Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3643708..3644365 Replicon chromosome
Accession NC_009648
Organism Klebsiella pneumoniae subsp. pneumoniae MGH 78578

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag KPN_RS17820 Protein ID WP_002916310.1
Coordinates 3643708..3644118 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag KPN_RS17825 Protein ID WP_002916312.1
Coordinates 3644099..3644365 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KPN_RS17800 (KPN_03320) 3639708..3641441 - 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -
KPN_RS17805 (KPN_03321) 3641447..3642160 - 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
KPN_RS17810 (KPN_03322) 3642183..3643079 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
KPN_RS17815 (KPN_03323) 3643180..3643701 + 522 WP_004144730.1 flavodoxin FldB -
KPN_RS17820 (KPN_03324) 3643708..3644118 - 411 WP_002916310.1 protein YgfX Toxin
KPN_RS17825 (KPN_03325) 3644099..3644365 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
KPN_RS17830 (KPN_03326) 3644611..3645594 + 984 WP_023286864.1 tRNA-modifying protein YgfZ -
KPN_RS17835 (KPN_03327) 3645693..3646352 - 660 WP_002916317.1 hemolysin III family protein -
KPN_RS17840 (KPN_03328) 3646516..3646827 - 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
KPN_RS17845 (KPN_03329) 3646877..3647605 + 729 WP_015958951.1 MurR/RpiR family transcriptional regulator -
KPN_RS17850 (KPN_03330) 3647724..3649157 + 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T22289 WP_002916310.1 NC_009648:c3644118-3643708 [Klebsiella pneumoniae subsp. pneumoniae MGH 78578]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T22289 NC_009648:c3644118-3643708 [Klebsiella pneumoniae subsp. pneumoniae MGH 78578]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT22289 WP_002916312.1 NC_009648:c3644365-3644099 [Klebsiella pneumoniae subsp. pneumoniae MGH 78578]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT22289 NC_009648:c3644365-3644099 [Klebsiella pneumoniae subsp. pneumoniae MGH 78578]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References