Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 791853..792510 Replicon chromosome
Accession NZ_CP086285
Organism Klebsiella pneumoniae strain Kp1

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag LL004_RS03930 Protein ID WP_002916310.1
Coordinates 792100..792510 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag LL004_RS03925 Protein ID WP_002916312.1
Coordinates 791853..792119 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LL004_RS03900 787009..788442 - 1434 WP_065801036.1 6-phospho-beta-glucosidase -
LL004_RS03905 788561..789289 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
LL004_RS03910 789339..789650 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
LL004_RS03915 789814..790473 + 660 WP_002916317.1 hemolysin III family protein -
LL004_RS03920 790624..791607 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
LL004_RS03925 791853..792119 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
LL004_RS03930 792100..792510 + 411 WP_002916310.1 protein YgfX Toxin
LL004_RS03935 792517..793038 - 522 WP_002916308.1 flavodoxin FldB -
LL004_RS03940 793139..794035 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
LL004_RS03945 794058..794771 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LL004_RS03950 794777..796510 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T222885 WP_002916310.1 NZ_CP086285:792100-792510 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T222885 NZ_CP118150:c2604145-2603855 [Pseudomonas chlororaphis]
ATGTCCGACACACTGGTTCCCTTCGACATCGCCGCCCTGCTCGACAGTGACCAGGCGATCAGCGAATACCTGTCCCAGGT
CCTGGCCGATGGCGATACCGATGAACTGATCCGCGCCCTGGGCCACGTCGCCAGGGCCCGGGGCATGACGCAGATTGCCA
AGGCCACCGGCCAGGGCCGGGCCAGCCTCTACAAGGCCTTTGCCCCGGGCGCCAAGCCGCGCTTCGATACCGTGGTCAAG
GTCATGCGCGCGCTGGGCCTGCAGCTGTGCACCACAGTGCCCCGTGGCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT222885 WP_002916312.1 NZ_CP086285:791853-792119 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT222885 NZ_CP118150:c2604440-2604147 [Pseudomonas chlororaphis]
ATGGATTACGAGATCCAGCAGACGACCGTCTTTGCCCAATGGCACACCAGACTACGGGACCTGCGCGCCAGGATAGCCAT
CGCTCGGCGTATCGAGCGGGCTTCGGCGGGCAACCTGGGCGATGTGAAAAACCTCGGCGGCGGTCTCTCGCAAATGCGCG
TGAATATGGGCGCCGGCTACCGCATCTATTTCACGGTTCGCGGCAATACCCTCATCGTCCTGCTGCTGGGCGGCGACAAA
TCCACCCAGCCAGCCGACATCTGCCAGGCTCGTTCCCTGGCCAAGGAGTTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References