCGCATCGCGAAAGGTCAGGCCAGCCGATCAATCTGGTGGATGCGCAAAT
TGCAGCGATATGCCGGGTCCACGACGCCGCGATCGCCACTCGTAACACCAAGGATTTCACCGACACCGGGCTGATCGTTA
TCAACCCCTGGCTGCCGCTCGAGGTCTGA

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28578.95 Da
• Isoelectric Point: 10.0870

>AT222899 WP_040168753.1 NZ_CP086285:c4826183-4825425 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNTQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

>AT222899 NZ_CP118152:2678311-2678556 [Pseudomonas chlororaphis]
ATGGCCAGCCTTACGATCCGTAATCTGGACGACCACATCAAAGAACGCCTGCGCATCGAGGCCGCTCACAATGGTCATTC
CATGGAAGAAGAAGCCCGATTGATTTTGCGCCGCGCATTGAGCAGGACAGCTGACAGCCAAGGCCTGGGCAGCCGTATCA
GGGCACGCTTTGCCGAGACCGGCGGAGTAGAGCTGGAGCTGCCTGAACGTACCGAACCGGCACGCTTGGTGGACCTGGGC
GAATGA